CD4 T cells remain the major source of HIV-1 during end stage disease.
AIDS
; 13(9): 1015-9, 1999 Jun 18.
Article
em En
| MEDLINE
| ID: mdl-10397529
ABSTRACT
OBJECTIVE:
To assess the source of HIV-1 production in lymphoid tissue biopsies from HIV-infected patients, with no prior anti-retroviral protease inhibitor treatment, with a CD4 cell count > 150 x 10(6)/l (group I) or < 50 x 10(6)/l (group II), co-infected with Mycobacterium tuberculosis or Mycobacterium avium complex. DESIGN ANDMETHODS:
Lymphoid tissue biopsies from 11 HIV-1-infected patients, taken for diagnostic purposes, were studied by HIV-1 RNA in situ hybridization and immunohistochemistry.RESULTS:
Patients of group I showed well organized granulomas, in contrast with patients of group II, in which granuloma formation was absent. HIV-1 RNA-positive cells in group I patients were found mainly around the granulomas, whereas in group II HIV-1-producing cells were confined to areas with remaining intact lymphoid tissue. Despite the abundant presence of macrophages, the productively infected HIV-1-positive cells in both groups were almost exclusively CD4 T cells.CONCLUSION:
In contrast with previously published data, CD4 T cells appear to remain the major source of HIV-1 production in end-stage disease.
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Base de dados:
MEDLINE
Assunto principal:
Tuberculose
/
Linfócitos T CD4-Positivos
/
Infecção por Mycobacterium avium-intracellulare
/
HIV-1
/
Infecções Oportunistas Relacionadas com a AIDS
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Holanda