RESUMO
TNF signaling does not result in cell death unless multiple inhibitory signals are overcome, which can be accomplished by simultaneous signaling through IFNγ. In this issue, Deng and colleagues (http://doi.org/10.1083/jcb.202305026) dissect the mechanisms by which IFNγ signaling combines with TNF to mediate cell death through caspase-8, discussed by James E. Vince.
Assuntos
Morte Celular , Interferon gama , Transdução de Sinais , Interferon gama/fisiologia , Caspase 8/fisiologia , Fatores de Necrose Tumoral/fisiologiaRESUMO
Los implantes mamarios de silicona se han asociado con una variedad de condiciones médicas que aparecen en coincidencia con su implantación; ello constituye la emergencia de una nueva y poco conocida patología de la modernidad. Más del 87% de los enfermos sintomáticos, presentan neuropatía desmielinizante y axonal, comprobada en la biopsia de nervio y músculo, mientras que aproximadamente el 22%-25% tienen evidencia de enfermedad tiroidea autoinmune. Un pequeño porcentaje del 10%-12%, presentan enfermedad desmielinizante primaria del sistema nervioso: esclerosis múltiple diagnósticada mediante resonancia magnética y estudios de líquido cefalorraquideo. Otros presentan condiciones inmunológicas diversas como síndrome de fibromialgia, tiroiditis de Hashimoto, polimiositis, dermatomiositis, lupus eritematoso sistémico, artritis reumatoide, esclerodermia y presencia de autoanticuerpos. Para estos pacientes sintomáticos se propone como diagnóstico unitario un síndrome adyuvante por implante de prótesis mamarias de silicon. Se presentan los casos de dos pacientes ilustrativos.
Silicone breast prosthesis has been associated with a variety of medical conditions or autoimmune diseases, which has coincidental relation with the implants insertion; it's loomed as a new and unknown pathology of the modern times. More than 87% of symptomatic patients developed demyelination axonal neuropathy demonstrated by nerve and muscle biopsy; 22% to 25% have evidence of autoimmune thyroid disease. An a small group of patients (10%-12%) have primary central nervous system demyelination disease as. multiple selerosis. The diagnosis of multiple selerosis was corroborated by magnetic resonance imaging and cerebrospinal fluid analysis. Also, an other wide spectrum of immunological diseases have been observed, such as fibromyalgia. Hashimoto's, polymyositis, dermatomyositis, lupus erythematosus, rheumatoid arthritis, scleroderma, and the presence of autoantibodies. Finally, for symptomatic patients, an adjuvant syndrome of silicone breast prosthesis or implant is proposed as a unitary diagnosis. The authors presented two patients whom illustrated this entity.