Non-surgical management of spinal cord injury.
Expert Opin Investig Drugs
; 11(4): 469-82, 2002 Apr.
Article
em En
| MEDLINE
| ID: mdl-11922856
ABSTRACT
Spinal cord injury remains a devastating neurological condition with limited therapeutic opportunities. Since decompressive surgery and high-dose methylprednisolone have limited utility for most patients, spinal cord injury clearly represents a major medical challenge. Experimental evidence has suggested that secondary cellular injury processes may be a realistic target for therapeutic intervention with the goal of inhibiting the progression of detrimental changes that normally follows traumatic injury to the cord. Preventing or reducing this delayed cellular injury may alone improve neurological recovery or facilitate future regenerative approaches to the injured cord. This review summarises recent advances in the development of pharmacological agents targeting the acute phase of spinal cord injury as well as potential strategies to facilitate regeneration of the spinal cord.
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Base de dados:
MEDLINE
Assunto principal:
Traumatismos da Medula Espinal
/
Fármacos Neuroprotetores
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos