Termoestabilidade da vacina contra a raiva, tipo Fuenzalida & Palacios, uso humano / Thermostability of rabies vaccine, type Fuenzalida & Palacios, for human use
Rev. Inst. Med. Trop. Säo Paulo
; Rev. Inst. Med. Trop. Säo Paulo;34(1): 27-31, Jan.-Feb. 1992.
Article
em Pt
| LILACS
| ID: lil-320634
Biblioteca responsável:
BR1.1
RESUMO
Ten lots of Fuenzalida & Palacios type antirabies vaccine for human use, produced at the Instituto Butantan (São Paulo, Brazil) were stored at temperatures of 45, 37, 28 and 2-8 degrees C. The potency of each lot was determined in samples taken at varied time intervals using the NIH method and lots presenting antigenic values > or = 0,3 were considered satisfactory for use. After 2 hours at 45 degrees C the antigenic value of one out of 10 lots tested was found to be less than the minimum required value. At 37 degrees C all lots maintained satisfactory antigenic values until the third day of storage, whilst at 28 and 2-8 degrees C the potency was fully maintained, respectively for 10 and 360 days. At the ideal temperature of 2-8 degrees C, 100 of the tested vaccines maintained the minimum required antigenicity for a longer period (16 months) than the expiration time of 6-12 months usually recommended for this type of biological produced in Latin American and Caribbean countries. Thus, the obtained data suggested that in countries still producing Fuenzalida & Palacios type vaccine, the expiration tim could be extended to 16 months, what could prevent the unnecessary discarding of products still in useful condition.
Texto completo:
1
Base de dados:
LILACS
Assunto principal:
Vacina Antirrábica
Idioma:
Pt
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Brasil