Occlusal disharmony induces spatial memory impairment and hippocampal neuron degeneration via stress in SAMP8 mice.
Neurosci Lett
; 414(2): 188-91, 2007 Mar 06.
Article
em En
| MEDLINE
| ID: mdl-17207572
ABSTRACT
We examined the effect of occlusal disharmony in senescence-accelerated (SAMP8) mice on plasma corticosterone levels, hippocampal neuron number, and spatial performance in the water maze. The bite-raised condition was associated with an accelerated age-related decline in spatial memory, increased plasma corticosterone levels, and a decreased number of neurons in the hippocampal CA3 region. The findings suggest that the bite-raised condition in aged SAMP8 mice induces hippocampal neuron loss, thereby leading to senile memory deficits.
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Base de dados:
MEDLINE
Assunto principal:
Estresse Psicológico
/
Hipocampo
/
Má Oclusão
/
Transtornos da Memória
/
Degeneração Neural
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Japão