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1.
Osteoporos Int ; 34(2): 269-290, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36370218

RESUMO

Transient osteoporosis (TO) or bone marrow edema syndrome (BMES) is a self-limited clinical condition, which affects middle-aged men and women. It can be treated with miscellaneous conservative and surgical measures, which are analyzed in this systematic review. INTRODUCTION: BMES/TO is a transient clinical entity, which can be treated with various therapeutic modalities. The aim of our study was to assess the efficacy of different therapeutic options for the alleviation of pain and reduction of bone marrow edema (BME) in patients with BMES/TO, as well as to propose a therapeutic algorithm. METHODS: PubMed, Scopus, Cochrane, and Google Scholar were searched. Eligibility and extraction of studies were conducted by two authors. Methodological quality assessment was carried out with the modified Delphi technique, Methodological Index for Non-Randomized Studies (MINORS) criteria, and Cochrane Collaboration's risk of bias tool. Outcomes that were compared were time of pain resolution, VAS pain scores, and BME regression on magnetic resonance imaging (MRI). RESULTS: A total of 36 articles (880 patients) were included. Bisphosphonates had higher efficiency in less than 1-month outcomes on pain resolution compared with core decompression (CD), while iloprost was more efficient at 1-3 months compared with bisphosphonates and CD. At 3-6 months, all three of the aforementioned showed equal results on pain resolution, and at a period of 6-12 months, CD and extracorporeal shockwave therapy (ESWT) showed excellent results followed by bisphosphonates and the conservative group (CG) consisting of non-steroidal anti-inflammatory drugs (NSAIDs) and/or analgesics and/or restricted weight bearing. On MRI at 1-3 months, bisphosphonates, iloprost, and CD had relatively the same outcomes on BME resolution, with the least promising being the CG. At 3-6 months, CD seemed to have achieved the best results on the resolution of BME, followed by ESWT, CG, and bisphosphonates group. At 6-12 months, ESWT had the best outcomes compared with the conservative, bisphosphonates, and iloprost groups. CONCLUSION: BMES/TO has been treated with many non-standardized measures due to the low number of highly reliable studies. Current literature shows promising results with regard to the reduction of the clinical course of BMES/TO, but further large multicenter randomized controlled trials, as well as standardized radiological and clinical scores, are warranted to acquire evidence-based recommendations on the therapeutic algorithm.


Assuntos
Doenças da Medula Óssea , Osteoporose , Masculino , Pessoa de Meia-Idade , Humanos , Feminino , Iloprosta/uso terapêutico , Medula Óssea , Doenças da Medula Óssea/terapia , Dor/tratamento farmacológico , Difosfonatos/uso terapêutico , Edema/terapia , Edema/tratamento farmacológico , Síndrome , Osteoporose/complicações , Osteoporose/tratamento farmacológico , Estudos Multicêntricos como Assunto
2.
BMC Musculoskelet Disord ; 24(1): 787, 2023 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-37794410

RESUMO

INTRODUCTION: Fragility fractures around the proximal end of the femur have increased in recent years due to an aging population, adding to the pressure on national health care systems and to hospital expenses. Peri-trochanteric fractures have historically been treated successfully with anatomic intramedullary nails, giving stable fixation in order to allow early for mobilisation of these frail patients. Some of these nails allow a second (anti-rotational) screw through the nail into the femoral head. We assessed the use of this additional screw in terms of quality of reduction, post-operative mobilization and complications. MATERIALS & METHODS: All patients who were treated in the same hospital for peri-trochanteric fracture between January 2017 and December 2019 were included in the study. The patients were randomly assigned into group A, where the treatment included intramedullary nailing using one femoral hip screw, and group B, where the treatment additionally included a second anti-rotational screw. The patients were followed up clinically and radiologically, for at least 3 months post-operatively. Demographic and operative data were collected alongside radiographic and clinical data. RESULTS: A total of 118 patients with an average age of 82.7 years were included in the study after exclusion criteria was applied. There were no statistically significant differences between the two groups regarding the ASA grade, Nottingham Hip fracture score, Koval score, Mental score, operation time, transfusion requirements, and operative radiation dose and time (p > 0.05). In group A, more complications were observed (p < 0.05). The radiographic measurements were statistically significantly different. CART analysis revealed that the use of a single screw in the femoral head for the subgroup of the unstable peri-trochanteric fractures (Jensen Type 4-5 - AO31A2.2 and above), has a tendency toward developing more post-operative complications, though this was not statistically significant. CONCLUSION: The use of an additional anti-rotational screw for unstable peri-trochanteric fractures (Jensen Type 4-5 and AO 31A2.2 and above) could prevent complications such as varus collapse and cut-out.


Assuntos
Fixação Intramedular de Fraturas , Fraturas do Quadril , Humanos , Idoso , Idoso de 80 Anos ou mais , Pinos Ortopédicos , Parafusos Ósseos , Fixação Intramedular de Fraturas/efeitos adversos , Fraturas do Quadril/diagnóstico por imagem , Fraturas do Quadril/cirurgia , Fraturas do Quadril/etiologia , Fixação Interna de Fraturas/efeitos adversos , Resultado do Tratamento
3.
Knee Surg Sports Traumatol Arthrosc ; 29(9): 3037-3048, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-33128588

RESUMO

PURPOSE: The purpose of this study was to systematically review case reports and case series about meniscal ossicle, to summarize existing evidence. Specifically, to identify the etiology, demographic characteristics, localization, clinical features, diagnostic procedures and treatment options of this rare entity. Although, case reports/ series are of low level of evidence, a systematic review of such studies can provide and help us to gain a better understanding and awareness of meniscal ossicle. METHODS: Two authors searched three online databases (MEDLINE, SCOPUS and GOOGLE SCHOLAR) from inception until March 2020 for the literature on meniscal ossicle. Inclusion criteria included case series, case reports and case-based reviews, available in full-text version, in English and that concern humans. Reports published in languages other than English were excluded, as well as articles with no electronic full text availability. Case reports using the term "meniscal ossicle" to describe an acute avulsion fracture of the tibial root of the meniscus, were also excluded. RESULTS: Of 453 initial studies, 38 studies satisfied inclusion criteria. In total 169 patients were included of whom 107 (63%) were males and 62 (37%) were females. Mean age was 44 years (range 12-87). According to Magnetic resonance imaging findings, in 144 knees (86%) the ossicle was localized at the posterior root or horn of the medial meniscus. 60% of the patients had a history of trauma. The predominant symptom in 87% of patients was knee pain. In all patients was detected an intra-articular density structure in computed radiography. 76% had associated meniscal tear, 61% had intraarticular cartilage loss, 34% meniscal extrusion and 28% anterior cruciate ligament injury. Treatment modalities included conservative regimen in 40 patients, while 59 patients underwent surgical excision. CONCLUSION: The most possible etiology of meniscal ossicle is posttraumatic heterotopic ossification and small occult bony avulsion fracture. It is commonly observed in individuals complaining about knee pain with history of antecedent trauma. The presence of a meniscal ossicle should alert the physician to the high likelihood of the patient having an associated meniscal tear, articular cartilage loss, ACL injury or meniscal extrusion. Along with the meniscal ossicle, the associated meniscal tear should be treated as well.


Assuntos
Lesões do Ligamento Cruzado Anterior , Traumatismos do Joelho , Lesões do Menisco Tibial , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Meniscos Tibiais , Pessoa de Meia-Idade , Osteogênese , Estudos Retrospectivos , Lesões do Menisco Tibial/diagnóstico por imagem , Lesões do Menisco Tibial/cirurgia , Adulto Jovem
4.
Med Sci Monit ; 25: 2151-2158, 2019 Mar 23.
Artigo em Inglês | MEDLINE | ID: mdl-30903656

RESUMO

BACKGROUND Osteoporosis affects millions of postmenopausal women worldwide. Invariant natural killer T cells (iNKT) are important cells for bone homeostasis. The sim of this study was to investigate the contribution of invariant natural killer T cells (iNKT) in the increased receptor activator of the nuclear factor-kappaB ligand (RANKL) pool and bone resorption, a characteristic of patients with osteoporosis. MATERIAL AND METHODS Whole blood was collected from 79 female patients. The dual energy x-absorptiometry scan was performed in all patients, and the T-score was calculated in order to classify our patients according to the World Human Organization (WHO) criteria for diagnosis and classification of osteoporosis. Eleven patients had a T-score -2.5 and were included in the osteoporosis group. We performed alpha-galactosylceramide activation of iNKT cells in vitro. Surface RANKL expression was detected by multicolor flow cytometry in naive and activated lymphocytes. Beta-Crosslaps (ß-CTx) levels were measured in whole blood plasma by ELISA (enzyme-linked immunosorbent assay). RESULTS Although iNKT cells were not clonally expanded in patients with osteoporosis, iNKT cells from osteoporotic patients overexpressed RANKL compared to ND and osteopenic patients. This is a distinctive feature of iNKT cells and is not seen in conventional T-lymphocytes. RANKL expression in iNKT cells was not related to ß-CTx levels in the blood. Finally, iNKT cell activation by the prototypal glycolipid ligand alpha-galactosylceramide increased by 8 times their RANKL expression. CONCLUSIONS In patients with osteoporosis, iNKT cells specifically overexpress RANKL, a cytokine that regulates osteoclast activity. It seems that iNKT cells have a long-standing effect of on the bone physiology, which plays an important role in the bone loss of patients with osteoporosis.


Assuntos
Células T Matadoras Naturais/metabolismo , Osteoporose/imunologia , Ligante RANK/metabolismo , Adulto , Idoso , Idoso de 80 Anos ou mais , Citocinas/metabolismo , Feminino , Citometria de Fluxo , Glicolipídeos/metabolismo , Humanos , Ativação Linfocitária , Pessoa de Meia-Idade , NF-kappa B/metabolismo , Ligante RANK/genética
5.
Arch Orthop Trauma Surg ; 139(6): 859-868, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30903342

RESUMO

BACKGROUND: Tranexamic acid (TXA) is widely used in the orthopedic field and particularly in total knee arthroplasty (TKA). Its efficacy and safety in reducing the blood loss in TKA have been well-documented in the current literature. Little data regarding TKA without tourniquet and TXA exist. Our aim is to compare three different dosages of intravenous (IV) TXA in TKA without tourniquet. MATERIALS AND METHODS: A total of 180 patients undergoing TKA for knee osteoarthritis were stratified in three equal groups. All surgeries were performed under spinal anesthesia, without tourniquet. Group A (60 patients) received 15 mg/kg of IV TXA given on induction, Group B (60 patients) received an additional dose of IV TXA (15 mg/kg) 3 h after incision and Group C (60 patients) received an additional (third) dose 3 h later (15 mg/kg). The measured outcomes were the change in hemoglobin (Hb) from pre-operatively to post-operatively, the amount of blood transfusion given (units), the functional and quality of life (QoL) and pain assessment based on their corresponding scoring system. RESULTS: Calculated blood loss, Hb decrease and transfusion rate were significantly lower in Group C (p value < 0.05). Additionally, patients that had been included in the three-dosage group benefited much more in terms of faster rehabilitation, better QoL, decreased post-operative pain, with no increase in complications. CONCLUSION: According to our results, three doses of IV TXA have effectively and safely reduced blood loss and the need of allogeneic blood transfusion in patients undergoing TKA without tourniquet, with additional patients-related benefits. LEVEL OF EVIDENCE: II.


Assuntos
Antifibrinolíticos/administração & dosagem , Artroplastia do Joelho , Ácido Tranexâmico/administração & dosagem , Antifibrinolíticos/uso terapêutico , Artroplastia do Joelho/efeitos adversos , Artroplastia do Joelho/métodos , Artroplastia do Joelho/estatística & dados numéricos , Transfusão de Sangue/estatística & dados numéricos , Hemoglobinas/análise , Humanos , Osteoartrite do Joelho/cirurgia , Dor Pós-Operatória/epidemiologia , Qualidade de Vida , Ácido Tranexâmico/uso terapêutico
6.
Foot Ankle Surg ; 25(1): 8-12, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-29409266

RESUMO

BACKGROUND: The purpose of this study was the translation, cross-cultural adaptation and validation of the Achilles Tendon Total Rupture Score (ATRS) in Greek population. METHODS: The translation and cross-cultural adaptation of the original version of ATRS in Greek language was performed according to the methodology described by Beaton et al. Validation and test-retest reliability were evaluated in forty-six patients, treated surgically for acute Achilles tendon rupture. Validity was evaluated by correlation of total and all subscale scores of Greek version of Manchester Foot Pain and Disability Index (MFPDI). Test-retest reliability evaluated with interclass correlation coefficient and Crombach's α coefficient was used for internal consistency. RESULTS: The internal consistency (α=0.96) and test-retest reliability (ICC=0.97) were excellent. There were no ceiling and floor effects during test-retest assessment. The Greek version of ATRS showed strong correlation with all subscales and overall score of MFPDI (pain subscale: R=-0.954, p<0.01, function subscale: R=-0.811, p<0.01, appearance subscale: R=-0.763, p<0.01, overall: R=-0.914, p<0.01). CONCLUSIONS: Greek version of ATRS was successfully adapted in Greek population and it appears to be a valid and reliable instrument to evaluate outcomes in Greek speaking patients after Achilles tendon rupture. LEVEL OF EVIDENCE: Level III.


Assuntos
Tendão do Calcâneo/lesões , Adaptação Psicológica , Comparação Transcultural , Traumatismos dos Tendões/diagnóstico , Adulto , Feminino , Grécia , Humanos , Masculino , Reprodutibilidade dos Testes , Ruptura , Inquéritos e Questionários , Traduções , Índices de Gravidade do Trauma , Adulto Jovem
7.
Eur J Orthop Surg Traumatol ; 29(4): 869-875, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30617921

RESUMO

INTRODUCTION: It is still unknown whether the creation of blood-free surfaces by the use of tourniquet during total knee arthroplasty (TKA) has an influence on cement penetration and on implant fixation. The aim of this study is to evaluate the cement mantle under tibial component and the occurrence of progressive radiolucent lines (RLLs) according to the use of tourniquet in primary TKA. MATERIALS AND METHODS: Fifty patients undergone TKA without the use of tourniquet (group 1) were well matched regarding baseline characteristics with 50 TKAs with the use of tourniquet (group 2). Patients were followed up prospectively. Cement mantle thickness was measured using immediate postoperative X-rays, and the occurrence of progressive radiolucency was finally evaluated in 3-year follow-up. New Knee Society Score (KSS) was used to compare clinical outcome between groups. RESULTS: Mean cement mantle thickness was 9.27 ± 1.86 mm in group 1 versus 10.49 ± 2.31 mm in group 2 (p = 0.005). Mean cumulated width of RLLs in anterioposterior (AP) view was 7.74 ± 6.68 mm in group 1 versus 3.48 ± 4.69 mm in group 2 (p < 0.001). The percentage of RLLs in AP view was related to the cumulated cement mantle thickness in the same view (r = - 0.218, p < 0.05). There was no significant difference between groups at the final follow-up in terms of ROM and new KSS. CONCLUSION: Our results suggest that the use of tourniquet increased the cement mantle thickness under tibial implant and had an influence on the occurrence of RLLs in cement-bone interface, which is related to implant survivorship, with this implant design.


Assuntos
Artroplastia do Joelho , Cimentos Ósseos , Interface Osso-Implante , Articulação do Joelho/diagnóstico por imagem , Prótese do Joelho , Torniquetes , Idoso , Idoso de 80 Anos ou mais , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Avaliação de Resultados da Assistência ao Paciente , Satisfação do Paciente , Radiografia , Amplitude de Movimento Articular , Estudos Retrospectivos
8.
Eur J Orthop Surg Traumatol ; 29(7): 1575-1578, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31250224

RESUMO

The original version of this article unfortunately contained a mistake. Table 1 footnotes were missing.

9.
Eur J Orthop Surg Traumatol ; 29(7): 1565-1574, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31177349

RESUMO

In this article, two cases of ulnar nerve neuropathy in Guyon's canal caused by a ganglion cyst are reported. A review of the literature found 73 cases reported in 35 articles of ulnar neuropathy at the wrist secondary to a ganglion cyst. We investigated the pathogenesis of ganglion cysts, which are separated as extraneural and intraneural. At this anatomical area, there are a variety of clinical factors that can also lead to ulnar nerve compression such us trauma, fracture of the hamate's hook, arterial thrombosis, tumors and other anatomical variations. The symptoms may include weakness, paresthesia, numbness and atrophy of hypothenar muscles. Except the careful clinical assessment, magnetic resonance imaging, ultrasound and electrophysiological control are useful tools regarding our differential diagnosis. The treatment of this clinical condition is surgical. We consider that instant surgical decompression is of the essence and enables postoperatively total recovery. LEVEL OF EVIDENCE: Level III.


Assuntos
Cistos Glanglionares/complicações , Cistos Glanglionares/cirurgia , Síndromes de Compressão do Nervo Ulnar/etiologia , Síndromes de Compressão do Nervo Ulnar/cirurgia , Feminino , Cistos Glanglionares/diagnóstico , Humanos , Masculino , Pessoa de Meia-Idade , Punho
11.
Med Sci Monit ; 24: 7665-7672, 2018 Oct 27.
Artigo em Inglês | MEDLINE | ID: mdl-30367027

RESUMO

BACKGROUND The Nottingham Hip Fracture Score (NHFS) is validated as a predictive mortality tool in patients with hip fracture. However, it has not been modified or validated widely other than in the UK NHS health systems. MATERIAL AND METHODS We assessed the predictive capability of the NHFS for 30-day mortality after surgery for hip fracture in the Greek population and then compared the original model to a modified one. We applied the NHFS to the Greek population and created a modified model of the NHFS by including the New Mobility Score (NMS) (Parker and Palmer, 1993) to the evaluated parameters and excluding the parameter of institution. We ran a prospective study over a period of 3 years in our institution, collecting full data from 349 patients. All data were analyzed using SPSS, version 20. RESULTS From all 349 patients, with a mean age of 80.82 years, only 85 (24.4%) were men. All patients were followed up for at least 30 days and the NHFS and modified NHFS prediction were compared with the mortality rate of patients. The area under the ROC curve for both models suggested acceptable accuracy (original NHFS 0.83, modified NHFS 0.84). Calibration was acceptable for both models (Hosmer-Lemeshow p=0.31 and 0.11, respectively). CONCLUSIONS Both the original and the modified NHFS were significant predictors of 30-day mortality. A higher-power study might be able to show superiority of the modified one for the Greek population in the future.


Assuntos
Fraturas do Quadril/mortalidade , Medição de Risco/métodos , Idoso , Idoso de 80 Anos ou mais , Técnicas de Apoio para a Decisão , Feminino , Grécia , Fraturas do Quadril/cirurgia , Mortalidade Hospitalar , Humanos , Masculino , Ossos Pélvicos/lesões , Ossos Pélvicos/cirurgia , Estudos Prospectivos , Curva ROC , Reprodutibilidade dos Testes , Fatores de Risco , Sensibilidade e Especificidade
12.
Folia Med (Plovdiv) ; 60(1): 175-179, 2018 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-29668444

RESUMO

Radio-opaque formations behind the spinous processes of the cervical spine are really rare. They were described in 1929 for the first time. Sesamoid ossicles are found close to a bone or a joint and are usually small. Some sesamoids form part of normal human anatomy, while others are normal anatomical variants. We report a case of a 73-year-old Caucasian male who visited the outpatient clinic complaining about chronic cervical pain. An oblong sesamoid accidentally discovered during routine anteroposterior (AP) and lateral x-ray, within the nuchal ligament (NL) at the C3-C6 spinous processes level. A cervical MRI scan was performed and the result showed 'fabella nuchae'. This type of sesamoids are rarely symptomatic, but it should be differentially diagnosed anyway. We review its morphology, the mechanical factors of the region acting throughout life and last, but not least, the differential diagnosis.


Assuntos
Vértebras Cervicais , Ligamentos , Ossificação Heterotópica , Ossos Sesamoides , Idoso , Vértebras Cervicais/diagnóstico por imagem , Vértebras Cervicais/patologia , Dor Crônica/diagnóstico por imagem , Dor Crônica/etiologia , Humanos , Ligamentos/diagnóstico por imagem , Ligamentos/patologia , Imageamento por Ressonância Magnética , Masculino , Cervicalgia/diagnóstico por imagem , Cervicalgia/etiologia , Ossificação Heterotópica/complicações , Ossificação Heterotópica/diagnóstico por imagem , Ossificação Heterotópica/patologia , Radiografia , Ossos Sesamoides/diagnóstico por imagem , Ossos Sesamoides/patologia
13.
J Arthroplasty ; 31(11): 2465-2470, 2016 11.
Artigo em Inglês | MEDLINE | ID: mdl-27267228

RESUMO

BACKGROUND: Use of tranexamic acid (TXA) is effective and safe in reducing the blood loss in total knee arthroplasty (TKR) performed using a tourniquet, but, data in TKR performed without tourniquet are limited, and there is no study comparing the topical (T) with intravenous (IV) TXA administration. Our aim was to compare the topical (T) with intravenous (IV) TXA administration in TKR performed without tourniquet. MATERIAL AND METHODS: A total of 120 patients undergoing unilateral TKR for knee osteoarthritis were included in a prospective randomized study. Operations were performed under spinal anesthesia, no tourniquet was used, and the postoperative regime was the same for all patients. Patients were divided into 3 groups; in group C (control), 40 patients received no TXA, in group IV, 40 patients received 1 g of TXA intravenously, and in group L, 1 g of TXA was applied locally to 40 patients. The primary outcome measures included the calculated blood loss, the transfusion rate, and quantity of allogeneic blood units, whereas secondary outcome measures were complications. RESULTS: There was no statistically significant difference in patient's demographics and perioperative results. Calculated blood loss, allogeneic blood transfusion rate, and quantity in group C were significantly higher compared with those of TXA groups (P < .001). There was no significant difference in complications rate between the 3 groups. CONCLUSIONS: According to the results of this study, IV or T administration of 1-g TXA significantly reduced the blood loss and the need for allogeneic blood transfusion in patients undergoing TKR without a tourniquet (with no significant difference between the 2 routes of administration).


Assuntos
Antifibrinolíticos/administração & dosagem , Artroplastia do Joelho/efeitos adversos , Perda Sanguínea Cirúrgica/prevenção & controle , Hemorragia Pós-Operatória/prevenção & controle , Ácido Tranexâmico/administração & dosagem , Administração Intravenosa , Administração Tópica , Idoso , Artroplastia do Joelho/métodos , Perda Sanguínea Cirúrgica/estatística & dados numéricos , Demografia , Feminino , Humanos , Infusões Intravenosas , Masculino , Pessoa de Meia-Idade , Osteoartrite do Joelho/cirurgia , Hemorragia Pós-Operatória/etiologia , Período Pós-Operatório , Estudos Prospectivos , Projetos de Pesquisa , Torniquetes/efeitos adversos , Reação Transfusional
14.
J Orthop Traumatol ; 17(2): 123-9, 2016 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-26093603

RESUMO

BACKGROUND: Patient-reported outcomes require validation in a particular language and culture before administration for clinical use. MATERIALS AND METHODS: A systematic translation of the IKDC Subjective Knee Form was initially tested in 30 patients with various knee pathologies to develop the first Greek version (IKDC/SKF-GR). It was then administered to another 80 patients. The test-retest reliability (n = 35) and internal consistency (n = 80) were examined. Construct validity was tested by correlating the IKDC/SKF-GR with the SF-36 subscales (n = 80) and content validity by measuring floor/ceiling effects. Responsiveness was measured in patients with meniscus pathology (n = 24). RESULTS: Patients filled the form without omissions/questions regarding the phrasing of items. Internal consistency was good (Cronbach's α = 0.87) and test-retest reliability very good (ICC2,1 = 0.95, SEM = 4.4 and SDC = 12.2). Correlations with the SF-36 subscales confirmed its construct validity. No floor/ceiling effects were recorded. The effect size was large (ES = 1.26). CONCLUSIONS: The IKDC/SKF-GR has comparable measurement properties to the original form. LEVEL OF EVIDENCE: Level II.


Assuntos
Características Culturais , Traumatismos do Joelho/fisiopatologia , Avaliação da Deficiência , Grécia , Humanos , Medidas de Resultados Relatados pelo Paciente , Psicometria , Reprodutibilidade dos Testes , Inquéritos e Questionários , Traduções
15.
Surg Technol Int ; 26: 307-16, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-26055025

RESUMO

Total knee replacement (TKR) is a successful procedure for pain relief and functional restoration in patients with advanced osteoarthritis. The number of TKRs is increasing, and this has led to an increase in revision surgeries. The key to long-term success in both primary and revision TKR is stability, as well as adequate and stable fixation between components and underlying bone. In the vast majority of primary TKRs and in some revision cases, a posterior cruciate retaining or a posterior cruciate substituting device can be used. In some primary cases with severe deformity or ligamentous instability and in most of the revision cases, a more constrained implant is required. The purpose of this paper is to review the literature concerning the use of condylar constrained knee (CCK) and rotating hinge (RH) implants in primary and revision cases focusing on the indications and results. According to this review, although excellent and very good results have been reported, there are limitations of the existing literature concerning the indications for the use of constrained implants, the absence of long-term results, and the limited comparative studies.


Assuntos
Artroplastia do Joelho , Prótese do Joelho , Artroplastia do Joelho/efeitos adversos , Artroplastia do Joelho/instrumentação , Artroplastia do Joelho/métodos , Humanos , Articulação do Joelho/diagnóstico por imagem , Articulação do Joelho/cirurgia , Desenho de Prótese , Falha de Prótese , Radiografia , Reoperação , Resultado do Tratamento
16.
J Orthop Traumatol ; 16(1): 35-9, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25736606

RESUMO

BACKGROUND: Vitamin D plays an important role in bone mineralization, remodeling, and maintenance and therefore its deficiency may be implicated in the pathogenesis of osteoarthritis (OA). Vitamin D status was evaluated in patients with knee or hip OA scheduled for joint replacement. The impact of anthropometric parameters such as gender, age, and body mass index on vitamin D levels was also examined. The study was conducted in a Mediterranean country (Greece). MATERIALS AND METHODS: We included 164 patients with knee or hip OA scheduled for joint replacement in this study. Serum levels of 25-hydroxyvitamin D (vitamin D) were measured in routine blood samples taken from the patients at their pre-admission visit, a week before the operation, using radioimmunoassay. RESULTS: The majority of patients were vitamin D deficient (81.7 %); 15.2 % of them were vitamin D insufficient (hypovitaminosis). Only 3 % of patients were vitamin D sufficient. There was a significantly positive association between vitamin D levels and male gender. CONCLUSION: These findings indicate a large percentage of vitamin D deficient patients with knee or hip OA, which is unexpected considering the high annual insolation in northern Greece. Many other possible predisposing factors for OA should be taken into consideration. Whether treatment with vitamin D supplements may provide beneficial effects to these patients and the stage of disease in which this treatment should commence remains an issue for further scientific investigation. LEVEL OF EVIDENCE: Level IV.


Assuntos
Osteoartrite do Quadril/complicações , Osteoartrite do Joelho/complicações , Deficiência de Vitamina D/epidemiologia , Vitamina D/análogos & derivados , Idoso , Idoso de 80 Anos ou mais , Artroplastia de Quadril , Artroplastia do Joelho , Feminino , Grécia/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade , Osteoartrite do Quadril/sangue , Osteoartrite do Quadril/cirurgia , Osteoartrite do Joelho/sangue , Osteoartrite do Joelho/cirurgia , Prevalência , Estudos Retrospectivos , Fatores de Risco , Vitamina D/sangue , Deficiência de Vitamina D/sangue , Deficiência de Vitamina D/complicações
17.
Artigo em Inglês | MEDLINE | ID: mdl-38758686

RESUMO

The management of complex and severe lower-extremity injuries is challenging for the orthopedic surgeon. When the primary or secondary closure of the defect is not feasible, complex procedures with graft (split-thickness or full-thickness) or flap (pedicled or free) are required. These procedures are performed by specialized plastic surgeons and are at high risk for adverse effects, even high morbidity among both the donor and acceptor sites. Furthermore, split-thickness skin grafts (STSGs) often lead to unsatisfactory results in terms of mechanical stability, flexibility, and aesthetics due to the lack of underlying dermal tissue. Consequently, dermal substitutes, such as MatriDerm (MedSkin Solutions Dr Suwelack AG, Billerbeck, Germany), have been proposed and further developed as a treatment option addressing the management of full-thickness wound defects in conjunction with STSGs. We aimed to present a case of post-traumatic full-thickness wound defect of the left foot after traumatic amputation of the digits that was treated with MatriDerm combined with autologous STSG. In addition, we performed a systematic review of the literature to delineate the efficacy of the use of MatriDerm combined with STSGs in orthopedic cases exclusively.


Assuntos
Transplante de Pele , Adulto , Humanos , Masculino , Amputação Traumática/cirurgia , Sulfatos de Condroitina/uso terapêutico , Colágeno/uso terapêutico , Elastina , Traumatismos do Pé/cirurgia , Transplante de Pele/métodos , Cicatrização
18.
Rheumatology (Oxford) ; 52(6): 1077-83, 2013 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23382357

RESUMO

OBJECTIVE: We sought to determine the association between plasma and SF levels of leptin and adiponectin in patients with knee OA. METHODS: Plasma and SF levels of adipokines and soluble leptin receptor (sOB-R) were determined by ELISA in 96 patients with knee OA at different stages, according to Ahlback's classification. RESULTS: Levels of adiponectin, leptin, sOB-R and free leptin in plasma and SF did not differ significantly across categories of OA severity. However, the ratio of SF to plasma leptin was significantly lower in the advanced OA stage compared with early stages of the disease (P = 0.02). After adjustment for sex and BMI, plasma leptin positively correlated with categories of OA severity (r = 0.23, P = 0.02), whereas SF/plasma leptin negatively correlated with OA stage (r = -0.27, P = 0.01). Cluster analysis showed that all men were included in one cluster and distributed in different stages of OA, whereas women formed three clusters with similar BMI, but those who were older and had the highest plasma leptin levels suffered from advanced OA. CONCLUSION: Plasma leptin positively correlated with the severity of knee OA. The ratio of SF to plasma leptin might be a marker related to the severity of knee OA. Further studies should investigate whether similar associations exist in other joints affected by OA.


Assuntos
Adipocinas/metabolismo , Osteoartrite do Joelho/metabolismo , Líquido Sinovial/metabolismo , Adipocinas/sangue , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Osteoartrite do Joelho/sangue , Receptores para Leptina/sangue , Receptores para Leptina/metabolismo , Índice de Gravidade de Doença
19.
Surg Technol Int ; 23: 251-7, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23860930

RESUMO

Tourniquets provide a bloodless field in limb operations and their introduction in orthopaedic operative technique has been considered as a landmark. A new tourniquet device, a silicone ring tourniquet (SRT) (HemaClear or S-MART, OHK Medical Devices, Haifa, Israel), was introduced into clinical practice a few years ago. A few clinical studies as well as comparative studies in volunteers have reported its use in a relatively small number of cases. The aim of this prospective study is to report the clinical use of this device in a large number of patients, including all possible applications of a tourniquet. The SRT was used in 536 cases including 337 male and 119 female patients with a mean age of 43.7 years (range 6 to 87 years). The average tourniquet time was 58.5 minutes (range 6 to 180 minutes). It was applied in 362 (67.5%) elective and in 174 (32.5%) trauma cases including fractures (n:109, 62.6%) and soft-tissue injuries (n:65, 37.4%). The most frequent application site was the femur (n:255, 47.6%), followed by the forearm (n:154, 28.7%), humerus (n:65, 12.1%), and calf (n:62, 11.6%). Because the device is sterile it was possible to use it in operations in which the pneumatic tourniquet cannot be used, such as open reduction and internal fixation of humeral shaft and femoral supracondylar fractures. In 14 patients (2.6%), the tourniquet failed intraoperatively, and the cause was an unexpected raised blood pressure. The SRT - with a pre-set pressure according to the size and the tension model - is easy to apply. It is sterile, and occupies a narrow area of the limb. Its application combines three functions at the same time: exsanguination, tourniquet, and stockinet application. Although it cannot entirely replace the classic pneumatic tourniquet, it is a safe and useful device in orthopaedic operations because of its advantages.


Assuntos
Perda Sanguínea Cirúrgica/prevenção & controle , Perda Sanguínea Cirúrgica/estatística & dados numéricos , Equipamentos Ortopédicos/estatística & dados numéricos , Silicones , Torniquetes/estatística & dados numéricos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Causalidade , Criança , Comorbidade , Desenho de Equipamento , Análise de Falha de Equipamento , Feminino , Grécia/epidemiologia , Humanos , Cuidados Intraoperatórios/instrumentação , Cuidados Intraoperatórios/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Procedimentos Ortopédicos , Prevalência , Fatores de Risco , Resultado do Tratamento , Adulto Jovem
20.
Artigo em Inglês | MEDLINE | ID: mdl-37713415

RESUMO

Plantar fasciitis is a common cause of heel pain. The aim of this study was to review the current literature and attempt to clarify whether endoscopic plantar fasciotomy (EPF) is an effective and reliable treatment for plantar fasciitis in comparison with other invasive or noninvasive treatments. We performed an electronic search of the medical literature in PubMed database using combinations of the following keywords: plantar fasciitis, endoscopic treatment, and plantar aponeurosis. Overall, we had shown that patients had better scores following EPF/endoscopic plantar fascia release. The clinical scores were improved postoperatively and most of the patients were satisfied. Furthermore, the clinical trials showed that time to return to work or to previous activities was shorter compared with other treatments. These studies suggest that EPF/endoscopic plantar fascia release is probably an effective treatment of chronic plantar fasciitis. EPF is an efficient, safe treatment with good early postoperative results in patients with recalcitrant plantar fasciitis. There is evidence that other methods are equivalently effective for EPF, and some authors support that they should be considered as a second-line treatment because of their minimal invasive character and very low risk of complications; thus, more research is required.


Assuntos
Fasciíte Plantar , Humanos , Endoscopia/métodos , Fasciíte Plantar/cirurgia , Fasciotomia/métodos , , Resultado do Tratamento
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