Intracranial hemorrhage rates and effect of immediate beta-blocker use in patients with acute myocardial infarction treated with tissue plasminogen activator. Participants in the National Registry of Myocardial Infarction-2.
Am J Cardiol
; 85(3): 294-8, 2000 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-11078295
ABSTRACT
In acute myocardial infarction (AMI), immediate beta-blocker therapy reduces the incidence of reinfarction and recurrent chest pain in patients receiving tissue plasminogen activator (t-PA). Data from the Thrombolysis in Myocardial Infarction (TIMI)-2 trial also raises the possibility that such therapy may reduce the rate of intracranial hemorrhage (ICH). We reviewed data obtained from 60,329 patients treated with t-PA who were enrolled in the National Registry of Myocardial Infarction 2. Of the 60,329 in the study cohort, 23,749 patients (39.4%) were treated with immediate beta-blocker therapy and 542 patients (0.9%) developed an ICH. In a multivariate model that included all covariates known to be associated with the development of ICH, immediate beta-blocker therapy was associated with a 31% reduction in the ICH rate (odds ratio 0.69, 95% confidence intervals 0.57 to 0.84). Thus, in the present study, the use of immediate beta-blocker therapy in patients with AMI treated with t-PA was associated with a significant reduction in ICH. This finding supports the observations made in the TIMI 2 trial and serves to reinforce the recommendations made by the American College of Cardiology/American Heart Association task force that immediate beta-blocker therapy should be administered to all patients with AMI who do not have contraindications to this therapy.
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Base de dados:
MEDLINE
Assunto principal:
Ativadores de Plasminogênio
/
Terapia Trombolítica
/
Ativador de Plasminogênio Tecidual
/
Antagonistas Adrenérgicos beta
/
Hemorragias Intracranianas
/
Infarto do Miocárdio
País/Região como assunto:
America do norte
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos