Expression of the Dan gene during chicken embryonic development.
Mech Dev
; 109(2): 363-5, 2001 Dec.
Article
em En
| MEDLINE
| ID: mdl-11731250
ABSTRACT
The Dan gene was first identified as the putative rat tumor suppressor gene and encodes a protein structurally related to Cerberus and Gremlin in vertebrates. Xenopus DAN, as with Cerberus and Gremlin, was demonstrated to block bone morphogenetic protein (BMP) signaling by binding BMPs, and to be capable of inducing additional anterior structures by ectopic overexpression in Xenopus embryos. DAN, thus, is suggested to play pivotal roles in early patterning and subsequent organ development, as in the case of other BMP antagonists. In this report, we isolated the chicken counterpart of Dan. Chicken Dan is mainly expressed in the cephalic and somitic mesoderm and several placodes during organ development.
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Base de dados:
MEDLINE
Assunto principal:
Biossíntese de Proteínas
/
Proteínas
/
Proteínas de Xenopus
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Japão