Metal-ion induced amplification of three receptors from dynamic combinatorial libraries of peptide-hydrazones.
Org Biomol Chem
; 1(9): 1625-33, 2003 May 07.
Article
em En
| MEDLINE
| ID: mdl-12926295
ABSTRACT
Three building blocks of general structure (MeO)2 CH-aromatic linker-Pro-amino acid-NHNH2 have been prepared and tested in acid-catalysed dynamic combinatorial libraries. Exposure of these libraries to LiI and NaI led to the amplification of three macrocyclic pseudopeptide receptors. The receptors were isolated and their interactions with LiI and NaI were analysed using NMR, IR and ITC. Binding of the metal ions to the receptors is invariably entropy-driven. Nevertheless, all receptors were found to be flexible with substantial conformational rearrangements accompanying guest binding. This type of receptor is extremely difficult to access through rational design and the fact that dynamic combinatorial chemistry allows facile access to these challenging molecules underlines the power of the dynamic approach.
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Receptores de Droga
/
Sódio
/
Técnicas de Química Combinatória
/
Hidrazonas
/
Lítio
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article