Assuntos
Doenças Mamárias/cirurgia , Mama/cirurgia , Adenoma/cirurgia , Mama/anatomia & histologia , Doenças Mamárias/classificação , Doenças Mamárias/patologia , Neoplasias da Mama/classificação , Exsudatos e Transudatos , Feminino , Fístula/cirurgia , Humanos , Infecções/classificação , Mamilos/anatomia & histologia , Mamilos/cirurgia , Doença de Paget Mamária/etiologia , Doença de Paget Mamária/patologia , Papiloma/cirurgia , Papiloma Intraductal/etiologia , Papiloma Intraductal/patologia , Papiloma Intraductal/cirurgiaRESUMO
This report describes two cases, each showing fibroepithelial proliferation, admixed with intraduct papillomas. Case 1 was from a 13-year-old female who presented with a breast mass, while case 2 was from a 60-year-old female who also had a breast lump. Case 1 showed proliferative breast disease with multiple small papillomas, some with leaf-like contours. Broad-based parenchymal proliferations protruding into ducts were also seen, and there were overlap features between the two ends of this spectrum. Case 2, similarly, demonstrated a mixed intraductal proliferation, with papillomas on narrow stalks together with low-grade phyllode areas extending into ducts from a wider base. That fibroadenoma and intraduct papilloma may have a common pathogenesis is discussed.
Assuntos
Neoplasias da Mama/patologia , Fibroadenoma/patologia , Papiloma Intraductal/patologia , Adolescente , Neoplasias da Mama/etiologia , Feminino , Fibroadenoma/etiologia , Humanos , Antígeno Ki-67/análise , Pessoa de Meia-Idade , Papiloma Intraductal/etiologiaRESUMO
We report a case of an axillary lymph node containing benign glandular lesions, intraductal papilloma with florid and atypical duct hyperplasia, and ductal carcinoma in situ. We propose 2 theories for the development of the intraductal papilloma: from adjacent benign glandular inclusions, or from displaced epithelial cells from a previous intraductal papilloma in the ipsilateral breast. This case identifies yet another etiology for false-positive sentinel lymph nodes morphologically and by immunohistochemistry.
Assuntos
Neoplasias da Mama/etiologia , Carcinoma Intraductal não Infiltrante/etiologia , Papiloma Intraductal/etiologia , Axila/patologia , Biópsia , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/patologia , Carcinoma Intraductal não Infiltrante/diagnóstico , Carcinoma Intraductal não Infiltrante/patologia , Células Epiteliais/patologia , Feminino , Humanos , Linfonodos/patologia , Pessoa de Meia-Idade , Papiloma Intraductal/diagnóstico , Papiloma Intraductal/patologiaRESUMO
The objective of this study was to clarify the patterns of recurrence and prognosis after resection of intraductal papillary mucinous tumors (IPMTs). Fourteen patients with IPMT were reviewed histologically; intraductal papillary adenocarcinoma was present in 12 cases and intraductal papillary adenoma in 2. Six patients were alive with no evidence of disease. Two patients died from other causes. Six patients had recurrences. The median survival time was 46 months. In the six recurrent cases, the median postoperative disease-free interval was 38 months. Four patients died of recurrence, and the median survival time after recurrence was 6 months. The major site of recurrence was the remnant pancreas. The other sites were the liver in two cases, peritoneum in two, and local in one. These results suggest the multicentric or metachronous oncogenesis of IPMT. Because of the low frequency of lymph node metastases, an operation to preserve pancreatic function may be recommended, especially for localized tumors such as the branch type. It is important to avoid an incomplete resection using intraoperative pancreatoscopy and ultrasonography. Long-term follow-up after surgery is necessary even for a curative resection. We should perform total pancreatectomy for recurrences without distant metastases.