Pre-treatment proliferation and the outcome of conventional and accelerated radiotherapy.
Eur J Cancer
; 42(3): 363-71, 2006 Feb.
Article
em En
| MEDLINE
| ID: mdl-16386890
ABSTRACT
This study investigated the influence of pre-treatment proliferation characteristics, assessed by Ki-67 staining, in patients treated in the CHART trial of accelerated radiotherapy in head and neck cancer. Histological material from 402 patients was collected and stained for the presence and pattern of Ki-67 staining. Locoregional control and overall survival were the main clinical endpoints. Increasing Ki-67 positivity was associated with decreasing differentiation (P < 0.001) and increasing N-stage (P < 0.004). Increasing N-stage was also associated with the progression of proliferation pattern from marginal to random (P < 0.001). Using a multivariate model, a trend was seen towards a greater benefit from CHART in the lower Ki-67 tumours (P = 0.08); this became significant by pooling the low and intermediate Ki-67 groups in comparison with the high Ki-67 group (P = 0.032). Tumours with marginal proliferation pattern showed a lower hazard ratio with CHART versus conventional for locoregional control (P = 0.005). The data presented in this study do not support that a high pre-treatment Ki-67 is associated with a therapeutic benefit from accelerated radiotherapy.
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Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Escamosas
/
Antígeno Ki-67
/
Proliferação de Células
/
Neoplasias de Cabeça e Pescoço
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Reino Unido