Detalhe da pesquisa
1.
A Degron Blocking Strategy Towards Improved CRL4CRBN Recruiting PROTAC Selectivity.
Chembiochem
; 24(23): e202300351, 2023 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37418539
2.
Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release.
Biochem J
; 476(18): 2521-2543, 2019 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31409651
3.
Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition.
Bioorg Med Chem
; 26(11): 3021-3029, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29764757
4.
An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56.
Angew Chem Int Ed Engl
; 56(13): 3536-3540, 2017 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28225177
5.
Synthesis of a Ribose-Incorporating Medium Ring Scaffold via a Challenging Ring-Closing Metathesis Reaction.
European J Org Chem
; 2016(26): 4496-4507, 2016 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28042283
6.
Erratum: iTAG an optimized IMiD-induced degron for targeted protein degradation in human and murine cells.
iScience
; 27(5): 109727, 2024 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38646177
7.
Scaffold-focused virtual screening: prospective application to the discovery of TTK inhibitors.
J Chem Inf Model
; 53(5): 1100-12, 2013 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-23672464
8.
Synthesis and evaluation of heteroaryl substituted diazaspirocycles as scaffolds to probe the ATP-binding site of protein kinases.
Bioorg Med Chem
; 21(18): 5707-24, 2013 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23920481
9.
Determination of Ligand-Binding Affinity (Kd) Using Transverse Relaxation Rate (R2) in the Ligand-Observed 1H NMR Experiment and Applications to Fragment-Based Drug Discovery.
J Med Chem
; 66(15): 10617-10627, 2023 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37467168
10.
iTAG an optimized IMiD-induced degron for targeted protein degradation in human and murine cells.
iScience
; 26(7): 107059, 2023 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37360684
11.
Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones.
J Med Chem
; 66(8): 5892-5906, 2023 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37026591
12.
Benzimidazole inhibitors of the protein kinase CHK2: clarification of the binding mode by flexible side chain docking and protein-ligand crystallography.
Bioorg Med Chem
; 20(22): 6630-9, 2012 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23058106
13.
Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays.
Sci Rep
; 12(1): 18633, 2022 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36329085
14.
Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors.
J Med Chem
; 65(12): 8169-8190, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35657291
15.
Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo.
J Med Chem
; 65(12): 8191-8207, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35653645
16.
Analysis of water patterns in protein kinase binding sites.
Proteins
; 79(7): 2109-21, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21557316
17.
Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket.
J Med Chem
; 64(23): 17079-17097, 2021 12 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34846884
18.
Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders.
J Med Chem
; 63(8): 4047-4068, 2020 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32275432
19.
Structure-based design of molecular cancer therapeutics.
Trends Biotechnol
; 27(5): 315-28, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19339067
20.
High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers.
Mol Cancer Ther
; 18(10): 1696-1707, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31575759