Effects of progesterone on experimental spinal cord injury.
Brain Res
; 1137(1): 146-52, 2007 Mar 16.
Article
em En
| MEDLINE
| ID: mdl-17204255
ABSTRACT
Progesterone has been proposed to be protective to the central nervous system following injury. This study assessed progesterone supplementation in the setting of contusional spinal cord injury in male and female rats. Short-term (5 days of either 4 or 8 mg/kg progesterone) and long-term (14 days of either 8 or 16 mg/kg progesterone) therapy failed to show any significant alteration in locomotor functioning and injury morphometrics after 21 days. This study does not support progesterone as a potential therapeutic agent in spinal cord injury.
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Base de dados:
MEDLINE
Assunto principal:
Progestinas
/
Progesterona
/
Traumatismos da Medula Espinal
/
Modelos Animais de Doenças
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos