The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis.
Nat Rev Cancer
; 5(10): 786-95, 2005 Oct.
Article
em En
| MEDLINE
| ID: mdl-16175178
ABSTRACT
Recent research has highlighted the fundamental role of the tumour's extracellular metabolic microenvironment in malignant invasion. This microenvironment is acidified primarily by the tumour-cell Na(+)/H(+) exchanger NHE1 and the H(+)/lactate cotransporter, which are activated in cancer cells. NHE1 also regulates formation of invadopodia - cell structures that mediate tumour cell migration and invasion. How do these alterations of the metabolic microenvironment and cell invasiveness contribute to tumour formation and progression?
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Base de dados:
MEDLINE
Assunto principal:
Trocadores de Sódio-Hidrogênio
/
Proteínas de Transporte de Cátions
/
Proteínas de Membrana
/
Metástase Neoplásica
/
Neoplasias
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Itália