Vitamin D deficiency is independently associated with mortality among critically ill patients
Clinics
; 70(5): 326-332, 05/2015. tab, graf
Article
em En
| LILACS
| ID: lil-748274
Biblioteca responsável:
BR1.1
ABSTRACT
OBJECTIVE:
Studies suggest an association between vitamin D deficiency and morbidity/mortality in critically ill patients. Several issues remain unexplained, including which vitamin D levels are related to morbidity and mortality and the relevance of vitamin D kinetics to clinical outcomes. We conducted this study to address the association of baseline vitamin D levels and vitamin D kinetics with morbidity and mortality in critically ill patients.METHOD:
In 135 intensive care unit (ICU) patients, vitamin D was prospectively measured on admission and weekly until discharge from the ICU. The following outcomes of interest were analyzed 28-day mortality, mechanical ventilation, length of stay, infection rate, and culture positivity.RESULTS:
Mortality rates were higher among patients with vitamin D levels <12 ng/mL (versus vitamin D levels >12 ng/mL) (32.2% vs. 13.2%), with an adjusted relative risk of 2.2 (95% CI 1.07-4.54; p< 0.05). There were no differences in the length of stay, ventilation requirements, infection rate, or culture positivity.CONCLUSIONS:
This study suggests that low vitamin D levels on ICU admission are an independent risk factor for mortality in critically ill patients. Low vitamin D levels at ICU admission may have a causal relationship with mortality and may serve as an indicator for vitamin D replacement among critically ill patients. .Palavras-chave
Texto completo:
1
Base de dados:
LILACS
Assunto principal:
Exposição Ocupacional
/
Bombeiros
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Síndrome Metabólica
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Poluentes Ocupacionais do Ar
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Poeira
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Pneumopatias Obstrutivas
País/Região como assunto:
America do norte
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Brasil