Quantum Fluctuation of the Quantum Geometric Tensor and Its Manifestation as Intrinsic Hall Signatures in Time-Reversal Invariant Systems.

In time-reversal invariant systems, all charge Hall effects predicted so far are extrinsic effects due to the dependence on the relaxation time. We explore intrinsic Hall signatures by studying the quantum noise spectrum of the Hall current in time-reversal invariant systems, and discover intrinsic thermal Hall noises in both linear and nonlinear regimes. As the band geometric characteristics, quantum geometric tensor and Berry curvature play critical roles in various Hall effects; so do their quantum fluctuations. It is found that the thermal Hall noise in linear order of the electric field is purely intrinsic, and the second-order thermal Hall noise has both intrinsic and extrinsic contributions. In particular, the intrinsic part of the second-order thermal Hall noise is a manifestation of the quantum fluctuation of the quantum geometric tensor, which widely exists as long as Berry curvature is nonzero. These intrinsic thermal Hall noises provide direct measurable means to band geometric information, including Berry curvature related quantities and quantum fluctuation of quantum geometric tensor.

Polluted air evokes nostalgic reverie: A preliminary investigation in China.

Air pollution is related to a variety of psychological distresses (e.g., insecurity), and such distresses may in turn evoke nostalgia as a coping response. Three studies with complementary methodologies were conducted to examine the potential relationship between air pollution and nostalgia in China. Drawing on panel data from 2011 to 2018 covering 31 provincial regions, Study 1 indicated that air pollution positively predicted nostalgia. Study 2 found that air-polluted days were correlated with elevated nostalgia during the 212-day study period. Study 3 further demonstrated that compared with the control condition, participants in the experimentally induced air pollution condition reported more nostalgia, and insecurity mediated this effect. Collectively, our findings provide preliminary evidence that air pollution is positively associated with nostalgia. The implications and limitations of this work were discussed.

Pure spin current and phonon thermoelectric transport in a triangulene-based molecular junction.

The experimental synthesis and characterization of enigmatic triangulene were reported for the first time recently. Based on this enigmatic molecule, we proposed a triangulene-based molecular junction and presented first principles calculations to investigate the electron and phonon thermoelectric transport properties. Numerical results show that the spin polarized electric transport properties of the triangulene-based molecular junction can be adjusted effectively by bias voltage and gate voltage. Through varying the gate voltage applied on the triangulene molecule, the system can exhibit a perfect spin filter effect. When a temperature gradient is applied between the two leads, spin up current and spin down current flow along opposite directions in the system simultaneously. Thus pure spin current can be obtained on a large scale by changing the temperature, temperature gradient, and gate voltage. When the phonon vibration effect is considered in thermal transport, the figure of merit is suppressed distinctively especially when the temperature is within the 10 K < T < 100 K range. More importantly, a large spin figure of merit can be achieved accompanied by a small charge figure of merit by adjusting the temperature, gate voltage and chemical potential in a wide range, which indicates a favorable application prospect of the triangulene-based molecular junction as a spin calorigenic device.

Photoinduced valley-polarized current of layered MoS2 by electric tuning.

A photoinduced current of a layered MoS2-based transistor is studied from first-principles. Under the illumination of circular polarized light, a valley-polarized current is generated, which can be tuned by the gate voltage. For monolayer MoS2, the valley-polarized spin-up (down) electron current at K (K') points is induced by the right (left) circular polarized light. The valley polarization is found to reach +1.0 (-1.0) for the valley current that carried such a K (K') index. For bilayer MoS2, the spin-up (down) current can be induced at both K and K' valleys by the right (left) circular light. In contrast to monolayer MoS2, the photoinduced valley polarization shows asymmetric behavior upon reversal of the gate voltage. Our results show that the valley polarization of the photoinduced current can be modulated by the circular polarized light and the gate voltage. All the results can be well understood using a simple kp model.

Trend of histone deacetylase inhibitors in cancer therapy: isoform selectivity or multitargeted strategy.

Pharmacological inhibition of histone deacetylases (HDACs) has been successfully applied in the treatment of a wide range of disorders, including Parkinson's disease, infection, cardiac diseases, inflammation, and especially cancer. HDAC inhibitors (HDACIs) have been proved to be effective antitumor agents by various stages of investigation. At present, there are two opposite focuses of HDACI design in the cancer therapy, highly selective inhibitor strategy and dual- or multitargeted inhibitors. The former method, which is supposed to elucidate the function of individual HDAC and provide candidate inhibitors with fewer side effects, has been widely accepted by the inhibitor developer. The latter approach, though less practiced, has promising potential for the antitumor therapy based on HDACIs. Effective HDACIs, some of which are in clinic anticancer research, have been developed by both methods. In order to gain insight into HDACI design, the strategies and achievements of the two diverse methods are reviewed.

Discovery of N-(3-((7H-purin-6-yl)thio)-4-hydroxynaphthalen-1-yl)-sulfonamide derivatives as novel protein kinase and angiogenesis inhibitors for the treatment of cancer: Synthesis and biological evaluation. Part III.

A novel series of N-(3-((7H-purin-6-yl)thio)-4-hydroxynaphthalen-1-yl)-sulfonamides were designed and synthesized. Biological characterization revealed that several compounds exerted enhanced anti-proliferative activity against human umbilical vein endothelial cells (HUVECs) and several cancer cell lines and high specific protein kinase and angiogenesis inhibitory activities. Compared with our previously synthesized compounds, the substitution of sulfonamide structure for amide fragment played an essential role for the advance of inhibitory activities. In addition, the replacement of 1H-1,2,4-triazole ring by 7H-purine did not result in obvious decrease of inhibition efficacy, indicating that the sulfonamide structure contributes even more to the inhibition efficacy than the 1H-1,2,4-triazole ring. Among these compounds, compound 9n demonstrated comparable in vitro antiangiogenic activities to pazopanib in both HUVEC tube formation assay and the rat thoracic aorta rings (TARs) test. Meanwhile, compound 9n was identified to inhibit Akt1 (IC50=1.73 µM) and Abl tyrosine kinase (IC50=1.53 µM) effectively.

The relationship between mindfulness, anxiety and depression during the COVID-19 pandemic: A meta-analysis of correlational studies.

Background: The emergence of the COVID-19 pandemic has created an environment in which numerous determinants of poor mental health are intensified. Lockdown, re-lockdown, and media coverage of the spread of the virus, have the potential to contribute to increased levels of anxiety and depression. Mindfulness may act as a buffer against COVID-19-related depressive and anxiety disorders. Methods: We conducted a systematic review and meta-analysis by searching PubMed, PsycINFO, Web of Science, and Google Scholar for any study published between January 2020 and March 2022. In this study, Comprehensive Meta-Analysis Version 3.3 software was applied to evaluate the effect size by random effect model. In addition, the heterogeneity analysis was evaluated using indicators Q and I2 indicators. Three methods were used to test for publication bias: funnel plot, Classic Fail-safe N, and Egger's linear regression. According to the features of the included articles, subgroup analysis was utilized for the moderator analysis of this study. Results: The analysis finally included 12 articles (16 samples, N = 10,940) and obtained 26 independent effect sizes. In accordance with the meta-analysis, in the random effect model, the correlation between mindfulness and anxiety was -0.330 (p < 0.001), and the correlation between mindfulness and depression was -0.353 (p < 0.001), which supported the effect of mindfulness on anxiety and depression. In the meta-analysis of the correlation between mindfulness and anxiety, study region had an essential moderating effect (p < 0.001). The Sample type did not produce a significant moderating effect (p = 0.190). The mode of action of mindfulness was a significant moderator (p = 0.038). In the meta-analysis of the linkage between mindfulness and depression, regional differences had a significant moderating effect (p < 0.001). The sample type had no discernible moderating impact (p = 0.213). The mode of action of mindfulness was a significant moderator (p = 0.003). Conclusion: Our meta-analysis indicated that there was an essential correlation between public mindfulness and mental health. Our systematic review added evidence supporting the beneficial nature of mindfulness. A cascading development of beneficial traits that improve mental health may start with mindfulness.

Consequences of scarcity: the impact of perceived scarcity on executive functioning and its neural basis.

Introduction: Previous studies have found a causal relationship between scarcity and the adverse impact it has on executive functioning. However, few studies have directly examined perceived scarcity, and cognitive flexibility (the third component of executive functions) has rarely been included. Methods: Using a 2 (group: scarcity group vs. control group) × 2 (trial type: repeat trial vs. switch trial) mixed design, this study directly explored perceived scarcity's impact on cognitive flexibility and revealed its neural basis in the switching tasks. Seventy college students participated in this study through open recruitment in China. A priming task was used to induce perceived scarcity, thus exploring the impact of perceived scarcity on participants' performance in switching tasks and enabling the analysis of the neural activity of the brain, combined with electroencephalograph (EEG) technology. Results: In terms of behavioral outcomes, perceived scarcity led to poorer performance and a greater switching cost of reaction time in the switching tasks. Regarding neural activity, perceived scarcity led to an increase in the amplitude of P3 differential wave (repeat trials minus switch trials) in the parietal cortex during the target-locked epochs in the switching tasks. Discussion: Perceived scarcity can lead to changes in the neural activity of the brain regions related to executive functioning, resulting in a temporary decrease in cognitive flexibility. It may lead to individuals unable to adapt well to the changing environment, unable to quickly devote themselves to new tasks, and reduce work and learning efficiency in daily life.

Precise Conformational Control Yielding Highly Potent and Exceptionally Selective BRD4 Degraders with Strong Antitumor Activity.

Starting from a nonselective bromodomain and extraterminal (BET) inhibitor and a cereblon ligand, we have used precise conformational control for the development of two potent and highly selective BRD4 degraders, BD-7148 and BD-9136. These compounds induce rapid degradation of BRD4 protein in cells at concentrations as low as 1 nM and demonstrate ≥1000-fold degradation selectivity over BRD2 or BRD3 protein. Proteomic analysis of >5700 proteins confirmed their highly selective BRD4 degradation. A single dose of BD-9136 selectively and effectively depletes BRD4 protein in tumor tissues for >48 h. BD-9136 effectively inhibits tumor growth without adverse effects on mice and is more efficacious than the corresponding pan BET inhibitor. This study suggests selective degradation of BRD4 as a strategy for the treatment of human cancers and demonstrates a strategy for the design of highly selective PROTAC degraders.

Rashba Effect and Spin-Dependent Excitonic Properties in Chiral Two-Dimensional/Three-Dimensional Composite Perovskite Films.

Among various chiral semiconductor materials, chiral two-dimensional (2D)/three-dimensional (3D) composite perovskites (CPs) offer the benefits of strong interface asymmetry and energy transfer between 2D and 3D phases, making the chiral CPs promising for spintronic devices. Therefore, understanding their spintronic properties will be greatly important for expanding their relevant applications. In this work, we synthesized one pair of chiral 2D/3D CP films. Their Rashba effect and spin relaxation process have been investigated by polarization-dependent femtosecond transient absorption spectroscopy. Interestingly, under left- and right-handed circularly polarized light (CPL) excitation, a two-photon emission intensity difference is observed in chiral 2D/3D CP films at 298 K. This work sheds light on the spin-dependent excitonic characteristics of chiral 2D/3D CPs and confirms the feasibility of their application in near-infrared CPL detection.

The Influence of Trait Emotion and Spatial Distance on Risky Choice Under the Framework of Gain and Loss.

In the time of the COVID-19 pandemic, people are often faced with uncertain risky choice. Risky choice will be affected by different descriptions of the event's gain or loss framework, this phenomenon is known as the framing effect. With the continuous expansion and in-depth study of frame effects in the field of risky choice, researchers have found that the are quite different in different situations. People have different interpretations of the same event at different psychological distances, and will also be affected by their own emotions. Therefore, the current study examines the common influence of task frame, spatial distance, and trait emotion on risky choice through two studies. Study 1 used a 2 (framework: gain vs. loss) × 2 (trait sentiment: high vs. low) inter-subject design, and the dependent variable is the choice of the rescue plan for the classic "Asian disease" problem. The results revealed that trait anger did not predict individuals' risky choice preferences, and high trait anxiety led individuals to be more risk-averse. The framing effect exists in risky choice, and individuals prefer risk seeking in the loss frame. Study 2 used a 2 (spatial distance: distant vs. proximal) × 2 (framework: gain vs. loss) × 2 (trait sentiment: high vs. low) three-factor inter-subject design in which the dependent variable is the choice of rescue plan. The results indicate that the framing effect also exists in risky choice, and individuals prefer risk seeking in a loss frame. High trait anxiety lead individuals to be more risk-averse, while trait anger has no significant predictive effect on risk preference. Distant spatial distance lead individuals to increase their preference for risk-seeking under the gain frame, which leads to the disappearance of the framing effect. In conclusion, trait anxiety and spatial distance have a certain degree of influence on risky choice under the framework of gain and loss.

Impacts of Stress Response and Negative Emotion on Mental Health of College Students During the COVID-19 Outbreak.

Object: In this study, we aimed to explore the influences of stress responses and negative emotion on mental health of college students during the initial COVID-19 outbreak in China. Methods: A nationally representative sample of 1,351 college students, aged 18-23 years, took part in an online survey during the COVID-19 outbreak. The ANOVA, correlation coefficients, structural equation modeling (path analysis), and other statistical analysis methods were used for data analysis. Results: (1) The Chinese college students' epidemic panic and cognitive evaluation were found to be moderate (3.73 ± 0.74, 3.76 ± 0.62), while their defensive response was higher (4.61 ± 0.55). Their mental health during the COVID-19 outbreak was found to be good (3.75 ± 0.76). (2) The quality of their mental health was significantly and negatively associated with epidemic panic, and the quality of their mental health was significantly and positively associated with defensive response. (3) The quality of their mental health was significantly and negatively associated with negative emotion. (4) College students' epidemic panic and defensive response to the COVID-19 had a directly predictive effect on their mental health. Conclusion: College students' negative emotion played a partial mediating role in the relationship between epidemic panic and mental health. College students' negative emotion played a complete mediating role in the relationship between cognitive appraisal and mental health.

Impacts of Stress and Risk Perception on Mental Health of College Students During the COVID-19 Pandemic: The Mediating Role of Coping Efficacy.

OBJECT: In this study, we aimed to explore the influences of pandemic stress, risk perception, and coping efficacy on the mental health of Chinese college students during the COVID-19 pandemic. METHODS: A nationally representative sample of Chinese college students (N = 3,381, M age = 20.85, SD age = 1.31) took part in an online survey during the COVID-19 pandemic. Correlation coefficients, structural equation modeling, and other statistical analysis methods were used for data analysis. RESULTS: (1) The Chinese college students' pandemic stress and perceived pandemic risk were found to be moderate (3.51 ± 0.83, 3.45 ± 0.94), whereas their perceived infection risk was lower (2.10 ± 0.67). Their mental health during the COVID-19 pandemic was found to be good (3.80 ± 0.73). (2) The quality of their mental health was significantly and negatively associated with pandemic stress, perceived pandemic risk, and perceived infection risk. The level of their mental health was significantly and positively associated with coping efficacy, and their coping efficacy was significantly and negatively associated with pandemic stress, perceived pandemic risk, and perceived infection risk. CONCLUSION: Coping efficacy played a partial mediating role in the relationship between pandemic stress and mental health, coping efficacy played a partial mediating role in the relationship between perceived infection risk and mental health, and coping efficacy played a complete mediating role in the relationship between perceived pandemic risk and mental health. Our findings show the importance of fostering college students' coping efficacy to improve their mental health during the COVID-19 pandemic.

Novel Two-Dimensional Layered MoSi2Z4 (Z = P, As): New Promising Optoelectronic Materials.

Very recently, two new two-dimensional (2D) layered semi-conducting materials MoSi2N4 and WSi2N4 were successfully synthesized in experiments, and a large family of these two 2D materials, namely MA2Z4, was also predicted theoretically (Science, 369, 670 (2020)). Motivated by this exciting family, in this work, we systematically investigate the mechanical, electronic and optical properties of monolayer and bilayer MoSi2P4 and MoSi2As4 by using the first-principles calculation method. Numerical results indicate that both monolayer and bilayer MoSi2Z4 (Z = P, As) present good structural stability, isotropic mechanical parameters, moderate bandgap, favorable carrier mobilities, remarkable optical absorption, superior photon responsivity and external quantum efficiency. Especially, due to the wave-functions of band edges dominated by d orbital of the middle-layer Mo atoms are screened effectively, the bandgap and optical absorption hardly depend on the number of layers, providing an added convenience in the experimental fabrication of few-layer MoSi2Z4-based electronic and optoelectronic devices. We also build a monolayer MoSi2Z4-based 2D optoelectronic device, and quantitatively evaluate the photocurrent as a function of energy and polarization angle of the incident light. Our investigation verifies the excellent performance of a few-layer MoSi2Z4 and expands their potential application in nanoscale electronic and optoelectronic devices.

Electrophysiological Measurement of Emotion and Somatic State Affecting Ambiguity Decision: Evidences From SCRs, ERPs, and HR.

Twenty-three years ago, the Somatic Marker Hypothesis (SMH) proposed by Damasio was introduced to explain the role of emotion in decision-making, and provided a unique neuroanatomical framework for decision-making and its influence by emotion. The core idea of the SMH is that decision-making is a process that is affected by somatic state signals, including those that express themselves in emotion and feeling. In order to verify the SMH, the Iowa Gambling Task (IGT) was originally designed by Bechara et al. and the skin conductance responses (SCRs) was recorded during the IGT. The initial confirmatory results showed that normal subjects would generate anticipatory SCRs when they received reward or punishment, but patients of the VMPFC lesion entirely failed to generate anticipatory SCRs prior to their selection of a card. With the further development of the SMH-related researches, other electrophysiological methods of measuring somatic state was gradually used to test the SMH, including event-related potentials (ERPs), and heart rate (HR). In this mini review article, we summarize the extant electrophysiological research on the SMH and decision-making under ambiguity, propose an integrative perspective for employing different electrophysiological measurement methods, and indicate the application of electrophysiological measurement based on the SMH in daily social decision-making.

Bridging Ecological Rationality, Embodied Emotion, and Neuroeconomics: Insights From the Somatic Marker Hypothesis.

The somatic marker hypothesis (SMH) has been utilized to demonstrate the role of emotion and somatic state in decision-making under uncertainty over the past two decades. Despite some debate, the SMH has provided not only a neurobiological framework for understanding emotion and decision-making but also a good empirical support for ecological rationality and embodied emotion. Unlike the traditional maximizing rationality and bounded satisficing rationality, the ecological rationality stresses that emotions should be brought to the decision-making process. The embodied emotion furthermore emphasizes that emotions are embodied in the body and the brain. On the other hand, behavioral decision-making has spawned many new interdisciplines, including neuroeconomics. In this case, the SMH could act as a bridge to translate the ecological rationality and the embodied emotion into emerging neuroeconomics. Thus, this mini-review article aims to propose an integrated framework for introducing ecological rationality and embodied emotion into the field of neuroeconomics by virtue of insights from the SMH.

Emotional responses and coping strategies in nurses and nursing students during Covid-19 outbreak: A comparative study.

The coronavirus disease (COVID-19) outbreak in December has seen more than 76,000 cases in China, causing more than 3,000 medical staff infections. As the disease is highly contagious, can be fatal in severe cases, and there are no specific medicines, it poses a huge threat to the life and health of nurses, leading to a severe impact on their emotional responses and coping strategies. Therefore, this study will investigate nurses' emotional responses and coping styles, and conduct a comparative study with nursing college students. This study was conducted through the online survey 'questionnaire star' from February 1st to February 20th, 2020 in Anhui Province, using the snowball sampling method to invite subjects. The results found that women showed more severe anxiety and fear than men. Participants from cities exhibited these symptoms more than participants from rural areas, however rural participants experienced more sadness than urban participants. The nearer a COVID-19 zone is to the participants, the stronger the anxiety and anger. The COVID-19 outbreak has placed immense pressure on hospitals and those nurses at the frontline are more seriously affected. Hospitals should focus on providing psychological support to nurses and training in coping strategies.

Maxims nudge equitable or efficient choices in a Trade-Off Game.

The core problem in the distribution dilemma is the trade-off between equity and efficiency. With the development of socio-economic conditions, the optimal decision changes between equitable and efficient options. The methods for nudging decision-makers to make optimal decisions without changing the event are extremely important. This study used two laboratory behavior experiments to explore the impact of maxim information on the trade-off between equity and efficiency. The study explores whether stake levels and division schemes affect the nudging effect of the maxim in a Trade-Off Game (TOG). We found that participants were affected by maxim information in decision-making scenarios, and participants showed different equity preferences as the maxim information changed, without relevance of the stake level. Additionally, the nudging effect of the maxim only exists under the condition that the distributor's interests is not affected.

Psychopathy and Decision-Making: Antisocial Factor Associated With Risky Decision-Making in Offenders.

Psychopathy is a personality development disorder increasing the risk of antisocial behavior. Studies on the relationship between psychopathy and decision-making have received limited attention and the result of studies is mixed. A present study examines whether or not the different factors of psychopathy are related to decision-making under risk and ambiguity in offenders and how they are related. Also, the study investigates whether general intelligence is associated with decision-making or moderates the relationship between psychopathy and decision-making. The results showed that only antisocial factor of psychopathy significantly correlates with Game of Dice Task (GDT) risky selections, but there no general relation between psychopathy and Iowa Gambling Task (IGT) performance. Lastly, general intelligence neither is related to decision-making under risk and ambiguity nor moderates the relationship between decision-making and psychopathy. The study results show that antisocial factor of psychopathy was associated with decision-making under risk rather than ambiguity. Our results also suggest that the antisocial factor of psychopathy was more related to executive dysfunction in offenders.

Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER).

The estrogen receptor (ER) is a validated target for the treatment of estrogen receptor-positive (ER+) breast cancer. Here, we describe the design, synthesis, and extensive structure-activity relationship (SAR) studies of small-molecule ERα degraders based on the proteolysis targeting chimeras (PROTAC) concept. Our efforts have resulted in the discovery of highly potent and effective PROTAC ER degraders, as exemplified by ERD-308 (32). ERD-308 achieves DC50 (concentration causing 50% of protein degradation) values of 0.17 and 0.43 nM in MCF-7 and T47D ER+ breast cancer cell lines, respectively, and induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines. Significantly, ERD-308 induces more complete ER degradation than fulvestrant, the only approved selective ER degrader (SERD), and is more effective in inhibition of cell proliferation than fulvestrant in MCF-7 cells. Further optimization of ERD-308 may lead to a new therapy for advanced ER+ breast cancer.