High-Intensity Conditioning Activity Causes Localized Postactivation Performance Enhancement and Nonlocalized Performance Reduction.

ABSTRACT: Kolinger D, Stastny P, Pisz A, Krzysztofik M, Wilk M, Tsoukos A, and Bogdanis GC. High-intensity conditioning activity causes localized postactivation performance enhancement and nonlocalized performance reduction. J Strength Cond Res 38(1): e1-e7, 2024-This study aimed to examine whether a conditioning activity (CA) performed by the legs (barbell back squat) may cause postactivation performance enhancement (PAPE) on muscle groups other than leg extensors in isokinetic (eccentric [ECC] and concentric [CON]) and dynamic movement. Twelve male basketball players (age: 21.3 ± 3.2, body mass: 89.6 ± 14.1 kg, height: 187.4 ± 4.6 cm, and 1 repetition maximum (1RM) barbell back squat: 113 ± 21 kg) with previous resistance-training experience of at least 2 years, performed 3 sets of 3-4 repetitions of back-squats with submaximal load (60, 90, and 90% 1RM) as CA. Before and after the CA, they performed pretest and post-test in the form of countermovement jumps (CMJs) (localized) or explosive push-ups (EPUs) (nonlocalized) along with isokinetic flexion and extension at the knee (localized) or at the elbow (nonlocalized). The localized and nonlocalized protocols were divided into 2 days in a randomized order. The back squat as CA significantly increased peak torque (PT) (p < 0.05) in all CON and ECC muscle actions and average power per repetition (APPR) (p < 0.05) (all muscle actions except ECC flexion) of the localized isokinetic tests with large (>0.8) and medium (0.4-0.79) effect sizes and significantly decreased (p < 0.01) the PT and APPR (p < 0.01) of the nonlocalized isokinetic test in the ECC flexion. The CMJ and EPU tests showed no significant differences (p > 0.05) between premeasures and postmeasures of take-off height. The effect of PAPE seems to be specific to the muscles most involved in the CA, and the CA inhibits PT of subsequent muscle ECC contractions in muscles not involved in the CA.

Effects of different ischemic pressures on bar velocity during the bench press exercise: A randomized crossover trial.

The main objective of this study was to evaluate the effects of different ischemic pressures applied during rest intervals on bar velocity during the bench press exercise. 10 resistance-trained males (age = 23.2 ± 2.7 years; body mass = 83.9 ± 9 kg; body height = 181 ± 5.2 cm; bench press 1 repetition maximum (1RM) = 125 ± 16.4 kg; training experience = 5.4 ± 3.4 years) participated in the study. During 4 experimental sessions, following a randomized crossover design, the subjects performed 5 sets of 3 repetitions of the bench press exercise with a load of 60% 1RM under conditions: with ischemia (50% or 80% of arterial occlusion pressure), with SHAM ischemia (20 mmHg) and without ischemia (control condition). For the ischemic conditions cuffs were applied before each set for 6.5 min and released 30 s before the start of the set as reperfusion (6.5 min ischemia + 0.5 min reperfusion). In the control condition, ischemia was not applied. The two-way repeated measures ANOVA showed no significant condition × set interaction for mean bar velocity (MV; p = 0.17) and peak bar velocity (PV; p = 0.66). There was also no main effect of condition for MV (p = 0.58) and PV (p = 0.61). The results indicate that ischemic or SHAM treatment (6.5 minutes ischemia or SHAM + 30 s reperfusion) does not affect mean and peak bar velocity during the bench press exercise regardless of the applied pressure.

Acute Effects of Isometric Conditioning Activity on the Viscoelastic Properties of Muscles and Sprint and Jumping Performance in Handball Players.

ABSTRACT: Krzysztofik, M, Spieszny, M, Trybulski, R, Wilk, M, Pisz, A, Kolinger, D, Filip-Stachnik, A, and Stastny, P. Acute effects of isometric conditioning activity on the viscoelastic properties of muscles and sprint and jumping performance in handball players. J Strength Cond Res 37(7): 1486-1494, 2023-The effects of conditioning activity (CA) on muscle stiffness are currently unknown, suggesting that maximum CA effort can increase or decrease the stiffness of involved muscle groups. Therefore, this study aimed to investigate the effect of maximal isometric half-squats on the viscoelastic properties of muscles and postactivation performance enhancement (PAPE) in sprints and jumps. Twelve handball players underwent a standard warm-up and baseline assessment of muscle stiffness and tone of vastus lateralis and gastrocnemius medialis muscle, followed by 20-m sprint with intermediate measures at 5 and 10 m and countermovement jump. The PAPE was assessed by repeating the tests (at 4th, 8th, and 12th minute post-CA) after a CA protocol consisting of 3 sets of 3-second maximal isometric half-squats (EXP) or a control condition (CTRL) without any CA. The vastus lateralis stiffness in the 4th and 12th minute and muscle tone in the 4th minute post-CA significantly decreased compared with baseline ( p = 0.041, ES = 0.57; p = 0.013, ES = 0.52; p = 0.004, ES = 0.81, respectively) in the EXP condition. The 20-m sprint time significantly decreased at all post-CA time points compared with the baseline for the EXP condition ( p < 0.033) and the after values in the CTRL condition ( p < 0.036). In comparison to baseline, the 10-m sprint time decreased in the eighth minute post-CA ( p = 0.021; ES = 0.82) in the EXP condition. Moreover, it was significantly lower at the 8th and 12th minute post-CA ( p = 0.038; ES = 0.71 and p = 0.005; ES = 1.26) compared with that time points in the CTRL condition. The maximal isometric half-squats effectively improved sprint performance and significantly decreased vastus lateralis tone and stiffness. These findings offer new insights into the assessment of viscoelastic properties for evaluating the fatigue or potentiation state, which requires further investigation.

Acute Effects of Varied Back Squat Activation Protocols on Muscle-Tendon Stiffness and Jumping Performance.

ABSTRACT: Krzysztofik, M, Wilk, M, Pisz, A, Kolinger, D, Tsoukos, A, Zajac, A, Stastny, P, and Bogdanis, GC. Acute effects of varied back squat activation protocols on muscle-tendon stiffness and jumping performance. J Strength Cond Res 37(7): 1419-1427, 2023-Intensity, movement velocity, and volume are the principal factors to successfully use postactivation performance enhancement. Therefore, 15 resistance-trained volleyball players completed 3 different back squat configurations as a conditioning activity (CA) in randomized order: (a) 3 sets of 3 repetitions at 85% 1RM (HL); (b) a single set of back squats at 60% 1RM until 10% mean velocity loss (VB); (c) and 2 sets of back squats at 60% 1RM until 10% mean velocity loss (2VB) on subsequent countermovement jump performance, Achilles tendon, and vastus lateralis stiffness with concomitant front thigh skin surface temperature assessment. The measurements were performed 5 minutes before the CA and at 2, 4, 6, 8, and 10 minutes. The jump height was significantly increased in the second minute and at peak, post-CA compared with baseline for all conditions ( p = 0.049; ES = 0.23 and p < 0.001; ES = 0.37). Skin surface temperature was significantly increased for all post-CA time points compared with baseline in the 2VB condition ( p from <0.001-0.023; ES = 0.39-1.04) and in the fourth minute and at peak post-CA in HL condition ( p = 0.023; ES = 0.69 and p = 0.04; ES = 0.46), whereas for the VB condition, a significant decrease in peak post-CA was found ( p = 0.004; ES = -0.54). Achilles tendon stiffness was significantly decreased for second, fourth, eighth, 10th, and peak post-CA in comparison to baseline for all conditions ( p from p = 0.004-0.038; ES = -0.47 to -0.69). Vastus lateralis stiffness was significantly decreased for peak post-CA compared with baseline for all conditions ( p = 0.017; ES = -0.42). We recommend using a single set of barbell squats with a 10% velocity loss as a mechanism of fatigue control to acutely improve jump height performance and avoid unnecessary increases in training volume.

Acute Effects of High-Load vs. Plyometric Conditioning Activity on Jumping Performance and the Muscle-Tendon Mechanical Properties.

ABSTRACT: Krzysztofik, M, Wilk, M, Pisz, A, Kolinger, D, Bichowska, M, Zajac, A, and Stastny, P. Acute effects of high-load versus plyometric conditioning activity on jumping performance and the muscle-tendon mechanical properties. J Strength Cond Res 37(7): 1397-1403, 2023-The effectiveness of high-load and plyometric exercises as conditioning activity (CA) is not well described in the level of performance enhancement and muscle-tendon properties. Therefore, this study aimed to compare the effectiveness of high-loaded back squats and body mass tuck jumps among amateur soccer players on the height of countermovement jump performed without (CMJ) and with arm swing (CMJa) and to verify the usefulness of the myotonometry in assessing the level of CA-induced fatigue. Therefore, 16 male amateur soccer players (resistance training experience: 2 ± 1 year, relative 1 repetition maximum back squat strength: 1.41 ± 0.12 kg·body mass-1) performed 3 experimental sessions to compare the acute effects of 3 sets of 3 repetitions at 85% one repetition maximum of half back squats (HL), 3 sets of 5 repetitions of tuck jump exercises (PLY), and no CA (CTRL) on CMJ and CMJa height. Moreover, the gastrocnemius medialis and Achilles tendon tone and stiffness were examined. Measurements were performed 5 minutes before CA and in the third, sixth, and ninth minutes after CA. The CMJ height significantly increased from pre-CA to post-CA in the CTRL (p = 0.005; effect size [ES] = 0.36; Δ = +3.4%) and PLY (p = 0.001; ES = 0.83; Δ = +8.8%) conditions. Moreover, post-CA jump height was significantly higher in PLY than in the HL condition (p = 0.024; ES = 0.6; Δ = +5.9%). No significant differences were found for CMJa height, tone, and stiffness of gastrocnemius medialis and Achilles tendon. The low-volume plyometric CA (i.e., 3 sets of 5 repetitions) is recommended instead of high-loaded CA (≥85% one repetition maximum) for amateur athletes. In addition, it has been established that the performance improvement was independent of changes in the mechanical properties of the gastrocnemius medialis and Achilles tendon. Furthermore, it seems that the complexity of the post-CA task may affect the magnitude of the postactivation performance enhancement.

Cardiac Biomarkers and Geriatric Assessment in Metastatic Castrate-Resistant Prostate Cancer During Abiraterone Acetate Therapy - A Cardio-Oncology Study.

BACKGROUND: Abiraterone acetate (AA) is a drug used in advanced prostate cancer. However, known clinical factors with predictive and prognostic value are scarce. This study evaluated cardiovascular (CV) factors and geriatric scales as potential markers of superior response during AA therapy. METHODS: This is a prospective observational study. Serum levels of high sensitivity troponin T (hsTnT), D-dimer, NT-proBNP and left ventricle ejection fraction (LVEF) were used for CV evaluation. Questionnaires of G8, VES-13, Activities of Daily Living (ADL), Instrumental Activities of Daily Living (iADL), and Geriatric Depression Scale (GDS) were included in the geriatric screening assessment. All measures were taken before AA initiation. Survival curves and Cox proportional hazard models (univariate and multivariate) were used to determine the predictors for a longer time to treatment failure (TTF). RESULTS: Forty nine patients were included in the study. Overall median TTF was 7.9 months (95% CI: 5.9-12.4). In univariate analysis, factors associated with inferior TTF were (P-value < .05): visceral metastases - HR 2.34; 95% CI: 1.24-4.45, history of coronary artery disease - HR 3.02; 95% CI: 1.19-7.66; LVEF < 50% - HR 2.53; 95% CI: 1.03-6.17; P = .041; age-adjusted D-dimer > upper reference limit (URL) - HR 3.53; 95% CI: 1.81-6.85; P < .001; hsTnT > URL - HR 2.17; 95% CI: 1.13-4.16; P = .016; NT-proBNP ≥ 300 pg/mL - HR 2.3; 95% CI: 1.22-4.34; P = .01; G8 score ≤14 points - HR 2.47; 95% CI: 1.29-4.74; P = .007. In multivariate analysis, age-adjusted D-dimer > URL, G8 score ≤ 14 points and visceral metastases remained statistically significant in prediction of inferior TTF. The number of these factors was associated with shorter median TTF: 0-1 factor - 14.1 months; 2 factors - 5.9 months; 3 factors - 2.7 months; P < .001, log-rank). CONCLUSIONS: Age-adjusted D-dimer, and geriatric G8 scores may predict TTF in men with metastatic castration-resistant prostate cancer during AA therapy. These observations require further study in a larger population.

Acute effects of two caffeine doses on bar velocity during the bench press exercise among women habituated to caffeine: a randomized, crossover, double-blind study involving control and placebo conditions.

PURPOSE: The main goal of this study was to evaluate the effectiveness of two different doses of caffeine (3 and 6 mg/kg) to enhance bar velocity during the bench press in women habituated to caffeine. METHODS: Twelve recreationally trained women (age: 23.3 ± 0.8 years, body mass: 60.7 ± 5.7 kg, bench press one-repetition maximum (1RM): 44.3 ± 7.8 kg, daily caffeine ingestion: 5.7 ± 2.0 mg/kg/day) participated in a randomized double-blind experimental design. Each participant performed four different experimental sessions: after no supplementation (control, CON), after ingesting 3 and 6 mg/kg of caffeine (CAF-3 and CAF-6, respectively), or after ingesting a placebo (PLAC). In each experimental session, the participants performed 3 sets of 3 repetitions of the bench press exercise at 50% 1RM. RESULTS: A two-way repeated-measures ANOVA with subsequent post hoc analyses indicated significant increases in peak velocity (p < 0.01; ES = 0.91) and mean velocity (p < 0.01; ES = 0.78) after the intake of CAF-6 compared to CON. The study did not show significant differences in bar velocity between CAF-6 and PLAC and between CAF-3 and PLAC. No significant differences in bar velocity were observed between CAF-3 and CAF-6 conditions. CONCLUSION: These results suggest that 6 mg/kg of caffeine can be an effective dose to improve power-specific training outcomes in women habituated to caffeine. However, the ergogenic effect of 6 mg/kg of caffeine may be derived from a combination of biological effects and expectancy, as this dose was only superior to the control condition with no differences over the placebo.

Management of Anticoagulation in Cancer Patients with Atrial Fibrillation.

BACKGROUND: Atrial fibrillation is becoming an increasingly important problem in cardio-oncology. Specific risk factors for atrial fibrillation occurrence include type of cancer disease and anticancer drugs. Anticoagulation is often abandoned. The CHA2DS2-VASc and CHA2DS2 scores may be important not only in predicting stroke but also in mortality. The role of new direct oral anticoagulants is growing, but they need to be used in a personalized approach depending on the risk of unbeneficial interactions with cancer treatment and the risk of bleeding.

Postactivation Performance Enhancement of Concentric Bench Press Throw After Eccentric-Only Conditioning Exercise.

ABSTRACT: Krzysztofik, M, Wilk, M, Lockie, RG, Golas, A, Zajac, A, and Bogdanis, GC. Postactivation performance enhancement of concentric bench press throw after eccentric-only conditioning exercise. J Strength Cond Res 36(8): 2077-2081, 2022-This study examined changes in power output and bar velocity in the concentric-only bench press throw (CON ONLY ) after sets of eccentric-only bench press exercises (ECC ONLY ) at 2 supramaximal loads. Thirteen strength-trained men participated in this study (age = 25.7 ± 1.9 years, body mass = 94.8 ± 8 kg, 1 repetition maximum [1RM] = 147 ± 14.2 kg, and strength training experience = 6.5 ± 2.2 years). The subjects performed 2 conditioning sets of the bench press exercise of 2 repetitions each, with a 5-minute rest interval between sets, using the ECC ONLY mode against 110% or 130% of concentric 1RM load. The 1 repetition of the CON ONLY bench press throw with a load of 30% 1RM was performed before and 5 minutes after the conditioning activity (CA) to assess changes in peak power (PP) and peak velocity (PV). The differences between the analyzed variables before and after the CA were determined using a 2-way repeated measures analysis of variance. There was an increase of PP by 10.5 ± 6.0% (effect size [ES] = 0.34) and 9.9 ± 8.1% (ES = 0.33) for the 110 and 130% of concentric 1RM conditions, respectively, with no difference between the 2 conditions ( p < 0.01 main effect time, no interaction). Similarly, PV increased by 5.9 ± 5.5% (ES = 0.40) and 6.1 ± 6.1% (ES = 0.43) for the 110 and 130% of concentric 1RM conditions, respectively, with no difference between the 2 conditions ( p < 0.01 main effect time, no interaction). Activation with an ECC ONLY contraction and loads exceeding 1RM are effective at improving power output and bar velocity during the CON ONLY bench press throw.

Short-Term Blood Flow Restriction Increases Power Output and Bar Velocity During the Bench Press.

ABSTRACT: Wilk, M, Krzysztofik, M, Filip, A, Zajac, A, Bogdanis, GC, and Lockie, RG. Short-term blood flow restriction increases power output and bar velocity during the bench press. J Strength Cond Res 36(8): 2082-2088, 2022-This study examined the effect of blood flow restriction (BFR) with 2 different types of cuffs on peak power output (PP), mean power output (MP), peak bar velocity (PV), and mean bar velocity (MV) in the bench press exercise (BP). Fourteen healthy strength-trained male athletes (age = 27.6 ± 3.5 years; body mass = 84.1 ± 8.0 kg; height = 175.8 ± 6.7 cm; BP 1 repetition maximum [RM] = 138.6 ± 17.8 kg) performed 3 different testing protocols as follows: without BFR (NO-BFR), BFR with a narrow cuff (BFR NARROW ), and BFR with a wide cuff (BFR WIDE ) in a randomized crossover design. During all sessions, subjects performed one set of 3 repetitions of the BP exercise using 70% 1RM. Cuff pressure was set to approximately 90% full arterial occlusion pressure of the upper limb at rest. Analyses of variance showed an increase in PP (by 21%, p < 0.01; effect size [ES] = 1.67), MP (by 16%, p < 0.01; ES = 0.93), PV (by 22%, p < 0.01; ES = 1.79), and MV (by 21%, p < 0.01; ES = 1.36) during BFR WIDE compared with NO-BFR and a significant increase in PP (by 15%, p < 0.01; ES = 1.07), MP (by 17%, p < 0.01; ES = 0.78), PV (by 18%, p < 0.01; ES = 1.65), and MV (by 13% p < 0.01; ES = 1.00) during BFR WIDE compared with BFR NARROW . There were no significant differences in any of the variable between NO-BFR and BFR NARROW . The results of the study indicate that short-term BFR training increases power output and bar velocity during the BP exercise. However, only BFR WIDE significantly influenced bar velocity and power output, which indicates that the width of the cuff is a critical factor determining acute exercise adaptation during BFR resistance training.

Speed and power-related gene polymorphisms associated with playing position in elite soccer players.

Heritability studies on sport-related traits accepted that endurance, speed, power, and strength abilities include an active genetic predisposition to elite soccer participation. This study evaluates the influence of selected genetic variants on performance in speed, power, and strength laboratory tests on a group of elite soccer players, including their playing position. A ninety-nine male elite soccer players were compared to controls (n = 107) and tested for quadriceps and hamstrings isokinetic strength at speed 60°/s, 180°/s, and 300°/s, jump performance, and genotypes of ACTN3 (R577X, rs1815739), ACE (I/D, rs1799752), NOS3 (Glu298Asp, rs1799983), AMPD1 (34C/T, rs17602729), UCP2 (Ala55Val, rs660339), BDKRB2 (+9/-9, rs5810761) and IL1RN (VNTR 86-bp). The ACTN3 XX homozygotes in defenders had lower quadriceps and hamstring isokinetic strength in all tested speeds than ACTN3 RX and RR genotypes (p < 0.05). The ACTN3 RR homozygotes in defenders had higher quadriceps strength in all tested velocities than the RX heterozygotes (p < 0.05). We also found other associations between playing-position in soccer and increased strength of lower limbs for AMPD1 CC and NOS3 Glu/Glu genotypes, and IL1RN*2 allele carriers. Total genetic score regression explained 26% of the variance in jump performance and isokinetic strength. The ACTN3 R allele, NOS3 Glu/Glu genotypes, and IL1RN*2 allele pre-disposed the attackers and defenders playing position in elite soccer, where those positions have higher strength and power measures than midfielders. Midfielders have lower strength and power conditions than other playing positions without relation to strength and power genes.

Impact of movement tempo on bar velocity and time under tension in resistance exercises with different external loads.

The goal of the study was to determine the differences between volitional and maximal movement tempo during resistance exercise. Ten healthy men volunteered for the study (age = 26.4 ± 4.8 years; body mass = 93.8 ± 9.6 kg; barbell squat one-repetition maximum (1RM) = 175 ± 16.7 kg; bench press 1RM = 140.5 ± 26.8 kg). In a randomized order, the participants performed six sets of the barbell squat and the bench press exercise at progressive loads from 40% to 90%1RM (step by 10%) under two testing conditions: with volitional movement tempo or with maximal movement tempo. The three-way repeated measures ANOVA showed a statistically significant multi-interaction effect for time under tension (p < 0.001), peak bar velocity (p = 0.04) and for mean bar velocity (p < 0.001). There was also a statistically significant main effect of movement tempo for time under tension (p < 0.001), peak bar velocity (p < 0.001) and for mean bar velocity (p < 0.001). The post hoc analysis for main effect of tempo revealed that time under tension was significantly longer for volitional compared to maximal tempo (0.84 vs 0.67 s, respectively), peak bar velocity was significantly higher for maximal compared to volitional tempo (1.24 m/s vs 0.90 m/s, respectively), and mean bar velocity was significant higher for maximal compared to volitional tempo (0.84 m/s vs 0.67 m/s, respectively). The presented results indicate that there were significant differences between volitional and maximal movement tempos in time under tension and bar velocity (peak and mean), as well as significant differences in those variables between the two exercises. Therefore, the velocity of movement and time under tension is related to movement tempo, external load and type of exercise used.

Effects of Unilateral Conditioning Activity on Acute Performance Enhancement: A Systematic Review.

This review aimed to summarize the reported effects of unilateral conditioning activity (CA) on unilateral performance, bilateral performance, and the contribution of activated body limb to bilateral performance. A systematic search on MEDLINE, SPORTDiscus, Scopus, and Google Scholar was conducted on February 2022. Twenty-three studies met the inclusion criteria. Throwing, jumping, swimming, change of direction, and isokinetic performance were used as outcome measures to assess the impact of unilateral CAs on inducing post-activation performance enhancement. Eleven studies examined the effectiveness of resistance exercises as a CA, seven investigated plyometric exercises, and five used isokinetic muscle actions as CAs. Notably, only three studies directly compared the effects of bilateral and unilateral CA, and no study reported possible changes in the contribution of each limb during bilateral exercises executed following unilateral CA. Split squats were the most often studied CA (7), and it was shown that multiple sets of high-loaded split squats (85% one-repetition maximum) executed as CA, improve vertical jumping and change of direction after 4 to 8 min of recovery. At the same time, multiple sets of alternate leg bounds performed with ~10% body weight or without any external load result in an improvement of sprint performance, 2 and 8 min later, with the effect being greater when loaded jumps are used. The unilateral CAs such as split squats, alternate leg bounds, and drop jumps can be effectively used to acutely improve a wide variety of athletic tasks, including jumping, sprinting, change of direction, and swimming performance.

Changes in EMG and movement velocity during a set to failure against different loads in the bench press exercise.

This study examined changes in movement velocity and surface electromyographic (sEMG) activity of the pectoralis major (PM) and triceps brachii (TB) muscles during the bench press exercise to failure against different loads. Fourteen men performed a set to failure with maximum intended velocity, against low (40%-1 repetition maximum-RM), moderate (60%-1RM), and heavy loads (80%-1RM). Number of repetitions, volume load, mean and peak velocity, and total time increased with decreasing load (40% > 60% > 80%, p < 0.01). sEMG comparisons between different loads were performed by matching time under tension at the initial, middle, and last part of the set. sEMG was higher in the middle and last repetitions, compared with the initial, for all loads in both muscles (p < 0.001). sEMG activity of both muscles was higher in the 60% and 80%-1RM conditions compared with the 40%1-RM (p < 0.007). Also, sEMG of both muscles was similar for the 60%-1RM and 80%-1RM loads at the initial, middle, and last repetitions, with the exception of the last repetitions for the TB muscle. In contrast, sEMG integrated activity was higher for the 40% 1-RM and 60% 1-RM (p < 0.01) compared with the 80% 1-RM load. Mean velocity loss at exhaustion and drop in sEMG median frequency were greater in the 40% and 60%-1RM compared with the 80%-1RM condition (p < 0.05). It was concluded that performing a set to exhaustion with maximum intended velocity using a load of 60% 1-RM combines the characteristics of the high average sEMG activity of heavier loads, and the high total integrated sEMG observed at lighter loads.

Players' physical performance in LaLiga across the season: insights for competition continuation after COVID-19.

Due to the COVID-19 outbreak, professional football players competing in LaLiga were confined at home for ~8 weeks and then they were allowed to train to prepare the first competitive match for 4 weeks. As the duration of summer break in the prior four seasons of LaLiga (from 2015-2016 to 2018-2019) was of similar length to the suspension of the championship due to COVID-19 (~12 weeks), we have analysed the running performance of teams competing in LaLiga in these four seasons to anticipate players' physical performance after the resumption of the competition. The analysis includes the average running distance per game for each of the 38 matchdays that compose LaLiga. One-way ANOVA revealed that there was a main effect of the matchday on total running distance per match (p = 0.001), and in the distance covered between 14.0 and 20.9 km/h (p < 0.001), between 21.0 and 23.9 km/h (p < 0.001) and at above 24.0 km/h (p < 0.001). Overall, the post-hoc analysis revealed that the running patterns progressively increased during the first 8-10 matchdays and then reached a plateau which was significantly different to matchday-1 (p < 0.05). This analysis reveals that, in the prior four competitive seasons of LaLiga, players' physical performance was lower at the beginning of the season and the teams needed approximately 8-10 matchdays to reach a steady state running performance. These data suggest that football players will progressively increase their performance across the 11 matchdays remaining to complete LaLiga.

Acute impact of blood flow restriction on strength-endurance performance during the bench press exercise.

The main goal of the present study was to evaluate the acute effects of blood flow restriction (BFR) at 70% of full arterial occlusion pressure on strength-endurance performance during the bench press exercise. The study included 14 strength-trained male subjects (age = 25.6 ± 4.1 years; body mass = 81.7 ± 10.8 kg; bench press 1 repetition maximum (1RM) = 130.0 ± 22.1 kg), experienced in resistance training (3.9 ± 2.4 years). During the experimental sessions in a randomized crossover design, the subjects performed three sets of the bench press at 80% 1RM performed to failure with two different conditions: without BFR (CON); and with BFR (BFR). Friedman's test showed significant differences between BFR and CON conditions for the number of repetitions performed (p < 0.001); for peak bar velocity (p < 0.001) and for mean bar velocity (p < 0.001). The pairwise comparisons showed a significant decrease for peak bar velocity and mean bar velocity in individual Set 1 for BFR when compared to CON conditions (p = 0.01 for both). The two-way repeated measures ANOVA showed a significant main effect for the time under tension (p = 0.02). A post-hoc comparisons for the main effect showed a significant increase in time under tension for BFR when compared to CON (p = 0.02). The results of the presented study indicate that BFR used during strength-endurance exercise generally does not decrease the level of endurance performance, while it causes a drop in bar velocity.

The Influence of Movement Tempo on Acute Neuromuscular, Hormonal, and Mechanical Responses to Resistance Exercise-A Mini Review.

Wilk, M, Tufano, JJ, and Zajac, A. The influence of movement tempo on acute neuromuscular, hormonal, and mechanical responses to resistance exercise-a mini review. J Strength Cond Res 34(8): 2369-2383, 2020-Resistance training studies mainly analyze variables such as the type and order of exercise, intensity, number of sets, number of repetitions, and duration and frequency of rest periods. However, one variable that is often overlooked in resistance training research, as well as in practice, is premeditated movement tempo, which can influence a myriad of mechanical and physiological factors associated with training and adaptation. Specifically, this article provides an overview of the available scientific literature and describes how slower tempos negatively affect the 1-repetition maximum, the possible load to be used, and the number of repetitions performed with a given load, while also increasing the total time under tension, which can mediate acute cardiovascular and hormonal responses. As a result, coaches should consider testing maximal strength and the maximal number of repetitions that can be performed with each movement tempo that is to be used during training. Otherwise, programming resistance training using various movement tempos is more of a trial-and-error approach, rather than being evidence or practice based. Furthermore, practical applications are provided to show how movement tempo can be adjusted for a variety of case study-type scenarios.

In Vitro Investigations of Acetohexamide Binding to Glycated Serum Albumin in the Presence of Fatty Acid.

The interaction of drugs with human serum albumin (HSA) is an important element of therapy. Albumin affects the distribution of the drug substance in the body, as well as its pharmacokinetic and pharmacodynamic properties. On the one hand, inflammation and protein glycation, directly associated with many pathological conditions and old age, can cause structural and functional modification of HSA, causing binding disorders. On the other hand, the widespread availability of various dietary supplements that affect the content of fatty acids in the body means that knowledge of the binding activity of transporting proteins, especially in people with chronic diseases, e.g., diabetes, will achieve satisfactory results of the selected therapy. Therefore, the aim of the present study was to evaluate the effect of a mixture of fatty acids (FA) with different saturated and unsaturated acids on the affinity of acetohexamide (AH), a drug with hypoglycaemic activity for glycated albumin, simulating the state of diabetes in the body. Based on fluorescence studies, we can conclude that the presence of both saturated and unsaturated FA disturbs the binding of AH to glycated albumin. Acetohexamide binds more strongly to defatted albumin than to albumin in the presence of fatty acids. The competitive binding of AH and FA to albumin may influence the concentration of free drug fraction and thus its therapeutic effect.

The effects of resistance training experience on movement characteristics in the bench press exercise.

The main aim of this study was to determine whether the level of experience in strength training has a significant effect on differences in the value of exercise volume determined on time under tension (TUT) and number of repetition (REP) for a specific movement tempo. The study examined 68 men divided into groups of beginners and advanced strength trained athletes. The participants performed 5 sets of bench press (BP) at 70% 1RM using either a REG, MED or SLOW metronome guided cadence. Each set was performed to failure and with 3 min of rest between sets. Significant differences in TUT were found between the groups of beginners and advanced athletes for the slow (SLO) 6/0/4/0 tempo in set 1 (p = 0.01) and set 2 (p = 0.04), and for the regular (REG) 2/0/2/0 tempo in set 5 (p = 0.01). Significant differences were documented for total TUT between the beginners and advanced athletes for the SLO 6/0/4/0 tempo (p = 0.04). The results of ANOVA revealed significant differences in the number of repetitions between groups for the SLO 6/0/4/0 tempo in set 4 (p = 0.04) and set 5 (p = 0.04), and for the REG 2/0/2/0 tempo in set 5 (p = 0.01). The main finding of this study is that strength training experience has a significant effect on training volume, both in terms of TUT and REP at a specific constant movement tempo. Significant differences do not occur for each value of the tempo used.

Impact of Duration of Eccentric Movement in the One-Repetition Maximum Test Result in the Bench Press among Women.

Scientific studies related to resistance training have considered many variables; however, the tempo of movement of particular repetitions is often neglected or not reported in resistance training practice and research. The aim of the study was to determine the effect of different duration of the eccentric (ECC) phase of movement on one-repetition maximum test (1RM) results during the bench press exercise (BP). Twenty-one strength trained females (age = 23.4 ± 2.2 years, body mass = 52.3 ± 6.7 kg), with a minimum one year of strength training experience took part in the study. The experiment was conducted following a randomized crossover design, where each participant completed the 1RM test in the BP with three different duration times of the ECC movement: 2/0/X, 4/0/X, 6/0/X. Concentric (CON) movement was performed with maximal velocity (X). The ANOVA with repeated measures were used to compare the differences between the analyzed variables. The results of the study indicated the maximal load in the 1RM test was significantly higher during the BP with the 2/0/X tempo compared to 6/0/X (p < 0.01) and 4/0/X tempos (p < 0.01). Therefore, the results indicated that the longer the duration of the ECC phase of movement, the greater the decrease in the result of the 1RM test. The 1RM test procedure should include information about the movement tempo used during the test protocol.