Novel factor Xa inhibitors based on a benzoic acid scaffold and incorporating a neutral P1 ligand.
Bioorg Med Chem Lett
; 14(11): 2801-5, 2004 Jun 07.
Article
em En
| MEDLINE
| ID: mdl-15125936
ABSTRACT
A series of novel, highly potent, achiral factor Xa inhibitors based on a benzoic acid scaffold and containing a chlorophenethyl moiety directed towards the protease S1 pocket is described. A number of structural features, such as the requirements of the P1, P4 and ester-binding pocket ligands were explored with respect to inhibition of factor Xa. Compound 46 was found to be the most potent compound in a series of antithrombotic secondary assays.
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Base de dados:
MEDLINE
Assunto principal:
Benzoatos
/
Fibrinolíticos
/
Inibidores do Fator Xa
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Alemanha