Detalhe da pesquisa
1.
Chemical inhibitors of hexokinase-2 enzyme reduce lactate accumulation, alter glycosylation processing, and produce altered glycoforms in CHO cell cultures.
Biotechnol Bioeng
; 120(9): 2559-2577, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37148536
2.
Microsurgery Robots: Applications, Design, and Development.
Sensors (Basel)
; 23(20)2023 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37896597
3.
Comprehensive N- and O-Glycoproteomic Analysis of Multiple Chinese Hamster Ovary Host Cell Lines.
J Proteome Res
; 21(10): 2341-2355, 2022 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36129246
4.
The interplay of protein engineering and glycoengineering to fine-tune antibody glycosylation and its impact on effector functions.
Biotechnol Bioeng
; 119(1): 102-117, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34647616
5.
Metabolic engineering challenges of extending N-glycan pathways in Chinese hamster ovary cells.
Metab Eng
; 61: 301-314, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32663509
6.
Characterization of intact glycopeptides reveals the impact of culture media on site-specific glycosylation of EPO-Fc fusion protein generated by CHO-GS cells.
Biotechnol Bioeng
; 116(9): 2303-2315, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31062865
7.
In vivo Auto-tuning of Antibody-Drug Conjugate Delivery for Effective Immunotherapy using High-Avidity, Low-Affinity Antibodies.
bioRxiv
; 2024 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38645231
8.
Optimization of therapeutic antibodies for reduced self-association and non-specific binding via interpretable machine learning.
Nat Biomed Eng
; 8(1): 45-56, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37666923
9.
Reduction of monoclonal antibody viscosity using interpretable machine learning.
MAbs
; 16(1): 2303781, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38475982
10.
Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space.
Nat Commun
; 13(1): 3788, 2022 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35778381
11.
Design and Production of Bispecific Antibodies.
Antibodies (Basel)
; 8(3)2019 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31544849