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1.
Molecules ; 29(1)2023 Dec 27.
Artigo em Inglês | MEDLINE | ID: mdl-38202756

RESUMO

To improve the adsorption efficiency of pollutants by biochar, preparing graphene-like biochar (GBC) or nitrogen-doped biochar are two commonly used methods. However, the difference in the nitrogen doping (N-doping) effects upon the adsorption of pollutants by pristine biochar (PBC) and GBC, as well as the underlying mechanisms, are still unclear. Take the tetracycline (TC) as an example, the present study analyzed the characteristics of the adsorption of TCs on biochars (PBC, GBC, N-PBC, N-GBC), and significant differences in the effects of N-doping on the adsorption of TCs by PBC and GBC were consistently observed at different solution properties. Specifically, N-doping had varied effects on the adsorption performance of PBC, whereas it uniformly improved the adsorption performance of GBC. To interpret the phenomenon, the N-doping upon the adsorption was revealed by the QSAR model, which indicated that the pore filling (VM) and the interactions between TCs with biochars (Ead-v) were found to be the most important two factors. Furthermore, the density functional theory (DFT) results demonstrated that N-doping slightly affects biochar's chemical reactivity. The van der Waals (vdWs) and electrostatic interactions are the main forces for TCs-biochars interactions. Moreover, N-doping mostly strengthened the electrostatic interactions of TCs-biochars, but the vdWs interactions of most samples remained largely unaffected. Overall, the revealed mechanism of N-doping on TCs adsorption by biochars will enhance our knowledge of antibiotic pollution remediation.


Assuntos
Carvão Vegetal , Poluentes Ambientais , Grafite , Compostos Heterocíclicos , Adsorção , Tetraciclina , Antibacterianos , Nitrogênio , Fatores de Transcrição
2.
Artigo em Inglês | MEDLINE | ID: mdl-39289264

RESUMO

Antibiotics are increasingly found in urban lakes, posing significant ecological risks to lake ecosystems. The impact of sponge city facilities on urban flood control is significant; however, their influence on the exposure characteristics and risks associated with antibiotics in urban inland lakes remains unclear. This study investigated the exposure characteristics and evaluated the ecological risks of 15 antibiotics across seven lakes of Fuzhou (as the target of sponge city) in different seasons, in comparison to non-sponge cities. The results revealed that 12 antibiotics were consistently detectable across all lakes, with concentrations ranging from non-detectable (ND) to 20.61 ng/L, with sulfamethoxazole (SMX) emerging as the predominant contaminant. Most antibiotics exhibited higher concentrations in the dry season, attributed to environmental conditions, biological mechanisms, and their physicochemical properties. SMX, tetracycline (TTC), oxytetracycline (OTC), and ciprofloxacin (CIP) posed moderate to high ecological risks, with risk quotient (RQ) values of 0.46, 0.14, 0.17, and 0.61, respectively, while the remaining antibiotics presented lower ecological risks in both seasons. Notably, the RQ values for TTC, OTC, and CIP were elevated during the dry season, whereas SMX displayed a higher RQ value in the wet season, indicating an increased ecological risk during the dry months. In comparison to non-sponge cities, sponge cities exhibited significantly lower concentrations of nearly all antibiotics, particularly during the wet season (p ≤ 0.05). Moreover, over 85% of the antibiotics in non-sponge cities were classified as high risk, contrasted with only 55% in sponge cities, underscoring the heightened ecological risks associated with non-sponge urban designs. This study provides critical insights for controlling antibiotic pollution in the lakes of Fuzhou and serves as a valuable reference for maintaining aquatic ecosystem health through the implementation of sponge city infrastructure.

3.
J Hazard Mater ; 469: 134056, 2024 May 05.
Artigo em Inglês | MEDLINE | ID: mdl-38522208

RESUMO

The extensive use of antidiabetic drugs (ADDs) and their detection in high concentrations in the environment have been extensively documented. However, the mechanism of ADDs dissipation in aquatic environments is still not well understood. This study thoroughly investigates the dissipation behavior of ADDs and the underlying mechanisms in the aerobic activated sludge system. The results indicate that the removal efficiencies of ADDs range from 3.98% to 100% within 48 h, largely due to the biodegradation process. Additionally, the gene expression of cytochrome P450 (CYP450) is shown to be significantly upregulated in most ADDs-polluted samples (P < 0.05), indicating the vital role of CYP450 enzymes in the biodegradation of ADDs. Enzyme inhibition experiments validated this hypothesis. Moreover, molecular docking and simulation results indicate that a strong correlation between the biodegradation of ADDs and the interactions between ADDs and CYP450 (Ebinding). The differences in dissipation behavior among the tested ADDs are possibly due to their electrophilic characteristics. Overall, this study makes the initial contribution to a more profound comprehension of the crucial function of CYP450 enzymes in the dissipation behavior of ADDs in a typical aquatic environment.


Assuntos
Sistema Enzimático do Citocromo P-450 , Esgotos , Esgotos/química , Simulação de Acoplamento Molecular , Sistema Enzimático do Citocromo P-450/genética , Sistema Enzimático do Citocromo P-450/metabolismo , Biodegradação Ambiental
4.
Sci Total Environ ; 905: 167247, 2023 Dec 20.
Artigo em Inglês | MEDLINE | ID: mdl-37739079

RESUMO

The effects of antibiotics on the proliferation of antibiotic resistant genes (ARGs) in WWTPs have drawn great attention in recent years. The effects of antibiotics on ARGs in the enhanced biological phosphorus removal (EBPR) system and its mechanisms, however, are still not well understood. In this study, EBPR systems were constructed using activated sludge to investigate the effects of ten commonly detected antibiotics in the environment on the proliferation of ARGs and the mechanisms involved. The results showed that the total abundance of ARGs increased to varying degrees with the addition of different antibiotics (0.05 mmol/L), and the top 30 ARGs increased by 271.1 % to 370.0 %. Mobile genetic elements (MGEs), functional modules, and the bacteria community were consistently related to the changes in ARGs. Refractory antibiotics, in particular, have a stronger promoting effect on transduction in the EBPR system. The insertion sequence common region (ISCR) and transposon (Tnp) were identified as crucial factors in the proliferation of ARGs. Moreover, the risk of polyphosphate accumulating organisms (PAOs) carrying ARGs in the presence of antibiotics should not be ignored. Our findings emphasize the potential efficacy of employing strategies that target the reduction of MGEs, regulation of cellular communication, and management of microbial communities to effectively mitigate the risks associated with ARGs.


Assuntos
Antibacterianos , Genes Bacterianos , Antibacterianos/farmacologia , Resistência Microbiana a Medicamentos/genética , Bactérias/genética , Esgotos/microbiologia
5.
Sci Total Environ ; 774: 145571, 2021 Jun 20.
Artigo em Inglês | MEDLINE | ID: mdl-33611003

RESUMO

Many kinds of antibiotics are continuously discharged into wastewater and typically cause a great decrease in sewage treatment performance, whereas mechanisms of differences in the impacts of commonly used antibiotics on phosphate removal are still elusive. Thus, an enhanced biological phosphorus removal (EBPR) system, as an effective method of phosphate removal, was developed, and its performance in the treatment of artificial wastewater containing antibiotics at short- (8 h) and long-term (15 days) exposure was investigated. The results show that phosphorus removal was consistently inhibited by the addition of antibiotics with a significant difference (P < 0.05). To interpret the phenomena, mechanistic equations were developed, and the results indicate that for short-term tests, the difference was mainly caused by the suppression of polyhydroxyalkanoate (PHA) degradation and the activity of polyphosphate kinase (PPK), resulting in the different inhibition of the soluble orthophosphorus (SOP) uptake process. For long-term tests, the difference in SOP uptake was principally caused by the inhibition of PHA degradation and the activity of PPK, whereas the difference in SOP release resulted from the inhibition of activities of exopolyphosphatase (PPX) and adenylate kinase (ADK). Moreover, micro-mechanisms of such inhibition were identified from molecular docking and electrostatic potential.


Assuntos
Fósforo , Eliminação de Resíduos Líquidos , Antibacterianos/toxicidade , Reatores Biológicos , Simulação de Acoplamento Molecular , Esgotos
6.
J Hazard Mater ; 406: 124291, 2021 03 15.
Artigo em Inglês | MEDLINE | ID: mdl-33153784

RESUMO

Waste residues have been prepared as biochar (BC) adsorbents to remove sulfonamides (SAs) at low cost, but the mechanisms of the differences in the SA adsorption performance of different BCs are not clear. Thus, the adsorption characteristics of two SAs (sulfadiazine and sulfathiazole) on three BCs derived from waste residues (sewage sludge (SB), pig manure (PB), and rice straw (RB)) were investigated. The results showed that the adsorption mechanism was chemisorption and RB was the preferred BC under the different tested conditions (pH, Ca2+, and humic acid), followed by PB and SB. To interpret the phenomena, FTIR, XRD, and XPS analyses were performed and results indicated that SB had the lowest C content, and there was a very significant difference in the concentrations of the two O functional groups (CË­O and C‒O) for PB and RB (P < 0.01). Density functional theory calculations revealed that the mechanisms of SA adsorption onto BCs were mainly through π-π electron donor acceptor interactions and H bonds. There was no significant difference in the π interactions between the SAs-BC containing C‒O (BC(OH)) and the SAs-BC containing CË­O (BC(CË­O)), whereas the H bond strength of SAs-BC(OH) was much stronger than that of SAs-BC(CË­O).


Assuntos
Carvão Vegetal , Sulfonamidas , Adsorção , Animais , Esterco , Suínos
7.
Sci Total Environ ; 726: 138516, 2020 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-32305759

RESUMO

Antibiotic resistance genes (ARGs) have been widely detected around the world and are generally viewed as emerging pollutants with environmental persistence. The proliferation of ARGs can be easily promoted by antibiotics. However, the dynamics of ARGs in the environment are still unable to be quantified using a single parameter, which is vital to evaluating the ability of ARGs to spread by antibiotics and effectively controlling ARGs. A new parameter, termed the relative area ratio of sample to control (ΔAR), was developed based on the quantitative features determined by ARG-time curves in soils contaminated with sulfonamides (SAs) and verified by quantitative structure-activity relationships (QSARs) models. The results showed that ΔAR can not only be used to accurately quantify the characteristics of SAs resistance genes (Suls) over time but also be applied to reveal the relationships between the proliferation of Suls and important factors (i.e., concentrations and chemical structures). Moreover, the ΔAR-based QSARs model indicated that bioavailability and the frequency of conjugative transfer, rather than the ability of induced mutations in bacteria, tend to be key processes of the characteristics of the proliferation of Suls. Therefore, ΔAR is a useful parameter to perform environmental risk assessments of ARG proliferation in the environment.


Assuntos
Antibacterianos/farmacologia , Sulfonamidas , Proliferação de Células/efeitos dos fármacos , Resistência Microbiana a Medicamentos/efeitos dos fármacos , Genes Bacterianos/efeitos dos fármacos
8.
J Agric Food Chem ; 68(47): 13594-13607, 2020 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-33172257

RESUMO

Sulfonamides (SAs) are widespread in soils, and their dissipation behavior is important for their fate, risk assessment, and pollution control. In this work, we investigated the dissipation behavior of different SAs in a soil under aerobic condition, focusing on revealing the relationship between overall dissipation (without sterilization and in dark) and individual abiotic (sorption, hydrolysis)/biotic (with sterilization and in dark) factors and taxonomy/function of microbiomes. The results showed that dissipation of all SAs in the soil followed the pseudo-first-order kinetic model with dissipation time at 50% removal (DT50) of 2.16-15.27 days. Based on, experimentally, abiotic/biotic processes and, theoretically, partial least-squares modeling, a relationship between overall dissipation and individual abiotic/biotic factors was developed with microbial degradation as the dominant contributor. Metagenomic analysis showed that taxonomic genera like Bradyrhizobium/Sphingomonas/Methyloferula and functions like CAZy family GT51/GH23/GT2, eggNOG category S, KEGG pathway ko02024/ko02010, and KEGG ortholog K01999/K03088 are putatively involved in SA microbial degradation in soil. Spearman correlation suggests abundant genera being multifunctional. This study provides some new insights into SA dissipation and can be applied to other antibiotics/soils in the future.


Assuntos
Microbiota , Poluentes do Solo , Cinética , Metagenômica , Solo , Poluentes do Solo/análise , Sulfonamidas
9.
PLoS One ; 14(12): e0226541, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31856252

RESUMO

Organisms are frequently exposed to mixtures of heavy metals because of their persistence in the environment. The mixture toxicity of heavy metals should therefore be evaluated to perform a rational environmental risk assessment for organisms. In this study, we determined the inhibition toxicity of five heavy metals (Cu2+, Co2+, Zn2+, Fe3+ and Cr3+) and their binary mixtures to Photobacterium phosphoreum (P. phosphoreum). We obtained the following results: (1) the order of individual toxicity was Zn2+>Cu2+>Co2+>Cr3+>Fe3+, and (2) different combined effects (additive, synergistic and antagonistic) were observed in the binary mixtures of heavy metals, with toxicity unit (TU) values ranging from 0.15 to 3.50. To predict the mixture toxicity of heavy metals, we derived the ion characteristic parameters of heavy metal mixtures and explored the ion-characteristic-based quantitative structure-activity relationship (QSAR) model (R2 = 0.750, Q2 = 0.649). The developed QSAR model indicated that the mixture toxicity of heavy metals is related to the change in ionization potential ((ΔIP)mix), the first hydrolysis constant (log(KOH)mix) and the formation constant value ([Formula: see text]).


Assuntos
Metais Pesados/química , Metais Pesados/toxicidade , Photobacterium/efeitos dos fármacos , Relação Quantitativa Estrutura-Atividade , Relação Dose-Resposta a Droga , Interações Medicamentosas , Modelos Teóricos
10.
J Vasc Access ; 20(6): 636-645, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30919741

RESUMO

PURPOSE: To evaluate the feasibility and accuracy of intracavitary electrocardiogram for verifying tip position of peripherally inserted central catheters in cancer patients during follow-up period. METHODS: From March 2015 to October 2015, 126 patients involved in eight hospitals who underwent peripherally inserted central catheter placement received intracavitary electrocardiogram and chest X-ray to verify position of the catheter tip during follow-up period. Their intracavitary electrocardiogram was compared with surface electrocardiogram to judge catheter tip landing zone in one of three different anatomical zones. The amplitude of intracavitary electrocardiogram P wave and the ratio of intracavitary electrocardiogram P wave/surface electrocardiogram P wave were measured and showed correlation with catheter tip position confirmed by chest X-ray. Based on chest X-ray principle, all the cases were assigned into three intracavitary electrocardiogram groups to explore the optimal cut-off values for intracavitary electrocardiogram P wave and intracavitary electrocardiogram P wave/surface electrocardiogram P wave by analyzing the receiver operating characteristic. RESULTS: No technique-related complications or adverse events occurred in this study. The matching rate between intracavitary electrocardiogram and chest X-ray method was 93.7%. The optimal cut-off values for intracavitary electrocardiogram P wave were set from 3.15 to 3.75 mV, and intracavitary electrocardiogram P wave/surface electrocardiogram P wave from 1.65 to 3.25. CONCLUSIONS: It is demonstrated in this retrospective multicenter study that the intracavitary electrocardiogram method for verifying tip position of peripherally inserted central catheter during follow-up period is feasible and accurate in all adult patients with cancer.


Assuntos
Antineoplásicos/administração & dosagem , Cateterismo Venoso Central/instrumentação , Cateterismo Periférico/instrumentação , Cateteres Venosos Centrais , Eletrocardiografia , Neoplasias/tratamento farmacológico , Administração Intravenosa , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Cateterismo Venoso Central/efeitos adversos , Cateterismo Periférico/efeitos adversos , China , Desenho de Equipamento , Estudos de Viabilidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Reprodutibilidade dos Testes , Estudos Retrospectivos , Adulto Jovem
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