Enhanced four-wave mixing in P T-symmetric optomechanical systems.

We investigate the enhanced four-wave mixing (FWM) process in a parity-time (P T)-symmetric optomechanical system, where an active cavity is coupled to a passive cavity supporting a mechanical mode. The passive cavity is optically driven by a strong control field and a weak probe field, and the mechanical mode is excited by a weak coherent driving field. By tuning the coupling strength between the two cavities with balanced gain and loss, we find that the FWM intensity can be significantly enhanced near the exceptional points (EPs) at low control power, which is about 12 orders of magnitude higher than that of the single-cavity case. Due to the interference effect induced by the optical and mechanical driving field, it is shown that the FWM intensity can be further enhanced or suppressed by tuning the amplitude and phase of the mechanical driving field. Moreover, the dependence of the FWM intensity on the frequency and power of the control field is also discussed. Our work provides a route to enhance the four-wave mixing process in a flexible way.

Phase-controlled amplification and slow light in a hybrid optomechanical system.

We theoretically investigate the transmission and group delay of a probe field incident on a hybrid optomechanical system, which consists of a mechanical resonator simultaneously coupled to an optical cavity and a two-level system (qubit). The cavity field is driven by a strong red-detuned control field, and a weak coherent mechanical driving field is applied to the mechanical resonator. With the assistance of additional mechanical driving field, it is shown that double optomechanically induced transparency can be switched into absorption due to destructive interference or amplification because of constructive interference, which depends on the phase difference of the applied fields. We study in detail how to control the probe transmission by tuning the parameters of the optical and mechanical driving fields. Furthermore, we find that the group delay of the transmitted probe field can be prolonged by the tuning the amplitude and phase of the mechanical driving field.

Tunable slow and fast light in parity-time-symmetric optomechanical systems with phonon pump.

We study the response of parity-time (PT)-symmetric optomechanical systems with tunable gain and loss to the weak probe field in the presence of a strong control field and a coherent phonon pump. We show that the probe transmission can exceed unity at low control power due to the optical gain of the cavity and it can be further enhanced or suppressed by tuning the amplitude and phase of the phonon pump. Furthermore, the phase dispersion of the transmitted probe field is modified by controlling the applied fields, which allows one to tune the group delay of the probe field. Based on this optomechianical system, we can realize a tunable switch between slow and fast light effect by adjusting the gain-to-loss ratio, power of the control field as well as the amplitude and phase of the phonon pump. Our work provides a platform to control the light propagation in a more flexible way.

Simultaneous determination of methylephedrine and noscapine in human plasma by liquid chromatography-tandem mass spectrometry.

A selective and sensitive method has been developed and validated for simultaneous quantification of methylephedrine and noscapine in human plasma. Analytes were extracted from human plasma samples by liquid-liquid extraction, separated on a Diamonsil C18 column and detected by tandem mass spectrometer with an atmospheric pressure chemical ionization (APCI) interface. Diphenhydramine was used as the internal standard (I.S.). The method was found to be precise and accurate within the linear range 0.1-100 ng/ml for each analyte. The intra- and inter-day relative standard deviations (R.S.D.s) were below 5.2% for methylephedrine and 6.7% for noscapine. The inter-day relative error (RE) as determined from quality control samples (QCs) was less than 3.0% for each analyte. The assay was successfully employed in a pharmacokinetic study after an oral administration of a multicomponent formulation containing 20 mg DL-methylephedrine hydrochloride, 16 mg noscapine, 300 mg paracetamol and 1mg of chlorpheniramine maleate.

Influence of omeprazole on pharmacokinetics of domperidone given as free base and maleate salt in healthy Chinese patients.

AIM: To investigate the influence of omeprazole on the pharmacokinetics of domperidone given as free base and maleate salt. METHODS: An open, randomized, 2-period crossover study with a washout period of 7 d was conducted in 10 healthy Chinese, male patients. In each study period, the patients were administered a single oral dose of 10 mg domperidone as free base or maleate salt on d 1, 20 mg omeprazole twice daily on d 2 and 3, and once on d 4. A single dose of 10 mg domperidone as free base or maleate salt was taken at 4 h after administration of omeprazole on d 4. Plasma samples were collected on d 1 and 4 after the administration of domperidone, and the plasma concentrations of domperidone were determined by a sensitive liquid chromatography-tandem mass spectrometry method. RESULTS: For free-base domperidone, pretreatment with omeprazole resulted in a 16% decrease in maximum concentration (C(max)), compared with administration alone (P<0.05). However, for maleate salt, with the exception of an increase in t(1/2), no pharmacokinetic parameters were significantly changed. When the free base and maleate salt were administered alone, no differences were found in any parameters between the 2 formulations. In contrast, when they were administered in the presence of omeprazole, the C(max) of domperidone given as free base was lower (25.9%) than that given as maleate salt (P<0.05). CONCLUSION: Pretreatment of omeprazole does not affect the absorption of domperidone maleate, but leads to a moderately decreased rate of absorption of the free base.