Viral susceptibility of an immortalized human microvascular endothelial cell line.
J Virol Methods
; 39(1-2): 83-90, 1992 Sep.
Article
em En
| MEDLINE
| ID: mdl-1430067
ABSTRACT
CDC/EU.HMEC-1 is the first immortalized human microvascular endothelial cell line that retains morphologic, phenotypic, and functional characteristics of a normal human microvascular endothelial cell. This study evaluates a variety of viruses and their effects on this human endothelial cell line. The data indicate that adenoviruses, some herpesviruses, reoviruses and most picornaviruses grow well in HMEC-1, with distinctive cytopathic effects. The paramyxoviruses, however, do not appear to propagate, nor does HIV. The findings indicate that microvascular endothelial cells may act as a reservoir of these viruses; it also suggests the possibility that microvascular endothelium could be involved in the processing and presentation of antigen to immune cells.
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Base de dados:
MEDLINE
Assunto principal:
Vírus
/
Endotélio Vascular
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article