Detalhe da pesquisa
1.
Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition.
Bioorg Med Chem Lett
; 43: 128048, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33887438
2.
Discovery of DS68702229 as a Potent, Orally Available NAMPT (Nicotinamide Phosphoribosyltransferase) Activator.
Chem Pharm Bull (Tokyo)
; 69(11): 1110-1122, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34719594
3.
Attenuation of pulmonary fibrosis in type I collagen-targeted reporter mice with ALK-5 inhibitors.
Pulm Pharmacol Ther
; 54: 31-38, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30448291
4.
A novel inhibitor of I-kappaB kinase beta ameliorates experimental arthritis through downregulation of proinflammatory cytokines in arthritic joints.
Biol Pharm Bull
; 37(1): 87-95, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24389485
5.
A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid.
Bioorg Med Chem
; 21(1): 42-61, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23218775
6.
Improvement of pulmonary function by oral treatment with a VLA-4 antagonist in a mouse asthmatic model.
J Pharmacol Sci
; 121(2): 172-5, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23419271
7.
Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo.
J Immunol
; 187(1): 181-9, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21606247
8.
Identification of trans-4-[1-[[7-fluoro-2-(1-methyl-3-indolyl)-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid as a potent, orally active VLA-4 antagonist.
Bioorg Med Chem
; 20(3): 1201-12, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22261021
9.
Feasibility of an Ultrasound-Based Method for Measuring Talar Displacement during the Anterior Drawer Stress Test Using a Telos Device: A Preliminary Study.
Int J Environ Res Public Health
; 19(4)2022 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35206561
10.
Fission yeast Swi1-Swi3 complex facilitates DNA binding of Mrc1.
J Biol Chem
; 285(51): 39609-22, 2010 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-20924116
11.
Discovery of imidazo[1,2-b]pyridazines as IKKß inhibitors. Part 3: exploration of effective compounds in arthritis models.
Bioorg Med Chem Lett
; 21(15): 4550-5, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21705219
12.
Discovery of imidazo[1,2-b]pyridazines as IKKß inhibitors. Part 2: improvement of potency in vitro and in vivo.
Bioorg Med Chem Lett
; 21(3): 904-8, 2011 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21232950
13.
A novel and potent VLA-4 antagonist based on trans-4-substituted cyclohexanecarboxylic acid.
Bioorg Med Chem
; 17(3): 1232-43, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19124247
14.
The novel gene mus7(+) is involved in the repair of replication-associated DNA damage in fission yeast.
DNA Repair (Amst)
; 6(6): 770-80, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17307401
15.
Identification of 4-[1-[3-chloro-4-[N'-(5-fluoro-2-methylphenyl)ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]benzoic acid as a potent, orally active VLA-4 antagonist.
Bioorg Med Chem
; 16(23): 9991-10000, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18952443
16.
Hsk1 kinase and Cdc45 regulate replication stress-induced checkpoint responses in fission yeast.
Cell Cycle
; 9(23): 4627-37, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21099360
17.
Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist.
J Med Chem
; 52(24): 7974-92, 2009 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-19891440
18.
Synthesis and biological evaluation of benzoic acid derivatives as potent, orally active VLA-4 antagonists.
Bioorg Med Chem
; 15(4): 1679-93, 2007 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17194595
19.
Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists.
Bioorg Med Chem
; 14(8): 2725-46, 2006 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16377201
20.
4-(Pyrrolidinyl)methoxybenzoic acid derivatives as a potent, orally active VLA-4 antagonist.
Chem Pharm Bull (Tokyo)
; 54(11): 1515-29, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17077548