Detalhe da pesquisa
1.
Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain.
J Neurosci
; 39(3): 393-411, 2019 01 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30459229
2.
Targeting mutant KRAS.
Curr Opin Chem Biol
; 62: 101-108, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33838397
3.
Zotatifin, an eIF4A-Selective Inhibitor, Blocks Tumor Growth in Receptor Tyrosine Kinase Driven Tumors.
Front Oncol
; 11: 766298, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34900714
4.
mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation.
JCI Insight
; 6(11)2021 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34032633
5.
A Highly Selective MNK Inhibitor Rescues Deficits Associated with Fragile X Syndrome in Mice.
Neurotherapeutics
; 18(1): 624-639, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33006091
6.
Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A.
Mol Cancer Ther
; 20(1): 26-36, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33037136
7.
Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase.
J Med Chem
; 63(11): 5879-5955, 2020 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32470302
8.
Translation control of the immune checkpoint in cancer and its therapeutic targeting.
Nat Med
; 25(2): 301-311, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30643286
9.
Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.
J Med Chem
; 61(8): 3516-3540, 2018 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29526098
10.
Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities.
J Med Chem
; 45(18): 3905-27, 2002 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-12190313
11.
N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent.
J Med Chem
; 47(7): 1719-28, 2004 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-15027863
12.
Correction to N-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent.
J Med Chem
; 58(18): 7609, 2015 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26328598
13.
1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues.
Bioorg Med Chem Lett
; 13(14): 2405-8, 2003 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12824044
14.
1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases.
Bioorg Med Chem Lett
; 13(6): 1133-6, 2003 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-12643928
15.
Synthesis and biological activity of N-aryl-2-aminothiazoles: potent pan inhibitors of cyclin-dependent kinases.
Bioorg Med Chem Lett
; 14(11): 2973-7, 2004 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-15125971