Structure-activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416.
Bioorg Med Chem
; 14(19): 6492-501, 2006 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-16860559
ABSTRACT
A series of combretastatin A-4 analogs derived from the ATP competitive, VEGF receptor tyrosine kinase inhibitor, SU5416 were synthesized. The cytotoxic effects of the analogs were evaluated against PC-3 and MDA-MB-231 cancer cell lines, as well as their abilities to inhibit tubulin polymerization. Results are compared to those of compound 1, our lead compound previously reported.
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Base de dados:
MEDLINE
Assunto principal:
Pirróis
/
Estilbenos
/
Indóis
/
Antineoplásicos Fitogênicos
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos