A ribonucleotide reductase homolog of cytomegalovirus and endothelial cell tropism.
Science
; 291(5502): 303-5, 2001 Jan 12.
Article
em En
| MEDLINE
| ID: mdl-11209080
ABSTRACT
Human cytomegalovirus infects vascular tissues and has been associated with atherogenesis and coronary restenosis. Although established laboratory strains of human cytomegalovirus have lost the ability to grow on vascular endothelial cells, laboratory strains of murine cytomegalovirus retain this ability. With the use of a forward-genetic procedure involving random transposon mutagenesis and rapid phenotypic screening, we identified a murine cytomegalovirus gene governing endothelial cell tropism. This gene, M45, shares sequence homology to ribonucleotide reductase genes. Endothelial cells infected with M45-mutant viruses rapidly undergo apoptosis, suggesting that a viral strategy to evade destruction by cellular apoptosis is indispensable for viral growth in endothelial cells.
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Base de dados:
MEDLINE
Assunto principal:
Ribonucleotídeo Redutases
/
Proteínas Virais
/
Endotélio Vascular
/
Muromegalovirus
/
Genes Virais
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos