Evolución de mortalidad, abandono, traslado y retención a corto, mediano y largo plazo en pacientes con infección por VIH: Fundación Arriarán 1990-2015 / Evolution of mortality, retention and loss to follow up of HIV infected subjects followed in a special clinic
Rev. méd. Chile
; 146(3): 290-299, mar. 2018. tab, graf
Article
em Es
| LILACS
| ID: biblio-961393
Biblioteca responsável:
CL1.1
ABSTRACT
Background:
The HIV epidemic reached Chile in late 1980s and as an early response, AIDS care centers were organized. Fundación Arriarán (FA) was the first center. Free antiretroviral therapy (ART) was later provided with progressive coverage and complexity over the years.Aim:
To quantify evolution of mortality, retention and loss to follow up (LTFU) over 25 years according to different periods of access to ART, from no availability to full coverage with current drugs at FA center. Material andMethods:
Retrospective analysis of FA database of 5,080 adults admitted between 1990 and 2014. The sample was distributed in 7 groups A no ART (1990-92), B monotherapy, C dual therapy, D dual/triple ART, E early triple therapy with incomplete coverage, F same as E but with complete coverage and G contemporary ART (2008-14). Mortality, retention and LTFU were evaluated at 1, 3, 5, 7 and 10 years and at 31/12/2015.Results:
Mortality varied from 40% to 2%, and 62% to 7% at 1 and 5 years, for groups A and G respectively; from 71% to 16% at 10 years for groups A and E, respectively. Retention at 5 years were 28%, 23%, 39%, 62%, 75%, 75% and 77% for groups A to G, respectively. LTFU was 10%, 19%, 15%, 17%, 9% 12% and 10% at 5 years for same groups, respectively. At 12/31/2015 22% of patients had died, 11% were LTFU, 60% were retained in care and 6% had been transferred.Conclusions:
There is a marked reduction in mortality and increase in retention of HIV patients' concomitant to expanded access to modern therapy, although LTFU remains a problem.Palavras-chave
Texto completo:
1
Base de dados:
LILACS
Assunto principal:
Infecções por HIV
/
Recusa em Tratar
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Antirretrovirais
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Programas Nacionais de Saúde
País/Região como assunto:
America do sul
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Chile
Idioma:
Es
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Chile