Inhibitory effects of cranberry polyphenols on formation and acidogenicity of Streptococcus mutans biofilms.
FEMS Microbiol Lett
; 257(1): 50-6, 2006 Apr.
Article
em En
| MEDLINE
| ID: mdl-16553831
ABSTRACT
Cranberry fruit is a rich source of polyphenols, and has shown biological activities against Streptococcus mutans. In the present study, we examined the influence of extracts of flavonols (FLAV), anthocyanins (A) and proanthocyanidins (PAC) from cranberry on virulence factors involved in Streptococcus mutans biofilm development and acidogenicity. PAC and FLAV, alone or in combination, inhibited the surface-adsorbed glucosyltransferases and F-ATPases activities, and the acid production by S. mutans cells. Furthermore, biofilm development and acidogenicity were significantly affected by topical applications of PAC and FLAV (P<0.05). Anthocyanins were devoid of any significant biological effects. The flavonols are comprised of mostly quercetin glycosides, and the PAC are largely A-type oligomers of epicatechin. Our data show that proanthocyanidins and flavonols are the active constituents of cranberry against S. mutans.
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Base de dados:
MEDLINE
Assunto principal:
Fenóis
/
Streptococcus mutans
/
Flavonoides
/
Biofilmes
/
Vaccinium macrocarpon
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos