Detalhe da pesquisa
1.
LOAd703, an oncolytic virus-based immunostimulatory gene therapy, combined with chemotherapy for unresectable or metastatic pancreatic cancer (LOKON001): results from arm 1 of a non-randomised, single-centre, phase 1/2 study.
Lancet Oncol
; 25(4): 488-500, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38547893
2.
CD40 stimulation via CD40 ligand enhances adenovirus-mediated tumour immunogenicity including 'find-me', 'eat-me', and 'kill-me' signalling.
J Cell Mol Med
; 28(7): e18162, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38494863
3.
Immunostimulatory gene therapy targeting CD40, 4-1BB and IL-2R activates DCs and stimulates antigen-specific T-cell and NK-cell responses in melanoma models.
J Transl Med
; 21(1): 506, 2023 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37501121
4.
Boosting CAR T-cell responses in lymphoma by simultaneous targeting of CD40/4-1BB using oncolytic viral gene therapy.
Cancer Immunol Immunother
; 70(10): 2851-2865, 2021 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-33666760
5.
IL-6 Signaling Blockade during CD40-Mediated Immune Activation Favors Antitumor Factors by Reducing TGF-ß, Collagen Type I, and PD-L1/PD-1.
J Immunol
; 202(3): 787-798, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30617223
6.
Gemcitabine reduces MDSCs, tregs and TGFß-1 while restoring the teff/treg ratio in patients with pancreatic cancer.
J Transl Med
; 14(1): 282, 2016 Sep 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-27687804
7.
Immune priming using DC- and T cell-targeting gene therapy sensitizes both treated and distant B16 tumors to checkpoint inhibition.
Mol Ther Oncolytics
; 24: 429-442, 2022 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35141399
8.
Systemic immunity upon local oncolytic virotherapy armed with immunostimulatory genes may be supported by tumor-derived exosomes.
Mol Ther Oncolytics
; 20: 508-518, 2021 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33738337
9.
Intratumoral immunostimulatory AdCD40L gene therapy in patients with advanced solid tumors.
Cancer Gene Ther
; 28(10-11): 1188-1197, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33318679
10.
Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40.
Cancer Gene Ther
; 27(12): 948-959, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32355275
11.
A Phase I/IIa Trial Using CD19-Targeted Third-Generation CAR T Cells for Lymphoma and Leukemia.
Clin Cancer Res
; 24(24): 6185-6194, 2018 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30097433
12.
Local irradiation does not enhance the effect of immunostimulatory AdCD40L gene therapy combined with low dose cyclophosphamide in melanoma patients.
Oncotarget
; 8(45): 78573-78587, 2017 Oct 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29108250
13.
Shaping the Tumor Stroma and Sparking Immune Activation by CD40 and 4-1BB Signaling Induced by an Armed Oncolytic Virus.
Clin Cancer Res
; 23(19): 5846-5857, 2017 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28536305