Detalhe da pesquisa
1.
Simultaneous targeting of glycolysis and oxidative phosphorylation as a therapeutic strategy to treat diffuse large B-cell lymphoma.
Br J Cancer
; 127(5): 937-947, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35618788
2.
Highly Potent Clickable Probe for Cellular Imaging of MDM2 and Assessing Dynamic Responses to MDM2-p53 Inhibition.
Bioconjug Chem
; 29(6): 2100-2106, 2018 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29851469
3.
Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach.
Org Biomol Chem
; 16(11): 1843-1850, 2018 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29469144
4.
Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma.
Haematologica
; 102(7): 1247-1257, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28385782
5.
Mechanisms that influence tumour response to VEGF-pathway inhibitors.
Biochem Soc Trans
; 42(6): 1601-7, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25399577
6.
Modulation of ERK5 Activity as a Therapeutic Anti-Cancer Strategy.
J Med Chem
; 66(7): 4491-4502, 2023 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37002872
7.
Fragment expansion with NUDELs - poised DNA-encoded libraries.
Chem Sci
; 14(31): 8288-8294, 2023 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37564419
8.
Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release.
J Med Chem
; 66(17): 12324-12341, 2023 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37647129
9.
A Phase I Dose-escalation Study of AZD3965, an Oral Monocarboxylate Transporter 1 Inhibitor, in Patients with Advanced Cancer.
Clin Cancer Res
; 29(8): 1429-1439, 2023 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36652553
10.
Expression of stromal genes associated with the angiogenic response are not differentiated between human tumour xenografts with divergent vascular morphologies.
Angiogenesis
; 15(4): 555-68, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22644562
11.
Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor.
J Med Chem
; 65(9): 6513-6540, 2022 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35468293
12.
DNAPK Inhibition Preferentially Compromises the Repair of Radiation-induced DNA Double-strand Breaks in Chronically Hypoxic Tumor Cells in Xenograft Models.
Mol Cancer Ther
; 20(9): 1663-1671, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34158348
13.
An Alkynylpyrimidine-Based Covalent Inhibitor That Targets a Unique Cysteine in NF-κB-Inducing Kinase.
J Med Chem
; 64(14): 10001-10018, 2021 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34212719
14.
Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction.
J Med Chem
; 64(7): 4071-4088, 2021 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33761253
15.
Placental growth factor neutralising antibodies give limited anti-angiogenic effects in an in vitro organotypic angiogenesis model.
Angiogenesis
; 13(4): 337-47, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20953695
16.
Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy.
J Clin Invest
; 130(1): 258-271, 2020 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31581151
17.
Use of a novel Arg-Gly-Asp radioligand, 18F-AH111585, to determine changes in tumor vascularity after antitumor therapy.
J Nucl Med
; 50(1): 116-22, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19091899
18.
Inhibition of vascular endothelial growth factor-a signaling induces hypertension: examining the effect of cediranib (recentin; AZD2171) treatment on blood pressure in rat and the use of concomitant antihypertensive therapy.
Clin Cancer Res
; 14(10): 3124-31, 2008 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18483380
19.
The use and refinement of rodent models in anti-cancer drug discovery: a review.
Altern Lab Anim
; 37(2): 173-80, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19453212
20.
Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc(Min/+) mice.
Mol Cancer Ther
; 7(3): 590-8, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18347145