Detalhe da pesquisa
1.
DrugMap: A quantitative pan-cancer analysis of cysteine ligandability.
Cell
; 187(10): 2536-2556.e30, 2024 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38653237
2.
Discovery of 6-Oxo-4-phenyl-hexanoic acid derivatives as RORγt inverse agonists showing favorable ADME profile.
Bioorg Med Chem Lett
; 36: 127786, 2021 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33493627
3.
Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious ß-secretase inhibitors for the potential treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 25(4): 767-74, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25613679
4.
Examining the Influence of Physician Assistant/Associate Scope of Practice Reforms and Individual Characteristics on Wages.
Med Care Res Rev
; 80(4): 386-395, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37340800
5.
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis.
Neuron
; 49(2): 191-203, 2006 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-16423694
6.
Discovery of [1,2,4]Triazolo[1,5-a]pyridine Derivatives as Potent and Orally Bioavailable RORγt Inverse Agonists.
ACS Med Chem Lett
; 11(4): 528-534, 2020 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32292560
7.
Discovery of alpha-amidosulfones as potent and selective agonists of CB2: synthesis, SAR, and pharmacokinetic properties.
Bioorg Med Chem Lett
; 19(1): 31-5, 2009 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19062274
8.
Mice lacking ghrelin receptors resist the development of diet-induced obesity.
J Clin Invest
; 115(12): 3564-72, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16322794
9.
Discovery of aryl aminoquinazoline pyridones as potent, selective, and orally efficacious inhibitors of receptor tyrosine kinase c-Kit.
J Med Chem
; 51(11): 3065-8, 2008 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18447379
10.
Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: design, synthesis, and evaluation.
J Med Chem
; 51(6): 1649-67, 2008 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-18324761
11.
Structural modifications of N-arylamide oxadiazoles: Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2.
Bioorg Med Chem Lett
; 18(15): 4267-74, 2008 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18640038
12.
Smartphone-based Arrhythmia Detection: Should we encourage patients to use the ECG in their pocket?
J Atr Fibrillation
; 9(6): 1605, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29250298
13.
Development of 2-aminooxazoline 3-azaxanthene ß-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D.
Medchemcomm
; 8(6): 1196-1206, 2017 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108829
14.
Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity.
J Med Chem
; 49(16): 4981-91, 2006 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-16884310
15.
Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity.
J Med Chem
; 49(19): 5671-86, 2006 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-16970394
16.
The effect of the amiodarone-warfarin interaction on anticoagulation quality in a single, high-quality anticoagulation center.
Blood Coagul Fibrinolysis
; 27(2): 147-50, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26258678
17.
Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate.
PLoS One
; 11(2): e0147254, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26840340
18.
An Orally Available BACE1 Inhibitor That Affords Robust CNS Aß Reduction without Cardiovascular Liabilities.
ACS Med Chem Lett
; 6(2): 210-5, 2015 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25699151
19.
Total synthesis of (+/-)-kalihinol C.
Org Lett
; 6(7): 1123-6, 2004 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15040738
20.
Lead optimization and modulation of hERG activity in a series of aminooxazoline xanthene ß-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.
J Med Chem
; 57(23): 9796-810, 2014 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25389560