Structural effects of a covalent linkage between antithrombin and heparin: covalent N-terminus attachment of heparin enhances the maintenance of antithrombin's activated state.

Mewhort-Buist, Tracy Anne; Junop, Murray; Berry, Leslie R; Chindemi, Paul; Chan, Anthony K C

Mewhort-Buist, Tracy Anne; Junop, Murray; Berry, Leslie R; Chindemi, Paul; Chan, Anthony K C.

Afiliação

Mewhort-Buist TA; Department of Pediatrics, Henderson Research Centre, 711 Concession Street, Hamilton, ON, Canada L8V 1C3.

J Biochem ; 140(2): 175-84, 2006 Aug.

Article em En | MEDLINE | ID: mdl-16954536

Assuntos

Heparina/química; Trombina/antagonistas & inibidores; Heparina/metabolismo; Ligação de Hidrogênio; Modelos Moleculares; Ligação Proteica; Conformação Proteica; Trombina/química

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