Detalhe da pesquisa
1.
Ingestion of single guide RNAs induces gene overexpression and extends lifespan in Caenorhabditis elegans via CRISPR activation.
J Biol Chem
; 298(7): 102085, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35636511
2.
Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes.
Proc Natl Acad Sci U S A
; 111(40): 14512-7, 2014 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25246545
3.
Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide.
Nat Chem Biol
; 9(11): 693-700, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24077178
4.
Rosmarinic Acid Improves Cognitive Abilities and Glucose Metabolism in Aged C57Bl/6N Mice While Disrupting Lipid Profile in Young Adults in a Sex-Dependent Fashion.
Nutrients
; 15(15)2023 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37571303
5.
A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging.
Nat Commun
; 14(1): 8142, 2023 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38065964
6.
Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress.
Cell Metab
; 6(4): 280-93, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17908557
7.
Inhibition of alanine aminotransferase in silico and in vivo promotes mitochondrial metabolism to impair malignant growth.
J Biol Chem
; 286(25): 22323-30, 2011 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-21540181
8.
L-Theanine extends lifespan of adult Caenorhabditis elegans.
Eur J Nutr
; 51(6): 765-8, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22422488
9.
Antioxidants prevent health-promoting effects of physical exercise in humans.
Proc Natl Acad Sci U S A
; 106(21): 8665-70, 2009 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-19433800
10.
The sex-specific metabolic signature of C57BL/6NRj mice during aging.
Sci Rep
; 12(1): 21050, 2022 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36473898
11.
Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan.
Nat Commun
; 13(1): 107, 2022 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35013237
12.
Dual role of the mitochondrial protein frataxin in astrocytic tumors.
Lab Invest
; 91(12): 1766-76, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21863062
13.
Low-dose lithium uptake promotes longevity in humans and metazoans.
Eur J Nutr
; 50(5): 387-9, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21301855
14.
Green tea catechins EGCG and ECG enhance the fitness and lifespan of Caenorhabditis elegans by complex I inhibition.
Aging (Albany NY)
; 13(19): 22629-22648, 2021 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34607977
15.
Opposing effects of dietary sugar and saturated fat on cardiovascular risk factors and glucose metabolism in mitochondrially impaired mice.
Eur J Nutr
; 49(7): 417-27, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20221766
16.
Redox-mediated regulation of aging and healthspan by an evolutionarily conserved transcription factor HLH-2/Tcf3/E2A.
Redox Biol
; 32: 101448, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32203922
17.
Author Correction: Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease.
Nat Commun
; 11(1): 3706, 2020 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32694526
18.
Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease.
Nat Commun
; 11(1): 2080, 2020 04 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32350271
19.
Small-molecule targeting of the mitochondrial compartment with an endogenously cleaved reversible tag.
Chembiochem
; 10(10): 1689-96, 2009 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-19492396
20.
Maternally Inherited Differences within Mitochondrial Complex I Control Murine Healthspan.
Genes (Basel)
; 10(7)2019 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31337008