Calcium mediates bidirectional growth cone turning induced by myelin-associated glycoprotein.
Neuron
; 44(6): 909-16, 2004 Dec 16.
Article
em En
| MEDLINE
| ID: mdl-15603734
Cytoplasmic second messengers, Ca2+ and cAMP, regulate nerve growth cone turning responses induced by many guidance cues, but the causal relationship between these signaling pathways has been unclear. We here report that, for growth cone turning induced by a gradient of myelin-associated glycoprotein (MAG), cAMP acts by modulating MAG-induced Ca2+ signaling. Growth cone repulsion induced by MAG was accompanied by localized Ca2+ signals on the side of the growth cone facing the MAG source, due to Ca2+ release from intracellular stores. Elevating cAMP signaling activity or membrane depolarization enhanced MAG-induced Ca2+ signals and converted growth cone repulsion to attraction. Directly imposing high- or low-amplitude Ca2+ signals with an extracellular gradient of Ca2+ ionophore was sufficient to trigger either attractive or repulsive turning, respectively. Thus, distinct Ca2+ signaling, which can be modulated by cAMP, mediates the bidirectional turning responses induced by MAG.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cálcio
/
Glicoproteína Associada a Mielina
/
Cones de Crescimento
/
Sinalização do Cálcio
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos