Intercalary heterochromatin in Drosophila melanogaster polytene chromosomes and the problem of genetic silencing.
Genetica
; 117(2-3): 259-70, 2003 Mar.
Article
em En
| MEDLINE
| ID: mdl-12723705
ABSTRACT
The morphological characteristics of intercalary heterochromatin (IH) are compared with those of other types of silenced chromatin in the Drosophila melanogaster genome pericentric heterochromatin (PH) and regions subject to position effect variegation (PEV). We conclude that IH regions in polytene chromosomes are binding sites of silencing complexes such as PcG complexes and of SuUR protein. Binding of these proteins results in the appearance of condensed chromatin and late replication of DNA, which in turn may result in DNA underreplication. IH and PH as well as regions subject to PEV have in common the condensed chromatin appearance, the localization of specific proteins, late replication, underreplication in polytene chromosomes, and ectopic pairing.
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Base de dados:
MEDLINE
Assunto principal:
Heterocromatina
/
Inativação Gênica
/
Drosophila melanogaster
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Federação Russa