Detalhe da pesquisa
1.
Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.
Nature
; 629(8011): 443-449, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38658754
2.
S1P1 Modulator-Induced G αi Signaling and ß-Arrestin Recruitment Are Both Necessary to Induce Rapid and Efficient Reduction of Blood Lymphocyte Count In Vivo.
Mol Pharmacol
; 93(2): 109-118, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29203519
3.
The metabolism and drug-drug interaction potential of the selective prostacyclin receptor agonist selexipag.
Xenobiotica
; 48(7): 704-719, 2018 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28737453
4.
The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468.
J Pharmacol Exp Ther
; 362(3): 489-503, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28663311
5.
Milestones to the Discovery of T-type Calcium Channel Blockers for the Treatment of Generalized Epilepsies.
Chimia (Aarau)
; 71(10): 722-729, 2017 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29070417
6.
Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.
PLoS Med
; 13(10): e1002138, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27701420
7.
First-in-humans study of the safety, tolerability, and pharmacokinetics of ACT-451840, a new chemical entity with antimalarial activity.
Antimicrob Agents Chemother
; 59(2): 935-42, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25421475
8.
Macitentan does not interfere with hepatic bile salt transport.
J Pharmacol Exp Ther
; 350(1): 130-43, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24769543
9.
Discovery of the Clinical Candidate IDOR-1117-2520: A Potent and Selective Antagonist of CCR6 for Autoimmune Diseases.
J Med Chem
; 67(10): 8077-8098, 2024 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38727100
10.
Novel in vivo active anti-malarials based on a hydroxy-ethyl-amine scaffold.
Bioorg Med Chem Lett
; 23(3): 658-62, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23260352
11.
Letter to the Editor, Physiologically based pharmacokinetic predictions of intestinal BCRP-mediated effect of telmisartan on the pharmacokinetics of rosuvastatin in humans.
Biopharm Drug Dispos
; 38(7): 443-444, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28656708
12.
Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C.
Cancer Discov
; 12(6): 1500-1517, 2022 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35404998
13.
Induction of drug metabolizing enzymes: a survey of in vitro methodologies and interpretations used in the pharmaceutical industry--do they comply with FDA recommendations?
Chem Biol Interact
; 168(1): 51-65, 2007 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-17239835
14.
Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies.
J Med Chem
; 60(23): 9769-9789, 2017 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29116786
15.
An in vivo and in vitro comparison of CYP gene induction in mice using liver slices and quantitative RT-PCR.
Toxicol In Vitro
; 20(1): 125-31, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16098711
16.
Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction.
Expert Opin Drug Metab Toxicol
; 2(6): 875-94, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17125407
17.
Assessment of drug metabolism enzyme and transporter pharmacogenetics in drug discovery and early development: perspectives of the I-PWG.
Pharmacogenomics
; 17(6): 615-31, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-27045656
18.
Physiologically-Based Pharmacokinetic Modeling of Macitentan: Prediction of Drug-Drug Interactions.
Clin Pharmacokinet
; 55(3): 369-80, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26385839
19.
Novel S1P1 receptor agonists - Part 5: From amino-to alkoxy-pyridines.
Eur J Med Chem
; 115: 326-41, 2016 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27027817
20.
Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groups.
Eur J Med Chem
; 116: 222-238, 2016 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-27061986