1.
Angew Chem Int Ed Engl
; 54(25): 7381-5, 2015 Jun 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25950511
RESUMO
A chiral secondary amine phosphoramide was developed and identified as a powerful catalyst for the Mukaiyama-Michael addition of fluorinated enol silyl ethers to tetrasubstituted olefins. The resulting products are obtained with high enantioselectivities and contain a quaternary carbon stereocenter bearing either a difluoroalkyl or monofluoroalkyl group.