Genetic dissection of autoimmune type I diabetes in the BB rat.
Nat Genet
; 2(1): 56-60, 1992 Sep.
Article
em En
| MEDLINE
| ID: mdl-1303251
ABSTRACT
The BB rat is among the best models of insulin-dependent diabetes mellitus--with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T-cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus Tipo 1
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article