[Pharmacokinetics of hylotelephin in Beagle dogs].
Yao Xue Xue Bao
; 41(7): 680-3, 2006 Jul.
Article
em Zh
| MEDLINE
| ID: mdl-17007365
ABSTRACT
AIM:
To investigate the pharmacokinetics of hylotelephin in Beagle dogs and obtain the main pharmacokinetic parameters.METHODS:
An HPLC method with UV detection was developed to study the pharmacokinetics of hylotelephin in dogs by joining an internal standard (anthracene). Benzoyl chloride was used to the pre-column derivatization of hylotelephin and methanol-water (6436) was used as the mobile phase. According to the 3P97 pharmacokinetic program, the main parameters were calculated.RESULTS:
The hylotelephin pharmacokinetics conforms to a two-compartment open model after a single iv dose of hylotelephin 10.6 or 21.3 mg x kg(-1) in Beagle dogs. The parameters of two groups were as follows T(1/2) alpha were 2.3 and 2.1 min, T(1/2) beta were 1.9 and 2.0 h, K12 were 0. 12 and 0.11 min, K21 were 0.17 and 0.21 min, K10 were 0.011 and 0.0094 min, Vc were 0.54 and 0.54 L x kg(-1), AUC were 1.8 and 4.1 g x min x L(-1), CL were 0.0048 and 0.0056 L x kg(-1) x min(-1), MRT were 2.10 and 2.4 h, respectively.CONCLUSION:
The pharmacokinetics of hylotelephin after iv administration showed a rapid distribution and elimination process in Beagle dogs and was of first order kinetics.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Plantas Medicinais
/
Compostos Heterocíclicos com 3 Anéis
Idioma:
Zh
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
China