Biocompatible Silica-Coated Europium-Doped CsPbBr3 Nanoparticles with Luminescence in Water for Zebrafish Bioimaging.

Cesium lead halide (CsPbX3, X = Br, Cl, and I) nanocrystals (NCs) are widely concerned and applied in many fields due to the excellent photoelectric performance. However, the toxicity of Pb and the loss of luminescence in water limit its application in vivo. A stable perovskite nanomaterial with good bioimaging properties is developed by incorporating europium (Eu) in CsPbX3 NCs followed with the surface coating of silica (SiO2) shell (CsPbX3:Eu@SiO2). Through the surface coating of SiO2, the luminescence stability of CsPbBr3 in water is improved and the leakage of Pb2+ is significantly reduced. In particular, Eu doping inhibits the photoluminescence quantum yield reduction of CsPbBr3 caused by SiO2 coating, and further reduces the release of Pb2+. CsPbBr3:Eu@SiO2 nanoparticles (NPs) show efficient luminescence in water and good biocompatibility to achieve cell imaging. More importantly, CsPb(ClBr)3:Eu@SiO2 NPs are obtained by adjusting the halogen components, and green light and blue light are realized in zebrafish imaging, showing good imaging effect and biosafety. The work provides a strategy for advanced perovskite nanomaterials toward biological practical application.

Novel Cerium-Based Sulfide Nano-Photocatalyst for Highly Efficient CO2 Reduction.

To address the environmental crisis caused by excessive emissions of CO2 , the development of effective photocatalysts for the conversion of CO2 into chemicals has emerged as one of the most promising strategies. Herein, beyond those well-studied materials, a rare-earth sulfide-based nanocrystal NaCeS2 is fabricated and investigated for efficient and selective conversion of CO2 into CO, where the role of Ce ions is crucial. Firstly, the hybridization of Ce 4f and Ce 5d orbitals contributes to the photoresponsive band structure of NaCeS2 . Secondly, due to the charge rearrangement supplied by the incompletely filled 4f orbitals of Ce ions, NaCeS2 exhibits excellent charge separation efficiency and CO2 adsorption affinity, reducing the energy barrier for the conversion from CO2 to CO. Moreover, a NaCeS2 -MoS2 heterostructure is also designed to further boost the electron transfer from the Mo site to the Ce site, which results in an improvement of the catalytic reduction yield from 7.24 to 23.42 µmol g-1 within 9 h (both better than TiO2 controls). This work offers a platform for the development of rare-earth-based photocatalysts for CO2 conversion.

Fast Li-ion Conductor of Li3HoBr6 for Stable All-Solid-State Lithium-Sulfur Battery.

Rare-earth (RE) solid-state halide electrolytes have been extensively studied recently in the field of lithium (Li) ion all-solid-state batteries (ASSBs) due to their excellent electrochemical performances. Herein, a new RE-based solid halide electrolyte Li3HoBr6 (LHB) has been synthesized and exhibits high Li ion conductivity up to mS cm-1 at room temperature. Theoretical calculations have identified four different Li ion migration pathways, in which the out-of-plane pathways are much more favorable than the direct in-plane pathways. In addition, LHB has a wider electrochemical window in comparison to a sulfide solid electrolyte and good deformability. The LHB-based Li-sulfur ASSB assembled by cold pressing can exhibit good cycling stability with high Coulombic efficiency, which shows that LHB has potential application in ASSBs.

A Library of Rare Earth Oxide Ultrathin Nanowires with Polymer-Like Behaviors.

Ultrathin nanowires (NWs) have always attracted the attention of researchers due to their unique properties, but their facile synthesis is still a great challenge. Herein we developed a general method for the synthesis of rare earth (RE) oxide ultrathin NWs at atmospheric pressure and low temperature (50 °C). The formation mechanism of ultrathin NWs lies in two aspects: thermodynamic advantage of one dimensional (1D) growth at low temperature, and supplement of effective monomers. As an extension, fifteen kinds of RE oxide ultrathin NWs were synthesized through this strategy, and they all exhibited polymer-like behaviors. Meanwhile, the high viscosity, organic gel, wet- and electro-spinning of Ce-Mo-O NWs were studied in detail, demonstrating the similarity of ultrathin inorganic NWs to polymers. In addition, the Ce-Mo-O ultrathin NWs were used as photocatalysts for toluene oxidation and showed excellent performance with toluene conversion ratio of 83.8 %, suggesting their potential application in organic photocatalysis.

What factors predict physicians' utilization behavior of contrast-enhanced ultrasound? Evidence from the integration of the Theory of Planned Behavior and Technology Acceptance Model using a structural equation modeling approach.

BACKGROUND: The promotion of early diagnosis is undoubtedly effective in reducing the burden of disease. Contrast-enhanced ultrasound (CEUS) is a diagnostic technology for liver cancer, but its implementation faces some challenges. Understanding the influencing factors of CEUS utilization is crucial for its successful implementation. However, such research is rare. The aims of this study were to investigate the status of CEUS utilization and its predictors in China. METHODS: Through multistage random sampling, a cross-sectional study design was conducted among physicians in charge of direct use of CEUS working at liver disease-related departments of sampled health institutions. To access the potential influencing factors of physicians' CEUS utilization, a structured questionnaire was developed based on the theoretical model, which was developed by integration of the Theory of Planned Behavior (TPB) and Technology Acceptance Model (TAM). Structural equation modeling was used to verify the proposed hypotheses, and analyze the relationship and mechanism between the factors. RESULTS: A total of 309 physicians were enrolled. The mean score of utilization behavior was 2.04 (SD = 1.07), and 37.22% above the mean. The favorable fitting results demonstrated that the integration of TAM and TPB was an acceptable model. SEM results also identified physicians' intentions to use CEUS was directly associated with utilization behavior (ß = 0.287, P < 0.001). Attitude (ß = 0.272, P < 0.001), subjective norm (ß = 0.172, P = 0.013), perceived behavioral control (ß = 0.491, P < 0.001) and perceived usefulness (ß = 0.108, P = 0.027) significantly influenced physicians' intentions. Besides, subjective norm (ß = 0.065, P = 0.021), perceived behavioral control (ß = 0.141, P = 0.003), and perceived ease of use (ß = 0.022, P = 0.033) indirectly affected physicians' CEUS utilization. CONCLUSIONS: The findings provide a reference for understanding the factors associated with physicians' utilization of CEUS. Additionally, the proposed measures such as building innovative and incentive environment, providing high quality and adequate training, etc., will help promote the utilization of CEUS, thereby increasing the detection rate of liver cancer, and improving the survival rate and the quality of life for liver cancer patients.

Rare-earth-containing perovskite nanomaterials: design, synthesis, properties and applications.

As star material, perovskites have been widely used in the fields of optics, photovoltaics, electronics, magnetics, catalysis, sensing, etc. However, some inherent shortcomings, such as low efficiency (power conversion efficiency, external quantum efficiency, etc.) and poor stability (against water, oxygen, ultraviolet light, etc.), limit their practical applications. Downsizing the materials into nanostructures and incorporating rare earth (RE) ions are effective means to improve their properties and broaden their applications. This review will systematically summarize the key points in the design, synthesis, property improvements and application expansion of RE-containing (including both RE-based and RE-doped) halide and oxide perovskite nanomaterials (PNMs). The critical factors of incorporating RE elements into different perovskite structures and the rational design of functional materials will be discussed in detail. The advantages and disadvantages of different synthesis methods for PNMs will be reviewed. This paper will also summarize some practical experiences in selecting suitable RE elements and designing multi-functional materials according to the mechanisms and principles of REs promoting the properties of perovskites. At the end of this review, we will provide an outlook on the opportunities and challenges of RE-containing PNMs in various fields.

Strain-Negligible Eu2+ Doping Enabled Color-Tunable Harsh Condition-Resistant Perovskite Nanocrystals for Superior Light-Emitting Diodes.

Cesium lead halide (CsPbX3, X = Br, Cl, I) perovskite nanocrystals (NCs) possess tunable band gaps across the entire visible spectral range and are promising for various optoelectronic device applications. However, poor performance in adverse conditions limits their further development in practical optoelectronics. Herein, highly stable perovskite NCs are developed by doping europium(II) (Eu2+) into the B-site of CsPbBr3 with negligible lattice distortion/strain. Eu2+-doped CsPbBr3 NCs exhibit tunable green-to-cyan emissions, high photoluminescence quantum yield, and good resistance to harsh conditions, including ultraviolet irradiation, erosion of moisture, and corrosion of polar solvent molecules. In particular, the thermal stability of CsPbBr3 NCs after Eu2+ doping is greatly enhanced under continuous heating in air, while exhibiting the emissions of Eu2+. Furthermore, a Eu2+-doped CsPbBr3 NC-based cyan light-emitting diode is fabricated, which exhibits narrow exciton emission driven under different current densities. This work would open the avenue to develop the rational lanthanide ion doping strategy for further advancing perovskite nanomaterials toward practical applications.

Knowledge sharing of health technology among clinicians in integrated care system: The role of social networks.

Promoting clinicians' knowledge sharing of appropriate health technology within the integrated care system (ICS) is of great vitality in bridging the technological gap between member institutions. However, the role of social networks in knowledge sharing of health technology is still largely unknown. To address this issue, the study aims to clarify the influence of clinicians' social networks on knowledge sharing of health technology within the ICS. A questionnaire survey was conducted among the clinicians in the Alliance of Liver Disease Specialists in Fujian Province, China. Social network analysis was conducted using NetDraw and UCINET, and the quadratic assignment procedure (QAP) multiple regression was used to analyze the influencing factors of knowledge sharing of health technology. The results showed that the ICS played an insufficient role in promoting overall knowledge sharing, especially inter-institutional knowledge sharing. Trust, emotional support, material support, and cognitive proximity positively influenced knowledge sharing of health technology, while the frequency of interaction and relationship importance had a negative impact on it. The finding extended the research scope of social network theory to the field of healthcare and will bridge the evidence gap in the influence of the clinicians' social networks on their knowledge sharing within the ICS, providing new ideas to boost knowledge sharing and diffusion of appropriate health technology.

In-depth study on the structures and properties of rare-earth-containing perovskite materials.

Rare-earth-containing perovskite (RECP) materials have been extensively studied in various fields for their outstanding optical, electrical, magnetic and catalytic properties. In order to understand the clear relationship between structures and functions of RECP materials, the high-level and effective characterization technologies and analytic methods are absolutely necessary. Normally, diversiform measurement methods should be used simultaneously to analyze RECP materials clearly from different aspects, such as the phases, structures, morphologies, compositions, properties and performances. Therefore, this review will introduce the features and advantages of different analytic technologies and discuss their significances for the research on RECP materials. We hope that this review will provide valuable suggestions for researchers to promote the further research and development of RECP functional materials in the future.

Dynamics of Health Technology Diffusion in the Integrated Care System (DHTDICS): A Development and Validation Study in China.

BACKGROUND: Limited diffusion of health technology has greatly halted the improvement of resource integration and healthcare outcomes. The importance of understanding the dynamics of health technology diffusion is increasingly highlighted. However, the dynamic mechanism of health technology diffusion in the context of the integrated care system (ICS) remained largely unknown. PURPOSE: To develop and validate the scale on Dynamics of Health Technology Diffusion in Integrated Care System (DHTDICS) for providing an instrument to investigate the health technology diffusion in the ICS in China, by taking the Des-gamma-Carboxy Prothrombin (DCP) test as an example. METHODS: Based on previous classical theories such as the theory of planned behavior (TPB), technology acceptance model (TAM), and technology-organization-environment framework (TOE), the scale with 34 items was initially developed. It was tested in a cross-sectional questionnaire survey including 246 participants from February to August 2019 in China. Cronbach's alpha, corrected item-total correlation, and factor loadings were used to assess reliability. Exploratory factor analysis and confirmatory factor analysis were applied to evaluate the validity by assessing factor structures and correlations. RESULTS: Reliability analysis revealed excellent internal consistency. Acceptable validity was confirmed through tests of convergent validity and discriminant validity. Regarding the domains that DHTDICS contributes, the results highlighted 4 domains: personal beliefs (including dimensions of attitudes, subjective norms and perceived behavioral control), technical drivers (including dimensions of ease of use and price rationality), organizational readiness (including dimensions of organizational culture, technology absorptive willingness and technology sharing willingness), and external environment (dimension of industry competition pressure). CONCLUSION: The findings confirmed the reliability and validity of the scale on DHTDICS. The scale will be not only a scientific tool in determining the dynamics of health technology diffusion in the ICS, but also a helpful reference for developing future interventions to promote health technology diffusion.

Predictors of physicians' intentions to use clinical practice guidelines on antimicrobial in tertiary general hospitals of China: a structural equation modeling approach.

BACKGROUND: With inappropriate use of antimicrobials becoming a great public health concern globally, the issue of applying clinical practice guidelines (CPGs) to regulate the rational use of antimicrobials has attracted increasing attention. Taking tertiary general hospitals in China for example, this study aimed to identify factors to investigate the comprehensive influencing mechanism for physicians' intention to use CPGs on antimicrobials. METHODS: Based on the integration of Theory of Planned Behavior (TPB), Technology Acceptance Model (TAM), and Technology-Organization-Environment framework (TOE), a questionnaire survey was conducted covering potential determinants of affecting physicians' intentions to use CPGs on antimicrobials at the individual level (attitude, subjective norms and perceived risk), technical level (relative advantage and ease of use), and organizational level (top management support and organizational implementation). Data were collected from 644 physicians in tertiary general hospitals in eastern, central and western China, which were obtained by multi-stage random sampling. The structural equation modeling (SEM) was used to link three-level factors with physicians' behavioral intentions. RESULTS: The majority of the participants (94.57%) showed a positive tendency toward intention to use CPGs on antimicrobials. The reliability and validity analysis showed the questionnaire developed from the theoretical model was acceptable. SEM results revealed physicians' intentions to use CPGs on antimicrobials was associated with attitude (ß = 0.166, p < 0.05), subjective norms (ß = 0.244, p < 0.05), perceived risk (ß = - 0.113, p < 0.05), relative advantage (ß = 0.307, p < 0.01), top management support (ß = 0.200, p < 0.05) and organizational implementation (ß = 0.176, p < 0.05). Besides, subjective norms, perceived risk, relative advantage, ease of use, and top management support showed their mediating effects from large to small on the intentions, which were 0.215, 0.140, 0.103, 0.088, - 0.020, respectively. CONCLUSIONS: This study revealed the significance of multifaceted factors to enhance the intention to use CPGs on antimicrobials. These findings will not only contribute to the development of targeted intervention strategies on promoting the use of CPGs on antimicrobials, but also provide insights for future studies about physicians' adoption behaviors on certain health services or products.

Gram-Scale Synthesis of Nanosized Li3 HoBr6 Solid Electrolyte for All-Solid-State Li-Se Battery.

Rare earth (RE) based halide solid electrolytes (HEs) are recently considered as research hotspots in the field of all-solid-state batteries (ASSBs). The RE-based HEs possess high ionic conductivity, credible deformability, and good stability, which can bring excellent electrochemical performances for ASSBs. However, the conventional synthetic methods of RE HEs are a mechanochemical process and co-melting strategy, both approaches require expensive raw materials and sophisticated equipment. Therefore, a lot of research work is required to promote the preparation methods for these promising SSEs in ASSBs. Thus, a vacuum evaporation-assisted synthesis method is developed for the massive synthesis of HEs. The as-prepared Li3 HoBr6 (LHB) has a high lithium-ion conductivity close to the mS cm-1 level and the LHB-based Li-Se ASSBs can be assembled by cold pressing. Theoretical calculations have revealed that the Li migrations are highly preferred in Li3 HoBr6 owing to the low energy cost and high tolerance of stable structure. The tetrahedral and octahedral pathways are responsible for Li migrations in short and long ranges, respectively. The results show that the LHB-based Li-Se battery has good stability and rate performance, indicating that LHB has potential application in the field of ASSBs.

Multimodal Luminescent Yb3+ /Er3+ /Bi3+ -Doped Perovskite Single Crystals for X-ray Detection and Anti-Counterfeiting.

Anti-counterfeiting techniques have become a global topic since they is correlated to the information and data safety, in which multimodal luminescence is one of the most desirable candidates for practical applications. However, it is a long-standing challenge to actualize robust multimodal luminescence with high thermal stability and humid resistance. Conventionally, the multimodal luminescence is usually achieved by the combination of upconversion and downshifting luminescence, which only responds to the electromagnetic waves in a limited range. Herein, the Yb3+ /Er3+ /Bi3+ co-doped Cs2 Ag0.6 Na0.4 InCl6 perovskite material is reported as an efficient multimodal luminescence material. Beyond the excitation of ultraviolet light and near-infrared laser (980 nm), this work extends multimodal luminescence to the excitation of X-ray. Besides the flexible excitation sources, this material also shows the exceptional luminescence performance, in which the X-ray detection limit reaches the level of nGy s-1 , indicating a great potential for further application as a colorless pigment in the anti-counterfeiting field. More importantly, the obtained double perovskite features high stability against both humidity and temperature up to 400 °C. This integrated multifunctional luminescent material provides a new directional solution for the development of multifunctional optical materials and devices.

[Performance of an Aerobic Granular Reactor Treating Biogas Slurry from Pig Farm].

This research investigated the performance of an aerobic granular reactor treating biogas slurry from pig farm. Results indicated that the granular structure of aerobic sludge was not affected by the high pollution concentrationsin the biogas slurry. Although a low removal rate of phosphate was found in this study (about 16%±2%), organic matter and ammonia nitrogen showed stable removal and transformation in the granular system, and the effluent concentrations of those components were (267±81)mg·L-1 and(62±12)mg·L-1, respectively. In addition, the removal rate of sulfamethazine and tetracycline was 98%±2% and 65%±16%, respectively. During the process biogas slurry treatment, bacterial communities in the aerobic granular reactor remained stable, and Comamonadaceae was the dominant bacteria (relative abundance ofapproximately 16.66%).

Characteristics and performance of aerobic algae-bacteria granular consortia in a photo-sequencing batch reactor.

The characteristics and performance of algae-bacteria granular consortia which cultivated with aerobic granules and targeted algae (Chlorella and Scenedesmus), and the essential difference between granular consortia and aerobic granules were investigated in this experiment. The result indicated that algae-bacteria granular consortia could be successfully developed, and the algae present in the granular consortia were mainly Chlorella and Scenedesmus. Although the change of chlorophyll composition revealed the occurrence of light limitation for algal growth, the granular consortia could maintain stable granular structure, and even showed better settling property than aerobic granules. Total nitrogen and phosphate in the algal-bacterial granular system showed better removal efficiencies (50.2% and 35.7%) than those in the aerobic granular system (32.8% and 25.6%) within one cycle (6 h). The biodiesel yield of aerobic granules could be significantly improved by algal coupled process, yet methyl linolenate and methyl palmitoleate were the dominant composition of biodiesel obtained from granular consortia and aerobic granules, respectively. Meanwhile, the difference of dominant bacterial communities in the both granules was found at the order level and family level, and alpha diversity indexes revealed the granular consortia had a higher microbial diversity.