[Drug binding to blood proteins: characteristics, roles and pathophysiological changes]. / Liaisons des médicaments aux protéines circulantes: caractéristiques, rôles et modifications physio-pathologiques.
Bull Acad Natl Med
; 190(4-5): 935-46; discussion 946-7, 2006.
Article
em Fr
| MEDLINE
| ID: mdl-17195618
ABSTRACT
HSA and AGP are the only plasma proteins capable of binding drugs through specific sites with high affinity. As such, they can limit drug distribution and, sometimes, drug elimination. Such binding is called restrictive. Low binding capacities are said to be permissive, as they do not lead to drug retention. Modifications of restrictive binding can influence other pharmacokinetic parameters and also have clinical implications.
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Base de dados:
MEDLINE
Assunto principal:
Farmacocinética
/
Preparações Farmacêuticas
/
Proteínas Sanguíneas
Idioma:
Fr
Ano de publicação:
2006
Tipo de documento:
Article