Virus-specific CD4+ T cells: ready for direct attack.
J Exp Med
; 203(4): 805-8, 2006 Apr 17.
Article
em En
| MEDLINE
| ID: mdl-16549599
ABSTRACT
CD4+ T cells are classically thought to orchestrate adaptive immune responses. But recent studies demonstrate that they can also kill infected cells directly. A new paper shows that highly efficient processing of Epstein Barr virus (EBV) glycoproteins for presentation on MHC class II makes virus-transformed B cells susceptible to lysis by CD4+ T cells. Thus, antiviral vaccines should aim to stimulate both helper and cytolytic CD4+ T cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T CD4-Positivos
/
Citotoxicidade Imunológica
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos