Detalhe da pesquisa
1.
Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy.
Proc Natl Acad Sci U S A
; 119(15): e2201632119, 2022 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35380903
2.
Targeting Mycobacterium tuberculosis response to environmental cues for the development of effective antitubercular drugs.
PLoS Biol
; 19(7): e3001355, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34319985
3.
Potency boost of a Mycobacterium tuberculosis dihydrofolate reductase inhibitor by multienzyme F420H2-dependent reduction.
Proc Natl Acad Sci U S A
; 118(25)2021 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34161270
4.
Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection.
Antimicrob Agents Chemother
; 67(2): e0145922, 2023 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36688684
5.
Lung microenvironments harbor Mycobacterium tuberculosis phenotypes with distinct treatment responses.
Antimicrob Agents Chemother
; 67(9): e0028423, 2023 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37565762
6.
Drug distribution and efficacy of the DprE1 inhibitor BTZ-043 in the C3HeB/FeJ mouse tuberculosis model.
Antimicrob Agents Chemother
; 67(11): e0059723, 2023 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37791784
7.
Strongly Bactericidal All-Oral ß-Lactam Combinations for the Treatment of Mycobacterium abscessus Lung Disease.
Antimicrob Agents Chemother
; 66(9): e0079022, 2022 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36047786
8.
Mycobacterium tuberculosis DprE1 Inhibitor OPC-167832 Is Active against Mycobacterium abscessus In Vitro.
Antimicrob Agents Chemother
; 66(12): e0123722, 2022 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36350151
9.
Cyclohexyl-griselimycin Is Active against Mycobacterium abscessus in Mice.
Antimicrob Agents Chemother
; 66(1): e0140021, 2022 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34723632
10.
Activity of Tricyclic Pyrrolopyrimidine Gyrase B Inhibitor against Mycobacterium abscessus.
Antimicrob Agents Chemother
; 66(9): e0066922, 2022 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36005813
11.
Novel Regimens of Bedaquiline-Pyrazinamide Combined with Moxifloxacin, Rifabutin, Delamanid and/or OPC-167832 in Murine Tuberculosis Models.
Antimicrob Agents Chemother
; 66(4): e0239821, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35315690
12.
A Rabbit Model to Study Antibiotic Penetration at the Site of Infection for Nontuberculous Mycobacterial Lung Disease: Macrolide Case Study.
Antimicrob Agents Chemother
; 66(3): e0221221, 2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35099272
13.
Spatial quantitation of antibiotics in bone tissue compartments by laser-capture microdissection coupled with UHPLC-tandem mass spectrometry.
Anal Bioanal Chem
; 414(23): 6919-6927, 2022 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-35945288
14.
Superior Efficacy of a Bedaquiline, Delamanid, and Linezolid Combination Regimen in a Mouse Tuberculosis Model.
J Infect Dis
; 224(6): 1039-1047, 2021 09 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33502537
15.
Blocking Bacterial Naphthohydroquinone Oxidation and ADP-Ribosylation Improves Activity of Rifamycins against Mycobacterium abscessus.
Antimicrob Agents Chemother
; 65(9): e0097821, 2021 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34228543
16.
Piperidine-4-Carboxamides Target DNA Gyrase in Mycobacterium abscessus.
Antimicrob Agents Chemother
; 65(8): e0067621, 2021 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34001512
17.
A Mycobacterium tuberculosis NBTI DNA Gyrase Inhibitor Is Active against Mycobacterium abscessus.
Antimicrob Agents Chemother
; 65(12): e0151421, 2021 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34606340
18.
Lesion Penetration and Activity Limit the Utility of Second-Line Injectable Agents in Pulmonary Tuberculosis.
Antimicrob Agents Chemother
; 65(10): e0050621, 2021 09 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34252307
19.
Pharmacokinetics and Target Attainment of SQ109 in Plasma and Human-Like Tuberculosis Lesions in Rabbits.
Antimicrob Agents Chemother
; 65(9): e0002421, 2021 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34228540
20.
Adjunctive Host-Directed Therapy With Statins Improves Tuberculosis-Related Outcomes in Mice.
J Infect Dis
; 221(7): 1079-1087, 2020 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31605489