[Knobloch syndrome: a case report].

A 5-year-old girl came to the Tianjin Medical University Eye Hospital in May 2021 because of her poor eyesight after birth. The physical examination showed that she had high myopia, esotropia, horizontal tremor, and high myopia retinopathy of both eyes. After inquiring about her medical history, we found that the baby's occipital cystic mass swelled after birth, and CT examination showed that the occipital skull plate defect with meningocele, but without treatment, at present, the occipital mass had subsided by itself. Considering the eye manifestations and skull changes of the child, it may be conformed to Knobloch syndrome, after the detection of V4 by full exon gene, it was found that the child had the compound heterozygous variation of pathogenic gene COL18A1, and Knobloch syndrome was definite, Knobloch syndrome is a rare autosomal recessive hereditary disease with typical features of high myopia, retinal detachment and occipital encephalocele. At present, there is no clear treatment plan, and gene therapy may be an effective treatment for Knobloch syndrome in the future.

[Effects of acupuncture on blood pressure, SOD,LPO and five kinds of trace elements to stenosis of renal artery caused hypertension in rats].

Changes of blood pressure, superoxide dismutase (SOD), lipid peroxidation (LPO) and concentration of five kinds of trace elements including Cu, Zn, Fe, Ca, Mg were observed before or after acupuncture treatment in the stenosis of renal artery caused hypertension in rats [correction of mice]. It was demonstrated that acupuncture in the points of Zusanli, Neiguan, Sanyinjiao and Yongquan in mice could reduce the blood pressure significantly and influence the concentrations of SOD, LPO and five kinds of trace elements in the stenosis of renal artery caused hypertension in mice. The possible mechanisms of acupuncture in reducing the blood pressure and influencing the changes of SOD, LPO and five kinds of trace elements were also discussed.