Not to follow because of distrust: perceived trust modulates the gaze cueing effect.

In social life, people spontaneously form stable trustworthiness impressions from faces. However, the precise role of extracting trustworthiness information remains unclear. This study aims to elucidate whether discerning facial trustworthiness influences social interactions. Specifically, it explores the gaze cueing effect (GCE), wherein individuals exhibit quicker responses to targets appearing in the direction of gaze compared to other locations. Given conflicting perspectives in existing literature regarding the potential modulation of trustworthiness on the GCE, two plausible hypotheses are proposed to explain divergent result patterns. The reflexive hypothesis posits that the GCE operates automatically. In contrast, the flexible hypothesis underscores the potential modulatory role of trustworthiness in the GCE. To provide a comprehensive understanding of whether trustworthiness modulates the GCE, we employed face stimuli incorporating trustworthiness information within Posner' s cue-target task. The findings of Experiment 1 revealed that the perception of trustworthiness indeed influenced the GCE. Specifically, when facial stimuli were perceived as trustworthy, they elicited a more pronounced GCE compared to untrustworthy stimuli. This modulation effect was replicated using a different stimulus set in Experiment 2. In Experiment 3, we employed the same stimuli as in Experiment 2, setting the trustworthiness information to baseline as a control experiment. The results demonstrated that the trustworthiness modulation effect disappeared, indicating its specificity to the trustworthiness attribute of the stimuli rather than other characteristics. Collectively, these findings lend support to the flexible hypothesis, highlighting that the extraction of trustworthiness information plays a pivotal role in modulating the GCE, consequently influencing social interactions.

A nurse-led structured education program improves self-management skills and reduces hospital readmissions in patients with chronic heart failure: a randomized and controlled trial in China.

INTRODUCTION: Patient self-management skills are an important part of heart failure (HF) management. However, there is a lack of knowledge about the effectiveness of nurse-led education on patient self-management and the associated clinical outcomes of rural Chinese patients with chronic heart failure (CHF). As such, this study was designed to evaluate the impact of a nurse-led education program on patient self-management and hospital readmissions in rural Chinese patients with CHF. METHODS: Ninety-six patients in the eastern Chinese province of Shandong with CHF were randomly divided into intervention and control groups. A structured education program was delivered to the intervention group during hospitalization and after discharge. Control group patients were managed as per clinical guidelines without structured education. Medication adherence, dietary modifications, social support, and symptom control were assessed 12 months after the educational intervention. RESULTS: The mean score of medication adherence, dietary modifications, social support and symptom control in the intervention group was higher than in the control group at the end of the study (p<0.01). The readmission rates for HF in the intervention and control group were 10.4% and 27.1%, respectively (p=0.036). CONCLUSIONS: This study has demonstrated that a structured education program was associated with a significant improvement in medication adherence, dietary modifications, social support, and symptom control in rural CHF patients. Furthermore, this program was associated with a significant reduction in hospital readmission. This study indicates that implementation of a nurse-led education program improves self-management and clinical outcomes of rural CHF patients, who may not have regular access to cardiac management services as per metropolitan populations.

Coalbed methane reservoir properties assessment and 3D static modeling for sweet-spot prediction in Dahebian block, Liupanshui Coal field, Guizhou Province, southwestern China.

Guizhou Province has many multi-layer, thin-thick coal seams; however, complex geology, incomplete reservoir characterization, and sweet-spot selection technology prevent large-scale coalbed methane (CBM) development. This study evaluates the CBM reservoir properties within the Dahebian block using logging data, coal sample analysis, and well-testing data and develops a 3D static reservoir properties model to analyze their spatial and vertical propagation. A sweet spot evaluation model was established using a multi-level fuzzy method based on 9 parameters extracted from a 3D static reservoir properties model. The coal measure has 22 coal seams, and seams >2 m thick have 2 or 3 thin non-coal layers intercalated. Coal seams 1#, 7#, and 11# are thin to thick, deeply buried, widely distributed, and have high gas content and saturation. Undeformed and cataclastic coal predominates the coal seam 1# and 7#, whereas coal seam 11# is dominated by cataclastic and granulated coal. The southern and central parts of coal seam 7# and 11# have less tectonically deformed coal (TDC). Coal seams 1# and 7# have low permeability relative to seam 11# and are localized, while coal seams 11# have high permeability, are extensively distributed, and contain substantial gas concentrations. Comparative analysis of evaluation scores and CBM production statistics shows that high scores indicate sweet spots for CBM development. Sweet-spot potential was classified as high, medium, and low. Scattered sweet spots are found in single layers, while combined development (1# + 7#+11#) reveals a wider high-potential area in the south-central region. This area, featuring deep, thick coal seams, high permeability, gas saturation, reservoir pressure, and low TDC proportion, indicates significant development potential. This study validates CBM development statistics, identifies future development areas, and guides the development of geologically complex Guizhou CBM.

Investigation on the influence of the macropores in coal on CBM recovery.

As an important component of coal structure, the macropores have a great influence on CBM recovery. In this paper, the macropores characteristic of two coal samples collected from 3# coal seam in the south of Qinshui Basin, China was analyzed on the basic of mercury intrusion porosimetry, and a fully coupled triple-porosity/double permeability mathematical model for CBM recovery was established according to the physical structure of coal and the non-Darcy flow of methane in macropores. Then, the various factors affecting the macropores permeability were discussed and the influence of size distribution and connectivity of macropores on CBM recovery was investigated. The following conclusions have been drawn from these efforts: (1) in 3# coal seam of the south of Qinshui Basin, the macropores have an extremely heterogeneous pore size distribution with the high variation, and their connectivity is not good because they are mainly composed of the conical and cylindrical pores with one dead end and the open pores, the structure characteristics of macropores are not conducive to CBM recovery; (2) the fully coupled triple-porosity/double permeability mathematical model containing the non-Darcy flow of methane in the macropores includes the methane occurrence-migration field, hydraulic field, thermal field and stress field as well as the complex intercoupling between them, and the model was verified by the fitting of methane production history, with an average error of 3.24%; (3) the macropores permeability is closely related to the Knudsen number controlled by methane pressure and temperature in macropores and the intrinsic permeability which is an internal attribute of macropores affected by size distribution and connectivity of pore; (4) the pressure drop of reservoir plays a major role in the macropores permeability, which promotes the increase of macropores permeability with time, and the high intrinsic permeability of macropores corresponding to the good pore size distribution and connectivity is more conducive to the improvement of fracture permeability and methane production rate of coal reservoir during CBM recovery. It is recommended that coal seams including the macropores with uniform size distribution and good connectivity should be preferentially used for the development of CBM.

Relationship between the Geological Origins of Pore-Fracture and Methane Adsorption Behaviors in High-Rank Coal.

Coal is characterized by a complex pore-fracture network and functional groups, which are derived from various geological origins and which further affect methane adsorption. To explore the relationship between the geological origins of pore-fractures and methane adsorption behaviors, we conducted pore structure tests and adsorption isotherms on six Qinshui high-rank coals. The pores and fractures were observed using an optical microscope (OM), a field emission scanning electron microscope (FESEM), and a high-resolution transmission electron microscope (HRTEM), and the pore structure parameters were determined using mercury intrusion and low-pressure N2 and CO2 adsorption. High-pressure CH4 adsorption isotherms were obtained at 30 °C using the manometric method. Results show that the Qinshui high-rank coals develop five stages of pore size distribution, consisting of the smaller micropore stage (0.3-1 nm), the larger micropore and smaller mesopore stage (1-10 nm), the mesopore and smaller macropore stage (10-110 nm), the microfracture stage (0.11-40 µm), and the larger macropore stage (>40 µm). The micropores dominate the total pore volume (PV) and specific surface area (SSA). Pores and fractures of various morphologies and sizes have different geological origins, which are related to coalification and stress field evolution. Methane adsorption on coals mainly occurs in the micropores as a form of volume filling. The maximum pore size for complete gas filling (MPSCGF) ranges from 0.60 to 0.88 nm in Qinshui high-rank coals. The coal-forming geological processes, such as coalification and stress field evolution, contribute to various pores and fractures, which show different pore sizes and functional groups. The geological origins of pores and fractures control the methane adsorption behaviors in coals by way of the pore size and functional groups. Surface coverage-related methane adsorption behavior occurs in fractures, primary pores, and large-scale secondary pores, while micropore filling is the methane adsorption behavior in macromolecular pores and small-scale secondary pores. The aim of this study is to provide a new insight into the methane adsorption on coals from the geological process of the formation and modification of pores and fractures.

Permeability Response Characteristics of Primary Undeformed Coal and Tectonically Deformed Coal under Loading-Unloading Conditions in Huainan Coalfield, China.

Reservoir pressure relief is a practical method to enhance permeability for coalbed methane (CBM) extraction in tectonically deformed coal (TDC) reservoirs. To explore the coal permeability response to stress changes, the primary undeformed coal (PUC) and TDC from the same coal seam were sampled for the pore-fissure structure analysis, mechanical property test, and permeability experiments under different stress loading-unloading methods in this study. The experimental results demonstrated that the coal permeability is more sensitive to the changes in confining pressure (perpendicular to airflow) than axial stress (parallel to airflow). Coal permeability decreases negatively exponentially as the confining pressure increases, and its change process with increased axial pressure can be divided into five stages in this study. The pore structures and mechanical properties of coal samples affected their permeability response to stress changes. Under the stress loading condition, the coal matrix and fractures of PUC samples were compressed simultaneously, and the permeability was regulated by the pore-fissure structures in the coal matrix. Due to the deformation and displacement of coal particles, the permeability of the TDC sample is predominantly dependent on changes in intergranular pores. At the initial stress unloading stage, the fissure recovery and expansion lead to a rapid increase in permeability, but the permeability cannot rereach the original value when the stress is fully released. Furthermore, the influencing factors of coal permeability in response to stress loading-unloading also include confining pressure conditions and coal matrix adsorption swelling. Research on the permeability response characteristics of the stress loading-unloading process can provide some clarifications for the reservoir depressurization and permeability enhancement of CBM extraction in the TDC reservoir.

[Effects of metformin on proliferation of human colon carcinoma cell line SW-480].

OBJECTIVE: To observe the effect of metformin on the proliferation of SW-480 cells and study the possible mechanism. METHODS: The proliferation of SW-480 cells treated with different concentrations of metformin was assessed by MTT assay, and the cell cycle changes were analyzed by flow cytometry. The expression of cyclin D1 in the treated cells was detected by Western blotting, and telomerase activity examined by telomeric repeat amplification protocol (TRAP) silver staining. RESULTS: Metformin decreased the proliferation of SW-480 cells in a dose- and time-dependent manner. The proportion of the cells at G0/G1 stage in the control and metformin-treated (5 mmol/L, 72 h) cells was (55.81-/+0.63)% and (63.38-/+0.99)%, the cell proportion at S stage was (31.11-/+3.05)% and (25.29-/+1.64)%, and that at G2/M stage was (13.09-/+3.00)% and (11.33-/+2.60)%, respectively. The expression of cyclin D1 in metformin-treated cells were lowered significantly as compared with that in the control cells. Telomerase activity was also decreased significantly in the cells after treatment with 5 mmol/L metformin for 72 h. CONCLUSION: Metformin can inhibit the growth of SW-480 cells mainly by blocking the cell cycle at G0/G1, down-regulating the expression of cyclin D1 and decreasing telomerase activity.