Detalhe da pesquisa
1.
Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by 19F NMR and Cryo-EM.
J Am Chem Soc
; 145(15): 8583-8592, 2023 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37023263
2.
Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.
Proc Natl Acad Sci U S A
; 115(29): E6863-E6870, 2018 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29967165
3.
Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti-malaria Activity in Humanized Mice.
Angew Chem Int Ed Engl
; 60(17): 9279-9283, 2021 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33433953
4.
Protocol for analysis of intracellular conversion of artezomib molecules into new proteasome inhibitors in Plasmodium falciparum parasites.
STAR Protoc
; 5(1): 102896, 2024 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38363687
5.
Exploitation of Proximity-Mediated Effects in Drug Discovery: An Update of Recent Research Highlights in Perturbing Pathogenic Proteins and Correlated Issues.
J Med Chem
; 66(15): 10122-10149, 2023 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37489834
6.
Discovery of Highly Selective Inhibitors of the Human Constitutive Proteasome ß5c Chymotryptic Subunit.
J Med Chem
; 66(2): 1172-1185, 2023 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36608337
7.
Structure of the human UBR5 E3 ubiquitin ligase.
Structure
; 31(5): 541-552.e4, 2023 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37040767
8.
Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors.
Nat Commun
; 14(1): 8302, 2023 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38097652
9.
Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome InhibitorsâPart II.
J Med Chem
; 66(2): 1484-1508, 2023 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36630286
10.
Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance.
Cell Chem Biol
; 30(5): 457-469.e11, 2023 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37148884
11.
Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome.
Cell Chem Biol
; 30(5): 470-485.e6, 2023 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36963402
12.
Design, synthesis and biological evaluation of novel acrylamide analogues as inhibitors of BCR-ABL kinase.
Bioorg Med Chem Lett
; 22(16): 5279-82, 2012 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22789429
13.
Design, synthesis and antitumor activities of novel bis-aryl ureas derivatives as Raf kinase inhibitors.
Bioorg Med Chem
; 20(14): 4323-9, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22721924
14.
Design, Synthesis, and Optimization of Macrocyclic Peptides as Species-Selective Antimalaria Proteasome Inhibitors.
J Med Chem
; 65(13): 9350-9375, 2022 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35727231
15.
Discovery of N-((3S,4S)-4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl-1H-pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity.
J Med Chem
; 64(16): 12163-12180, 2021 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34375113
16.
Macrocyclic Peptides that Selectively Inhibit the Mycobacterium tuberculosis Proteasome.
J Med Chem
; 64(9): 6262-6272, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33949190
17.
Structure-Activity Relationships of Noncovalent Immunoproteasome ß5i-Selective Dipeptides.
J Med Chem
; 63(21): 13103-13123, 2020 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33095579
18.
Discovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors.
Eur J Med Chem
; 180: 72-85, 2019 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31301565
19.
Phenotypic Screening-Based Identification of 3,4-Disubstituted Piperidine Derivatives as Macrophage M2 Polarization Modulators: An Opportunity for Treating Multiple Sclerosis.
J Med Chem
; 62(7): 3268-3285, 2019 04 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30856328
20.
Selective Phenylimidazole-Based Inhibitors of the Mycobacterium tuberculosis Proteasome.
J Med Chem
; 62(20): 9246-9253, 2019 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31560200