Assuntos
Hipersensibilidade Alimentar , Prunus persica , Alérgenos , Antígenos de Plantas , Frutas , Humanos , Proteínas de PlantasRESUMO
BACKGROUND: The role of specific IgE (sIgE) against Der p 1 and Der p 2 in Chinese patients with house dust mite (HDM) allergy has not yet been well investigated. METHODS: One hundred patients were enrolled, based on sensitization and doctor-diagnosed allergy to HDM. Questionnaires were administered to document demographic and clinical characteristics. Serum IgE reactivity to Dermatophagoides pteronyssinus (Dp) extract, Der p 1, Der p 2 and Der p 10 was measured by ImmunoCAP. RESULTS: Almost all patients were sensitized to Der p 1 (95%) and Der p 2 (93%), with both allergens together being largely responsible for the total anti-HDM IgE response. No evidence for a significant role of Der p 10 was found. Overall, IgE responses to HDM and its 2 major allergens were higher in children than in adults in this cross-sectional study. With increasing age, IgE responses to Der p 2 become more important. A positive correlation was observed between the reaction of sIgE against Dp, Der p 1 and Der p 2 and the number of organs (including the eyes, nose, lungs and skin) that were affected in patients. CONCLUSIONS: In China, Der p 1 and Der p 2 are the dominant allergens in patients with HDM allergy. The relative importance of Der p 1 and Der p 2 changes with age, in favor of Der p 2. Overall, sIgE titers were positively associated with the number of organs affected.
Assuntos
Alérgenos/imunologia , Antígenos de Dermatophagoides/imunologia , Proteínas de Artrópodes/imunologia , Cisteína Endopeptidases/imunologia , Hipersensibilidade/imunologia , Imunoglobulina E/imunologia , Adolescente , Adulto , Fatores Etários , Animais , Criança , Pré-Escolar , Feminino , Humanos , Hipersensibilidade/sangue , Hipersensibilidade/epidemiologia , Imunoglobulina E/sangue , Masculino , Pessoa de Meia-Idade , Prevalência , Fatores de Risco , Testes Cutâneos , Adulto JovemAssuntos
Linfócitos T CD4-Positivos/metabolismo , Relógios Circadianos/genética , Ritmo Circadiano/genética , Fatores de Transcrição Forkhead/genética , Intestinos/imunologia , Transcrição Gênica/genética , Adulto , Animais , Linfócitos T CD4-Positivos/imunologia , Relógios Circadianos/imunologia , Ritmo Circadiano/imunologia , Feminino , Hipersensibilidade Alimentar/sangue , Hipersensibilidade Alimentar/genética , Hipersensibilidade Alimentar/imunologia , Fatores de Transcrição Forkhead/imunologia , Humanos , Imunoglobulina E/sangue , Subunidade alfa de Receptor de Interleucina-2/genética , Subunidade alfa de Receptor de Interleucina-2/imunologia , Interleucina-4/sangue , Mucosa Intestinal/metabolismo , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Linfócitos T Reguladores/imunologia , Transcrição Gênica/imunologiaAssuntos
Alérgenos/imunologia , Antígenos de Plantas/imunologia , Proteínas de Transporte/imunologia , Hipersensibilidade Alimentar/imunologia , Pólen/imunologia , Prunus/imunologia , Alérgenos/metabolismo , Antígenos de Plantas/metabolismo , Artemisia/imunologia , Proteínas de Transporte/metabolismo , China , Hipersensibilidade Alimentar/metabolismo , Humanos , Imunoglobulina E/imunologia , Imunoglobulina E/metabolismo , Ligação Proteica/imunologia , Prunus/efeitos adversosRESUMO
OBJECTIVE: To determine Th1/Th2 cytokines and chemokines in patients with allergic diseases and its clinic significance. METHODS: Serum levels of IFN-gamma, IL-4, IL-5, IL-13, Eotaxin, RANTES and LTB4 were determined from peripheral blood of 64 allergic patients and 21 healthy controls with ELISA. RESULTS: IL-4, IL-5, IL-13 and Eotaxin, LTB4 were increased significantly in serum of allergic patients compared with those of controls (P<0.05). There were no significant differences in serum levels of IFN-gamma and RANTES between patients and controls (P>0.05). Serum levels of IL-4, IL-5, IL-13 and LTB4 were correlated with each other (P<0.01). Eotaxin, RANTES and IFN-gamma levels were also significantly correlated with each other (P<0.05). LTB4 was correlated with Eotaxin as well (P<0.01). CONCLUSION: A wide range of cytokines and chemokines is involved in allergic diseases,which may play their roles in a complex interactive manner.