Alpha-heteroarylation of esters, lactones, amides, and lactams by nucleophilic aromatic substitution.
Org Lett
; 8(7): 1447-50, 2006 Mar 30.
Article
em En
| MEDLINE
| ID: mdl-16562913
ABSTRACT
[reaction see text] A mild and efficient alpha-heteroarylation of simple esters and amides was developed via nucleophilic aromatic substitution. The choice of NaHMDS in toluene gave the best results. A tandem alpha-heteroarylation and hydroxylation protocol using air as the oxidant afforded tertiary alcohols in good yields.
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Base de dados:
MEDLINE
Assunto principal:
Oxidantes
/
Técnicas de Química Combinatória
/
Álcoois
/
Amidas
/
Lactamas
/
Lactonas
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos