RESUMO
Repeated renal transplant calcinosis is a rare event. We report a young woman in whom repeated calcinosis was observed in two consecutive renal transplants. Persistent secondary hyperparathyoidism and hyperphosphatemia due to impaired renal function were assumed as the pathogenic factors for calcinosis. Sub-total parathyroidectomy performed shortly after the third transplantation and good function of the renal graft have prevented calcinosis in the third graft for more than five years.
Assuntos
Calcinose/etiologia , Nefropatias/etiologia , Transplante de Rim/efeitos adversos , Adulto , Biópsia , Calcinose/sangue , Calcinose/diagnóstico por imagem , Calcinose/patologia , Feminino , Seguimentos , Humanos , Hiperparatireoidismo Secundário/complicações , Hiperparatireoidismo Secundário/cirurgia , Rim/patologia , Nefropatias/sangue , Nefropatias/diagnóstico por imagem , Nefropatias/patologia , Paratireoidectomia , Fosfatos/sangue , Recidiva , Reoperação , Fatores de Tempo , Tomografia Computadorizada por Raios XRESUMO
BACKGROUND: About 50% of the world population is infected with Helicobacter pylori. The association of peptic ulcer disease with Helicobacter pylori is well documented. Therefore eradication is obligatory. However, the high costs of multidrug therapy, the resistance of Helicobacter pylori to antibiotics as well as the sometimes present drug intolerance are limiting factors. METHODS: The inhibitory effect of 3% hydrogen peroxide, 8.4% sodium bicarbonate, 2% ascorbic acid, citric acid in combination with sodium citrate, 7% and 14% citric acid solutions, respectively, on nine Helicobacter pylori strains were tested in vitro. RESULTS: Citric acid showed a potent inhibitory activity on growth of Helicobacter pylori strains in vitro. This was observed not only when citric acid was applied alone but also if citric acid was given together with low concentration of sodium citrate. Two percent ascorbic acid inhibited three, sodium bicarbonate two and hydrogen peroxide one of the nine tested Helicobacter pylori strains, respectively. CONCLUSIONS: Citric acid is a cheap substance present in many fruits and produced by food industry, and it demonstrated powerful inhibitory effect on the growth of Helicobacter pylori strains. On the basis of our findings citric acid should be further evaluated for the eradication of Helicobacter pylori.
Assuntos
Ácido Cítrico/farmacologia , Helicobacter pylori/efeitos dos fármacos , Helicobacter pylori/fisiologia , Antibacterianos/administração & dosagem , Apoptose/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Relação Dose-Resposta a Droga , Helicobacter pylori/citologiaRESUMO
We report on a Mycobacterium marinum infection in a diabetic woman 8 years after undergoing a combined pancreas-kidney transplantation. This is, to our knowledge, the first case report on an isolated skin infection with atypical mycobacteria after simultaneous pancreas-kidney transplantation. A genetic probe categorization revealed an infection with M. marinum. Skin tuberculosis caused by M. marinum is an uncommon complication in kidney or pancreas-kidney transplant recipients, hence the diagnosis can be delayed.