Detalhe da pesquisa
1.
Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription.
Genes Dev
; 34(21-22): 1452-1473, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33060135
2.
Molecular mechanism by which a potent hepatitis C virus NS3-NS4A protease inhibitor overcomes emergence of resistance.
J Biol Chem
; 288(8): 5673-81, 2013 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23271737
3.
Evaluation of phosphatidylinositol-4-kinase IIIα as a hepatitis C virus drug target.
J Virol
; 86(21): 11595-607, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22896614
4.
Peptide backbone replacement of hepatitis C virus NS3 serine protease C-terminal cleavage product analogs: discovery of potent succinamide inhibitors.
Bioorg Med Chem Lett
; 23(15): 4447-52, 2013 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23773863
5.
Synthesis and optimization of a novel series of HCV NS3 protease inhibitors: 4-arylproline analogs.
Bioorg Med Chem Lett
; 23(14): 4267-71, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23735741
6.
Combined X-ray, NMR, and kinetic analyses reveal uncommon binding characteristics of the hepatitis C virus NS3-NS4A protease inhibitor BI 201335.
J Biol Chem
; 286(13): 11434-43, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21270126
7.
In vitro resistance profile of the hepatitis C virus NS3 protease inhibitor BI 201335.
Antimicrob Agents Chemother
; 56(1): 569-72, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22024816
8.
The liver partition coefficient-corrected inhibitory quotient and the pharmacokinetic-pharmacodynamic relationship of directly acting anti-hepatitis C virus agents in humans.
Antimicrob Agents Chemother
; 56(10): 5381-6, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22869578
9.
Small molecule inhibitors of the human papillomavirus E1-E2 interaction.
Curr Top Microbiol Immunol
; 348: 61-88, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-20676971
10.
Cross-species absorption, metabolism, distribution and pharmacokinetics of BI 201335, a potent HCV genotype 1 NS3/4A protease inhibitor.
Xenobiotica
; 42(2): 164-72, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21988548
11.
Potency, safety, and pharmacokinetics of the NS3/4A protease inhibitor BI201335 in patients with chronic HCV genotype-1 infection.
J Hepatol
; 54(6): 1114-22, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21145839
12.
Preclinical characterization of BI 201335, a C-terminal carboxylic acid inhibitor of the hepatitis C virus NS3-NS4A protease.
Antimicrob Agents Chemother
; 54(11): 4611-8, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20823284
13.
Protease and helicase activities of hepatitis C virus genotype 4, 5, and 6 NS3-NS4A proteins.
Biochem Biophys Res Commun
; 391(1): 692-7, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19944069
14.
Structure-thermodynamics-relationships of hepatitis C viral NS3 protease inhibitors.
Eur J Med Chem
; 192: 112195, 2020 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32151833
15.
Use of the fused NS4A peptide-NS3 protease domain to study the importance of the helicase domain for protease inhibitor binding to hepatitis C virus NS3-NS4A.
Biochemistry
; 48(4): 744-53, 2009 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-19119853
16.
Radiolucent Triangle as a Positioning Tool to Simplify Prone Ankle Fracture Surgery.
Foot Ankle Spec
; 10(1): 51-54, 2017 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-27798067
17.
Discovery of small-molecule inhibitors of the ATPase activity of human papillomavirus E1 helicase.
J Med Chem
; 47(1): 18-21, 2004 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-14695816
18.
Human rhinovirus VPg uridylylation AlphaScreen for high-throughput screening.
J Biomol Screen
; 19(2): 259-69, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23813021
19.
Discovery of hepatitis C virus NS3-4A protease inhibitors with improved barrier to resistance and favorable liver distribution.
J Med Chem
; 57(5): 1770-6, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23506530
20.
Blunting the Swiss army knife of hepatitis C virus: inhibitors of NS3/4A protease.
Prog Med Chem
; 44: 65-107, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16697895